M. Kanda

发表

Synthesis and Biological Evaluation of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acids: A Novel Series of PPARγ Agonists

Kenji Takahashi, C. Mukai, Satoru Azukizawa, 2008 .

Role of intracellular Ca2+ in endothelium-dependent contraction and relaxation of rabbit intrapulmonary arteries.

H. Shirahase, K. Kurahashi, Shohei Nakamura, 2003, Life sciences.

Endothelium‐dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2

H. Shirahase, H. Usui, K. Kurahashi, 1995, British journal of pharmacology.

Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells.

Tomohiro Miike, K. Kunishiro, H. Shirahase, 2008, Life sciences.

NK1 receptor-mediated endothelium-dependent relaxation and contraction with different sensitivity to post-receptor signaling in pulmonary arteries.

Tomohiro Miike, K. Kunishiro, H. Shirahase, 2009, Vascular pharmacology.

Regional heterogeneity of substance P-induced endothelium-dependent contraction, relaxation, and -independent contraction in rabbit pulmonary arteries.

Tomohiro Miike, K. Kunishiro, H. Shirahase, 2008, Life sciences.

Endothelium‐dependent relaxation followed by contraction mediated by NK1 receptors in precontracted rabbit intrapulmonary arteries

H. Shirahase, K. Kurahashi, S. Nakamura, 2000, British journal of pharmacology.

Impairment of endothelium-dependent ACh-induced relaxation in aorta of diabetic db/db mice—possible dysfunction of receptor and/or receptor–G protein coupling

Satoru Azukizawa, Tomohiro Miike, K. Kunishiro, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

A novel series of thromboxane A2 synthetase inhibitors with free radical scavenging and anti-peroxidative activities.

A. Yoshimi, M. Kasai, H. Shirahase, 2001, Chemical & pharmaceutical bulletin.

Somatostatin-induced contraction mediated by endothelial TXA2 production in canine cerebral arteries.

O. Rorstad, H. Shirahase, H. Usui, 1993, Life sciences.

Protective Effects of Iganidipine on Morphological and Functional Changes of Arteries in Hypertensive Dahl Rats

Y. Uehara, H. Shirahase, A. Ichikawa, 1998, Journal of cardiovascular pharmacology and therapeutics.

Synthesis and biological evaluation of (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: a novel series of PPAR gamma agonists.

Kenji Takahashi, C. Mukai, Satoru Azukizawa, 2008, Chemical & pharmaceutical bulletin.

Endothelium-dependent contraction induced by substance P in canine cerebral arteries: involvement of NK1 receptors and thromboxane A2.

H. Shirahase, K. Kurahashi, S. Nakamura, 1998, Life sciences.

Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid.

M. Ohta, Kenji Takahashi, K. Kunishiro, 2008, Journal of medicinal chemistry.

Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition.

Mamoru Kanda, Kazuya Otake, Satoru Azukizawa, 2012, Bioorganic & medicinal chemistry.

Hypolipidemic and Antioxidant Activity of the Novel Acyl-CoA:Cholesterol Acyltransferase (ACAT) Inhibitor KY-455 in Rabbits and Hamsters

A. Yoshimi, H. Shirahase, K. Kurahashi, 2004, Arzneimittelforschung.

[Influence of indapamide on isolated rabbit arteries (author's transl)].

N. Toda, H. Usui, M. Kanda, 1978, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

On the production of the KrF - and XeF - Ion beams for the tandem electrostatic accelerators

E. Minehara, S. Hanashima, M. Kanda, 1984 .

Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice.

E. Hinoi, Masaki Fukui, H. Shirahase, 2018, Journal of pharmacological sciences.

Inhibitory effects of PGD2, PGJ2 and 15-deoxy-delta12,14-PGJ2 on iNOS induction in rat mesenteric artery.

Y. Uehara, H. Shirahase, A. Ichikawa, 2000, Life sciences.

Synergistic Effect of Nitric Oxide Synthase and Cyclooxygenase Inhibitors on Carrageenan-induced Paw Edema in Rats

Y. Uehara, K. Kunishiro, H. Shirahase, 2006, Arzneimittelforschung.

Effect of combination of nitric oxide synthase and cyclooxygenase inhibitors on carrageenan-induced pleurisy in rats.

Y. Uehara, K. Kunishiro, H. Shirahase, 2006, Life sciences.

Effects of selective iNOS inhibition on type II collagen-induced arthritis in mice.

Y. Uehara, H. Shirahase, A. Ichikawa, 2004, Life sciences.

Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition.

Kazuya Otake, Satoru Azukizawa, Masaki Fukui, 2012, Bioorganic & medicinal chemistry.

Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA: cholesterol acyltransferase and lipid peroxidation.

Kenji Takahashi, C. Mukai, Tomohiro Miike, 2010, Chemical & pharmaceutical bulletin.

Novel acyl-CoA: cholesterol acyltransferase inhibitor: indoline-based sulfamide derivatives with low lipophilicity and protein binding ratio.

Kenji Takahashi, Tomohiro Miike, K. Kunishiro, 2010, Chemical & pharmaceutical bulletin.

Novel indoline-based acyl-CoA: cholesterol acyltransferase inhibitor: Effects of introducing a methanesulfonamide group on physicochemical properties and biological activities.

Kenji Takahashi, K. Kunishiro, M. Kasai, 2009, Bioorganic & medicinal chemistry.