Simon Corbett

Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin.

Gary C. Kemp, J. Hartley, Sanjay Nilapwar, 2017, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload.

J. Hartley, David G. Williams, A. Tiberghien, 2016, ACS medicinal chemistry letters.

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

J. Hartley, P. V. van Berkel, S. Mao, 2018, Scientific Reports.

Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer

N. Bander, E. Corey, R. Tammali, 2018, Molecular Cancer Therapeutics.

The Role of Specific ATP-Binding Cassette Transporters in the Acquired Resistance to Pyrrolobenzodiazepine Dimer–Containing Antibody–Drug Conjugates

J. Hartley, P. V. van Berkel, P. Howard, 2020, Molecular Cancer Therapeutics.

ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies.

T. Marafioti, J. Hartley, P. V. van Berkel, 2018, Blood.

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

J. Hartley, P. V. van Berkel, S. Mao, 2018, Scientific Reports.