Gareth Williams

发表

Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS).

S. Krähenbühl, M. Walles, Nenad Manevski, 2019, Drug metabolism letters.

Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat

M. Walles, Nenad Manevski, G. Camenisch, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Orexins and the treatment of obesity.

J. Arch, A. Haynes, D. Smart, 2002, European journal of pharmacology.

Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma.

D. Budd, S. Watson, S. Charlton, 2017, ACS medicinal chemistry letters.

Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1 Antagonist

F. Picard, O. Kretz, R. Stringer, 2014, Drug Metabolism and Disposition.

Functional assessment of rat pulmonary flavin-containing monooxygenase activity

S. Krähenbühl, M. Walles, Nenad Manevski, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

The in vitro metabolism of sphingosine-1-phosphate: identification; inhibition and pharmacological implications.

M. Dowling, S. Charlton, M. Bradley, 2011, European journal of pharmacology.

7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.

C. Leblanc, D. Budd, S. Watson, 2009, Bioorganic & medicinal chemistry letters.

2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists.

S. Whitebread, C. Leblanc, D. Budd, 2007, Bioorganic & medicinal chemistry letters.

Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding.

Nigel J Waters, N. Waters, Rachel Jones, 2008, Journal of pharmaceutical sciences.

Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.

Paul J. Groot-Kormelink, D. Rowlands, H. Danahay, 2021, Journal of medicinal chemistry.

Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases.

Cerys Docx, J. Westwick, C. Leblanc, 2013, Bioorganic & medicinal chemistry.

Evaluation of relative MS response factors of drug metabolites for semi-quantitative assessment of chemical liabilities in drug discovery.

J. Blanz, P. Ramstein, David Pearson, 2017, Journal of mass spectrometry : JMS.

Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist

E. Weber, R. Stringer, B. Sohal, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP‐TEAD Protein‐Protein Interaction Inhibitors

P. Furet, P. Chène, T. Schmelzle, 2023, ChemMedChem.

Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension.

T. Troxler, S. Cotesta, D. Rowlands, 2023, Journal of medicinal chemistry.

Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding.

N. Waters, B. Sohal, Gareth Williams, 2008, Journal of pharmaceutical sciences.