Paul-Emmanuel Larchanché

发表

A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration

L. Buée, N. Sergeant, D. Blum, 2021, Frontiers in Pharmacology.

A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration

L. Buée, N. Sergeant, D. Blum, 2021, bioRxiv.

Buchwald reaction as the key step for the synthesis of metabolically more stable analogs of amodiaquine.

P. Melnyk, N. Le Fur, Paul-Emmanuel Larchanché, 2011, European journal of medicinal chemistry.

A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors.

L. Buée, N. Sergeant, V. Vingtdeux, 2018, European journal of medicinal chemistry.

Chloroquine and chloroquinoline derivatives as models for the design of modulators of amyloid Peptide precursor metabolism.

A. Delacourte, L. Buée, C. Sergheraert, 2015, ACS chemical neuroscience.

New phenylaniline derivatives as modulators of amyloid protein precursor metabolism.

L. Buée, N. Sergeant, S. Yous, 2018, Bioorganic & medicinal chemistry.

Methodology to Access Tetrahydrodipyridoimidazole Derivatives

P. Melnyk, P. Carato, M. Donnier-Maréchal, 2012 .

Carboline- and phenothiazine-derivated heterocycles as potent SIGMA-1 protein ligands.

P. Melnyk, P. Carato, M. Donnier-Maréchal, 2015, European journal of medicinal chemistry.

New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

L. Buée, N. Sergeant, V. Vingtdeux, 2019, Neurobiology of Disease.

Evaluation of three neutral capillary coatings for the determination of analyte-cyclodextrin binding constants by affinity capillary electrophoresis. Application to N,N'-disubstituted piperazine derivatives.

J. Goossens, C. Danel, C. Vaccher, 2016, Journal of chromatography. A.

Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles

L. Buée, N. Sergeant, P. Melnyk, 2022, International journal of molecular sciences.

Synthesis and pharmacological evaluation of benzamide derivatives as potent and selective sigma-1 protein ligands.

P. Melnyk, R. Boulahjar, P. Carato, 2017, European journal of medicinal chemistry.

A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APPSwe/PSEN1ΔE9 Mice Model of Amyloid Pathology

N. Sergeant, P. Melnyk, Jamal El Bakali, 2023, International journal of molecular sciences.

6-Sulfonylbenzothiazolones as potential scaffolds for the design of 5-HT6 ligands.

P. Melnyk, P. Dallemagne, P. Carato, 2015, European journal of medicinal chemistry.

Optimized and convergent synthesis of potent anti-malarial aminoquinoline compounds: easy access to analogs

P. Melnyk, Paul-Emmanuel Larchanché, N. Fur, 2010 .