Limei Ju

发表

Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures

K. Staras, K. Caldecott, H. Hanzlíková, 2021, EMBO reports.

Poly(ADP-ribose) Polymerase-1 Hyperactivity at DNA Single-Strand Breaks Triggers Seizures and Shortened Lifespan

K. Staras, K. Caldecott, S. Rulten, 2018, bioRxiv.

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin

K. Caldecott, S. Katyal, S. El-Khamisy, 2009, DNA repair.

Highlights PARP-3 activity is stimulated by DNA double-strand breaks PARP-3 accelerates DSB repair in concert with the ADP-ribose binding protein, APLF PARP-3 and APLF render chromatin ‘permissible’ for DNA ligation by XRCC4/DNA ligase IV

B. Reina-San-Martin, G. Poirier, K. Caldecott, 2010 .

Aberrant PARP1 Activity Couples DNA Breaks to Deregulated Presynaptic Calcium Signalling and Lethal Seizures

K. Staras, K. Caldecott, S. Rulten, 2018 .

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

Y. Pommier, D. Huylebroeck, Z. Zeng, 2012, Nucleic acids research.

Requirement for DNA Ligase IV during Embryonic Neuronal Development

P. Jeggo, Zhao-Qi Wang, A. Carr, 2011, The Journal of Neuroscience.

TDP 2 promotes repair of topoisomerase I mediated DNA damage in the absence of TDP 1

Y. Pommier, D. Huylebroeck, Z. Zeng, 2019 .

TDP1 facilitates chromosomal single‐strand break repair in neurons and is neuroprotective in vivo

K. Caldecott, S. Katyal, P. Mckinnon, 2007, The EMBO journal.

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

D. Huylebroeck, Z. Zeng, K. Caldecott, 2013, PLoS genetics.

PARP-3 and APLF function together to accelerate nonhomologous end-joining.

B. Reina-San-Martin, G. Poirier, K. Caldecott, 2011, Molecular cell.

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.

H. Fuchs, D. Busch, E. Wolf, 2013, DNA repair.

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.

C. Brenner, P. Byrd, A. Taylor, 2004, DNA repair.

XRCC1 Mutation is Associated with PARP1 Hyperactivation and Cerebellar Ataxia

Keith W. Caldecott, Kevin Staras, Limei Ju, 2016, Nature.

A coordinated DNA damage response promotes adult quiescent neural stem cell activation

P. Jeggo, L. Barazzuol, Limei Ju, 2017, PLoS biology.

Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates

D. Dormann, K. Lamsa, A. Carr, 2016, Cerebral cortex.

Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells

P. Jeggo, L. Barazzuol, Limei Ju, 2015, Journal of Cell Science.

Endogenous and X-ray-induced DNA double-strand breaks sensitively activate apoptosis in adult neural stem cells

P. Jeggo, L. Barazzuol, Limei Ju, 2015 .

Distinct response of adult neural stem cells to low versus high dose ionising radiation.

P. Jeggo, L. Barazzuol, S. Hopkins, 2019, DNA repair.

PARP-3 and APLF function together to accelerate nonhomologous end-joining.

B. Reina-San-Martin, K. Caldecott, S. Rulten, 2011, Molecular cell.