R. Dougherty

发表

Cytosolic calcium regulates phorbol diester binding affinity in intact phagocytes.

J. Niedel, R. Dougherty, 1985, The Journal of biological chemistry.

3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A agonists that demonstrate oral activity as satiety agents.

M. K. James, T. Willson, B. Henke, 1996, Journal of medicinal chemistry.

Secretagogue-induced phosphoinositide metabolism in human leucocytes.

J. Putney, R. Freer, P. C. Hoyle, 1984, The Biochemical journal.

Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates.

I. Sims, W. Pendergast, J. Douglass, 2001, Bioorganic & medicinal chemistry letters.

Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells.

E. Lapetina, S. Brandt, J. Niedel, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacology of INS37217 [P1-(Uridine 5′)-P4- (2′-deoxycytidine 5′)tetraphosphate, Tetrasodium Salt], a Next-Generation P2Y2 Receptor Agonist for the Treatment of Cystic Fibrosis

R. Boucher, C. W. Davis, J. Boyer, 2002, Journal of Pharmacology and Experimental Therapeutics.

Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists.

M. K. James, T. Willson, B. Henke, 1997, Journal of medicinal chemistry.

Novel KV7 ion channel openers for the treatment of epilepsy and implications for detrusor tissue contraction.

Dwight M. Morrow, G. Higgins, Y. Matsuoka, 2018, Bioorganic & medicinal chemistry letters.

Next-Generation P 2 Y 2 Receptor Agonist for the Treatment of Cystic Fibrosis

C. W. Davis, J. Boyer, W. Abraham, 2002 .

Native and Recombinant Receptors: Role of Glycos ylation

L. Miller, E. Hadac, D. Pinon, 2006 .

Dynamics of the diradylglycerol responses of stimulated phagocytes.

J. Niedel, G. Dubay, R. Dougherty, 1989, The Journal of biological chemistry.

Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.

R. Snyderman, R. Bell, J. Niedel, 1986, Journal of immunology.

Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent.

M. K. James, T. Willson, B. Henke, 1996, Journal of medicinal chemistry.

Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity. 1. Optimization of the agonist "trigger".

M. K. James, L. Miller, R. Carr, 1996, Journal of medicinal chemistry.

Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils.

J. Niedel, L. Rider, R. Dougherty, 1988, Journal of immunology.

Detailed characterization of a purified type 4 phosphodiesterase, HSPDE4B2B: differentiation of high- and low-affinity (R)-rolipram binding.

W. Rocque, W. Holmes, G. B. Wisely, 1997, Protein expression and purification.

Reproductive toxicity and lack of dominant lethal effects of 2,4-dinitrotoluene in the male rat.

J. Borzelleca, J. Egle, G. Simon, 1985, Drug and chemical toxicology.

Dominant lethal assay of chlordecone and its distribution in the male reproductive tissues of the rat.

J. Borzelleca, J. Egle, G. Simon, 1986, Toxicology letters.

DRUG ANALYSIS BASED ON SIGNALING RESPONSES TO G-PROTEIN-COUPLED RECEPTORS

J. Boyer, R. Dougherty, T. Harden, 2001, Journal of receptor and signal transduction research.

Relationship Between Native and Recombinant Cholecystokinin Receptors: Role of Differential Glycosylation

L. Miller, D. Pinon, R. Dougherty, 1996, Pancreas.

Discovery of 1,5‐Benzodiazepines with Peripheral Cholecystokinin (CCK‐ A) Receptor Agonist Activity (II): Optimization of the C3 Amino Substituent.

T. Willson, B. Henke, J. Szewczyk, 1997 .

Structure-activity relationships involving the catechol subunit of rolipram

F. Schoenen, J. Stafford, P. Domanico, 1994 .

4-Substituted Uridine 5′-Triphosphates as Agonists of the P2Y2 Purinergic Receptor

M. K. James, S. Siddiqi, W. Pendergast, 1997 .

Modification of receptor selectivity and functional activity in cholecystokinin peptoid ligands.

M. K. James, J. Mosher, M. Grizzle, 1995, Journal of medicinal chemistry.