R. Palte

发表

Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors.

Karin M. Otte, G. Morriello, B. Pio, 2021, RSC medicinal chemistry.

Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).

M. Altman, Haiyan Xu, P. Siliphaivanh, 2020, ACS medicinal chemistry letters.

Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity.

M. Altman, Christopher Sondey, J. Saurí, 2022, Bioorganic & medicinal chemistry.

Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.

Theodore A. Martinot, J. O'neil, J. Cumming, 2020, ACS medicinal chemistry letters.

Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.

Theodore A. Martinot, J. Cumming, A. Palani, 2021, ACS medicinal chemistry letters.

Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases.

M. van der Stelt, S. Nagpal, J. Maclean, 2020, ACS medicinal chemistry letters.

Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology

J. O'neil, J. Cumming, A. Palani, 2021, ACS medicinal chemistry letters.

Author Correction: Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action

J. O'neil, G. Scapin, M. Bailly, 2021, Communications Biology.

Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action

J. O'neil, G. Scapin, M. Bailly, 2021, Communications biology.

Discovery of non-Boronic acid Arginase 1 Inhibitors through Virtual Screening and Biophysical Methods.

S. So, X. Chai, D. McLaren, 2023, Bioorganic & medicinal chemistry letters.

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.

Ryan V. Quiroz, Daniel S Spellman, Haiyan Xu, 2021, Journal of medicinal chemistry.

Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.

Michael J. Ardolino, Karin M. Otte, M. Kennedy, 2021, Journal of medicinal chemistry.

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.

Theodore A. Martinot, Michael J. Ardolino, Matthew L. Maddess, 2022, Journal of medicinal chemistry.

Development of a Flexible and Robust Synthesis of Tetrahydrofuro[3,4-b]furan Nucleoside Analogues.

Ryan V. Quiroz, Hongming Li, D. Witter, 2021, The Journal of organic chemistry.

Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.

Michael J. Ardolino, Karin M. Otte, Matthew J. Fell, 2023, Journal of medicinal chemistry.