D. Needham

发表

Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation.

S. Hodgson, D. Hall, P. Procopiou, 2012, Bioorganic & medicinal chemistry letters.

Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.

Birgit Dümpelfeld, James M. Woolven, S. Teague, 2021, Journal of medicinal chemistry.

Discovery of GW870086: a potent anti‐inflammatory steroid with a unique pharmacological profile

S. Farrow, I. Uings, K. Biggadike, 2013, British journal of pharmacology.

Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.

A. Hill, D. Clapham, S. Hodgson, 2013, Journal of medicinal chemistry.

Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivity.

H. T. Jones, I. McLay, G. Hardy, 2007, Journal of medicinal chemistry.

Efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF3-substituted tertiary alcohols

H. T. Jones, G. Hardy, D. Coe, 2008 .

Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing.

K. Biggadike, D. Holmes, P. Procopiou, 2014, Journal of medicinal chemistry.

The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group.

P. Procopiou, V. Barrett, G. Somers, 2011, Bioorganic & medicinal chemistry.

Lead Optimization of the N1 Substituent of a Novel Series of Indazole Arylsulfonamides as CCR4 Antagonists and Identification of a Candidate for Clinical Investigation.

S. Hodgson, D. Hall, P. Procopiou, 2012 .