Darlene B. Royce

发表

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.

M. Sporn, A. Place, N. Suh, 2005, Cancer research.

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities

M. Sporn, N. Suh, A. Dinkova-Kostova, 2007, Molecular Cancer Therapeutics.

Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A.

M. Sporn, N. Suh, K. Liby, 2006, Bioorganic & medicinal chemistry letters.

Pegylated interferon beta in the treatment of the Theiler's murine encephalomyelitis virus mouse model of multiple sclerosis

F. Gilli, Krista D DiSano, A. Pachner, 2017, Journal of Neuroimmunology.

Treatment of Theiler’s virus-induced demyelinating disease with teriflunomide

F. Gilli, Krista D DiSano, A. Pachner, 2017, Journal of NeuroVirology.

Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.

M. Sporn, M. Cao, K. Liby, 2015, Pharmacological research.

Sustained Release Talazoparib Implants for Localized Treatment of BRCA1-deficient Breast Cancer

Anne L. van de Ven, R. Kumar, K. Liby, 2017, Theranostics.

A New Rexinoid, NRX194204, Prevents Carcinogenesis in Both the Lung and Mammary Gland

M. Sporn, K. Liby, R. Chandraratna, 2007, Clinical Cancer Research.

ANew Rexinoid , NRX 194204 , Prevents Carcinogenesis in Both the Lung andMammary Gland

K. Liby, R. Chandraratna, M. Wood, 2007 .

The Synthetic Triterpenoid CDDO-Imidazolide Suppresses STAT Phosphorylation and Induces Apoptosis in Myeloma and Lung Cancer Cells

M. Sporn, J. Letterio, K. Liby, 2006, Clinical Cancer Research.

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

M. Sporn, J. Morrow, M. Beal, 2009, PloS one.

The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.

M. Sporn, L. Gediya, V. Njar, 2013, Carcinogenesis.

Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis

F. Gilli, A. Pachner, Michael R. Linzey, 2019, Journal of Neuroinflammation.

The Synthetic Triterpenoid CDDO-Methyl Ester Delays Estrogen Receptor–Negative Mammary Carcinogenesis in Polyoma Middle T Mice

M. Sporn, K. Liby, Charlotte R. Williams, 2012, Cancer Prevention Research.

Prevention and Treatment of Experimental Estrogen Receptor – Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268

M. Sporn, A. Albini, M. Yore, 2008, Clinical Cancer Research.

Community composition and the environment modulate the population dynamics of type VI secretion in human gut bacteria

C. Nadell, Daniel Schultz, Evan Trus, 2023, bioRxiv.

The Combination of the Rexinoid, LG100268, and a Selective Estrogen Receptor Modulator, Either Arzoxifene or Acolbifene, Synergizes in the Prevention and Treatment of Mammary Tumors in an Estrogen Receptor–Negative Model of Breast Cancer

M. Sporn, P. Brown, S. Krajewski, 2006, Clinical Cancer Research.

The SyntheticTriterpenoid CDDO-Imidazolide Suppresses STAT Phosphorylation and Induces Apoptosis in Myeloma and Lung Cancer Cells

M. Sporn, K. Liby, T. Honda, 2006 .

The Selective Estrogen Receptor Modulator Arzoxifene and the Rexinoid LG100268 Cooperate to Promote Transforming Growth Factor β-Dependent Apoptosis in Breast Cancer

M. Sporn, A. Berchuck, John Calvin Reed, 2004, Cancer Research.

Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.

M. Sporn, K. Liby, I. Pitha-Rowe, 2009, Investigative ophthalmology & visual science.

CDDO-Methyl Ester Delays Breast Cancer Development in Brca1-Mutated Mice

M. Sporn, Eun-Hee Kim, C. Deng, 2011, Cancer Prevention Research.

Triterpenoids CDDO-Methyl Ester or CDDO-Ethyl Amide and Rexinoids LG100268 or NRX194204 for Prevention and Treatment of Lung Cancer in Mice

M. Sporn, M. Yore, K. Liby, 2009, Cancer Prevention Research.

The PARP Inhibitors, Veliparib and Olaparib, Are Effective Chemopreventive Agents for Delaying Mammary Tumor Development in BRCA1-deficient Mice

M. Sporn, Eun-Hee Kim, K. Liby, 2014, Cancer Prevention Research.

Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.

M. Sporn, K. Liby, P. Pioli, 2017, Cancer letters.

Central Nervous System Inflammatory Aggregates in the Theiler's Virus Model of Progressive Multiple Sclerosis

F. Gilli, A. Pachner, Darlene B. Royce, 2019, Front. Immunol..

Clinical utility of a molecular signature in inflammatory demyelinating disease

F. Gilli, A. Pachner, Darlene B. Royce, 2018, Neurology: Neuroimmunology & Neuroinflammation.

Synthetic Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer

M. Sporn, R. Hruban, A. Maitra, 2010, Cancer Prevention Research.

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.

M. Sporn, E. Dmitrovsky, M. Yore, 2007, Cancer research.

Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis.

M. Sporn, C. Ringelberg, K. Liby, 2015, Carcinogenesis.

A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.

M. Sporn, J. Groopman, T. Kensler, 2008, Cancer research.

The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice

M. Sporn, M. Cao, K. Liby, 2015, Cancer Prevention Research.

The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis

M. Sporn, E. Dmitrovsky, M. Yore, 2008, Molecular Cancer Therapeutics.

Intestinal Bacteroides Modulates Systemic Inflammation and the Microbial Ecology in a Mouse Model of CF: Evidence for Propionate and other Short Chain Fatty Acids Reducing Systemic Inflammatory Cytokines

J. Schwartzman, J. Bliska, Courtney E. Price, 2022, bioRxiv.

Interaction of PEGylated interferon‐beta with antibodies to recombinant interferon‐beta

F. Gilli, A. Pachner, Darlene B. Royce, 2018, International immunopharmacology.

Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis

F. Gilli, A. Pachner, Michael R. Linzey, 2019, Journal of neuroinflammation.

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis.

F. Gilli, A. Pachner, Darlene B. Royce, 2016, Journal of visualized experiments : JoVE.

thetic Triterpenoids Prolong Survival in a Transgenic Pr R se Model of Pancreatic Cancer

M. Sporn, A. Maitra, Charlotte R. Williams, 2010 .

Triterpenoids CDDO-Methyl Ester or CDDO-Ethyl Amide and Rexinoids LG100268 or NRX194204 for Prevention and Treatment of Lung Cancer in Mice

M. Sporn, M. Yore, K. Liby, 2009, Cancer Prevention Research.