L. Simpkins

发表

Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.

N. Trippodo, H. Cheung, R. Misra, 1997, Journal of medicinal chemistry.

Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors.

R. Parker, L. Hamann, M. Kirby, 2005, Bioorganic & medicinal chemistry letters.

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

H. Jamil, D. Gordon, T. Harrity, 2001, Journal of medicinal chemistry.

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.

R. Parker, L. Hamann, M. Kirby, 2007, Bioorganic & medicinal chemistry letters.

N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.

K. Kish, L. Hamann, A. Fura, 2009, Journal of medicinal chemistry.

Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors.

C. Weigelt, L. Hamann, M. Kirby, 2010, Bioorganic & medicinal chemistry letters.

Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

R. Parker, L. Hamann, M. Kirby, 2005, Journal of medicinal chemistry.

Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptides

J. Barrish, N. Murugesan, N. Trippodo, 1994 .

Peptidomimetic Synthesis: A Novel, Highly Stereoselective Route to Substituted Freidinger Lactams

J. Robl, H. Weller, M. Malley, 1994 .

Dual metalloprotease inhibitors. 6. Incorporation of bicyclic and substituted monocyclic azepinones as dipeptide surrogates in angiotensin-converting enzyme/neutral endopeptidase inhibitors.

N. Trippodo, J. Robl, T. Schaeffer, 1996, Journal of medicinal chemistry.

Vasopeptidase inhibitors: incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides.

N. Trippodo, E. Sieber-McMaster, J. Robl, 1999, Journal of medicinal chemistry.

Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis.

E. Gordon, T. Harrity, M. Sofia, 1990, Journal of medicinal chemistry.

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

David S. Taylor, R. Parker, R. Stoffel, 2007, Bioorganic & medicinal chemistry letters.

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.

H. Jamil, C. Chu, R. Gregg, 1998, Science.

N-formyl hydroxylamine containing dipeptides: generation of a new class of vasopeptidase inhibitors.

J. Robl, M. Asaad, L. Simpkins, 2000, Bioorganic & medicinal chemistry letters.

DUAL METALLOPROTEASE INHIBITORS. III: UTILIZATION OF BICYCLIC AND MONOCYCLIC DIAZEPINONE BASED MERCAPTOACETYLS

J. Barrish, N. Trippodo, J. Robl, 1994 .

Dual metalloprotease inhibitors. II. Effect of substitution and stereochemistry on benzazepinone based mercaptoacetyls

N. Trippodo, R. Misra, E. Sieber-McMaster, 1994 .

1-Acyltriazoles as antiinflammatory agents.

T. P. Kissick, L. Simpkins, R. Millonig, 1982, Journal of medicinal chemistry.

1-ACYLTRIAZOLES AS ANTIINFLAMMATORY AGENTS

T. P. Kissick, L. Simpkins, R. Millonig, 1982 .

Phosphorus-Containing Inhibitors of HMG-CoA Reductase. Part 1. 4-((2- Arylethyl)hydroxyphosphinyl)-3-hydroxybutanoic Acids: A New Class of Cell-Selective Inhibitors of Cholesterol Biosynthesis.

E. Gordon, T. Harrity, M. Sofia, 1991 .

Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors.

R. Parker, L. Hamann, D. Augeri, 2004, Journal of medicinal chemistry.

Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).

L. Hamann, R. Seethala, D. Gordon, 2011, Bioorganic & medicinal chemistry letters.

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

Akbar Nayeem, Haixia Wang, Steven Sheriff, 2008, Bioorganic & medicinal chemistry letters.

Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).

L. Hamann, R. Seethala, D. Gordon, 2011, Bioorganic & medicinal chemistry letters.