Y. Takai

发表

Localization of the Rab3 Small G Protein Regulators in Nerve Terminals and Their Involvement in Ca2+-dependent Exocytosis*

M. Wada, Takuya Sasaki, H. Nakanishi, 1998, The Journal of Biological Chemistry.

Molecular Cloning and Characterization of the Noncatalytic Subunit of the Rab3 Subfamily-specific GTPase-activating Protein*

Takuya Sasaki, F. Nagano, T. Asakura, 1998, The Journal of Biological Chemistry.

Involvement of Rabphilin3 in Endocytosis through Interaction with Rabaptin5*

Takuya Sasaki, T. Ohya, Masaki Kato, 1998, The Journal of Biological Chemistry.

Roles of Cell-Cell Adhesion-dependent Tyrosine Phosphorylation of Gab-1*

K. Tachibana, T. Matozaki, A. Kodama, 2001, The Journal of Biological Chemistry.

Afadin regulates actomyosin organization through alpha E-catenin at adherens junctions

S. Yonemura, Ayumu Sugiura, Kiyohito Mizutani, 2021 .

Identification of lysophosphatidic acid in serum as a factor that promotes epithelial apical junctional complex organization

Kiyohito Mizutani, M. Shinohara, Muneaki Miyata, 2022, The Journal of biological chemistry.

Doc2α is an activity‐dependent modulator of excitatory synaptic transmission

S. Itohara, T. Manabe, Katsunori Kobayashi, 1999, The European journal of neuroscience.

Synamon, a Novel Neuronal Protein Interacting with Synapse-associated Protein 90/Postsynaptic Density-95-associated Protein*

Y. Hata, M. Takeuchi, K. Hirao, 1999, The Journal of Biological Chemistry.

MAGUIN, a Novel Neuronal Membrane-associated Guanylate Kinase-interacting Protein*

Y. Hata, K. Hirao, I. Yao, 1999, The Journal of Biological Chemistry.

Rab3A small GTP‐binding protein in Ca2+‐dependent exocytosis

H. Shirataki, Takuya Sasaki, H. Nakanishi, 1996, Genes to cells : devoted to molecular & cellular mechanisms.

Interaction of Nectin with Afadin Is Necessary for Its Clustering at Cell-Cell Contact Sites but Not for Itscis Dimerization or trans Interaction*

K. Tachibana, H. Nakanishi, Kenichi Takahashi, 2000, The Journal of Biological Chemistry.

Clustering and Enhanced Activity of an Inwardly Rectifying Potassium Channel, Kir4.1, by an Anchoring Protein, PSD-95/SAP90*

Y. Hata, Y. Horio, Y. Kurachi, 1997, The Journal of Biological Chemistry.

Membrane‐associated guanylate kinase with inverted orientation (MAGI)‐1/brain angiogenesis inhibitor 1‐associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions

A. Mino, T. Ohtsuka, E. Inoue, 2000, Genes to cells : devoted to molecular & cellular mechanisms.

BEGAIN (Brain-enriched Guanylate Kinase-associated Protein), a Novel Neuronal PSD-95/SAP90-binding Protein*

Y. Hata, Y. Takai, M. Irie, 1998, The Journal of Biological Chemistry.

T. Sasaki, Y. Takai, T. Sakisaka, 1999, Genes to cells : devoted to molecular & cellular mechanisms.

Isolation and Characterization of a GTPase Activating Protein Specific for the Rab3 Subfamily of Small G Proteins*

T. Sasaki, K. Fukui, Y. Takai, 1997, The Journal of Biological Chemistry.

Complex Formation of SMAP/KAP3, a KIF3A/B ATPase Motor-associated Protein, with a Human Chromosome-associated Polypeptide*

Y. Takai, T. Honda, K. Shimizu, 1998, The Journal of Biological Chemistry.

Interaction of Bnr1p with a Novel Src Homology 3 Domain-containing Hof1p

M. Umikawa, H. Imamura, M. Kikyo, 1998, The Journal of Biological Chemistry.

Nectin-3, a New Member of Immunoglobulin-like Cell Adhesion Molecules That Shows Homophilic and Heterophilic Cell-Cell Adhesion Activities*

K. Tachibana, H. Nakanishi, Kenichi Takahashi, 2000, The Journal of Biological Chemistry.

Neurabin-II/Spinophilin

Y. Hata, K. Hirao, Y Takai, 1998, The Journal of Biological Chemistry.

Association of synapse‐associated protein 90/ postsynaptic density‐95‐associated protein (SAPAP) with neurofilaments

Y. Takai, A. Mizoguchi, H. Kawabe, 2000, Genes to cells : devoted to molecular & cellular mechanisms.

Three Isoforms of Synaptic Scaffolding Molecule and Their Characterization

Y. Hata, K. Hirao, I. Yao, 2000, The Journal of Biological Chemistry.

Anchoring proteins confer G protein sensitivity to an inward‐rectifier K+ channel through the GK domain

Y. Hata, Y. Kurachi, Y. Takai, 2000, EMBO Journal.

Association of Frabin with the Actin Cytoskeleton Is Essential for Microspike Formation through Activation of Cdc42 Small G Protein*

Y. Matsuura, I. Hotta, M. Umikawa, 1999, The Journal of Biological Chemistry.

Frabin, a Novel FGD1-related Actin Filament-binding Protein Capable of Changing Cell Shape and Activating c-Jun N-terminal Kinase*

H. Nakanishi, K. Mandai, A. Satoh, 1998, The Journal of Biological Chemistry.

Rab11BP/Rabphilin-11, a Downstream Target of Rab11 Small G Protein Implicated in Vesicle Recycling*

A. Mammoto, I. Hotta, Takuya Sasaki, 1999, The Journal of Biological Chemistry.

Comparison of kinetic properties between MSS4 and Rab3A GRF GDP/GTP exchange proteins

T. Sasaki, Y. Takai, K. Takahashi, 1994, FEBS letters.

Physical and Functional Interactions of Doc2 and Munc13 in Ca2+-dependent Exocytotic Machinery*

Takuya Sasaki, H. Igarashi, S. Orita, 1997, The Journal of Biological Chemistry.

s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons

T. Kuriu, Kiyohito Mizutani, Muneaki Miyata, 2023, The Journal of biological chemistry.

Localization of l‐afadin at puncta adhaerentia‐like junctions between the mossy fiber terminals and the dendritic trunks of pyramidal cells in the adult mouse hippocampus

K. Kimura, H. Nakanishi, K. Mandai, 2000, The Journal of comparative neurology.

Control of reorganization of the actin cytoskeleton by Rho family small GTP-binding proteins in yeast.

K. Tanaka, Y. Takai, Y. Takai, 1998, Current opinion in cell biology.

Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin.

Y. Hata, Y. Takai, Y. Hata, 1999, Biochemical and biophysical research communications.

Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae.

K Tanaka, K. Tanaka, Y. Takai, 1996, The EMBO journal.

Binding of neuroligins to PSD-95.

T. Südhof, Y. Hata, Y. Takai, 1997, Science.

Small G-protein networks: their crosstalk and signal cascades.

T Matozaki, T. Matozaki, Y. Takai, 2000, Cellular signalling.

Requirement of nectin, but not cadherin, for formation of claudin-based tight junctions in annexin II-knockdown MDCK cells

K. Irie, R. Okamoto, Y. Takai, 2006, Oncogene.

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway

T. Sasaki, M. Monden, N. Sato, 1996, The Journal of cell biology.

Localization of Rabphilin-3A on the synaptic vesicle.

T. Sasaki, C. Ide, Y. Takai, 1994, Biochemical and biophysical research communications.

Localization of rabphilin-3A, a putative target protein for Rab3A, at the sites of Ca(2+)-dependent exocytosis in PC12 cells.

C. Ide, K. Kaibuchi, Y. Takai, 1994, Biochemical and biophysical research communications.

Localization of smg p25A/rab3A p25, a small GTP-binding protein, at the active zone of the rat neuromuscular junction.

C. Ide, Y. Takai, A. Mizoguchi, 1992, Biochemical and biophysical research communications.

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

H. Kitayama, K. Kaibuchi, M. Matsuda, 1995, Molecular and cellular biology.

Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission.

T. Sasaki, J. Miyoshi, H. Kamiya, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells.

C. Wollheim, P. Morel, Y. Takai, 1996, Journal of cell science.

Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.

T. Sasaki, M. Zerial, K. Kaibuchi, 1993, The Journal of biological chemistry.

Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis.

S. Nishikawa, J. Miyoshi, Y. Takai, 1999, The Journal of cell biology.

Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction.

T. Sasaki, T. Nagano, J. Miyoshi, 2001, Molecular biology of the cell.

Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.

T. Sasaki, Y. Hata, S. Kuroda, 1990, The Journal of biological chemistry.

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

T. Sasaki, S. Kuroda, K. Kaibuchi, 1992, The Journal of biological chemistry.

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin

K. Kaibuchi, S. Kishida, Y. Takai, 1993, Molecular and cellular biology.

Rho as a regulator of the cytoskeleton.

T. Sasaki, K. Tanaka, Y. Takai, 1995, Trends in biochemical sciences.

Enhancement of the actions of smg p21 GDP/GTP exchange protein by the protein kinase A-catalyzed phosphorylation of smg p21.

Y. Hata, K. Kaibuchi, Y. Takai, 1991, The Journal of biological chemistry.

The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control.

T. Sasaki, Y. Takai, Y Takai, 1998, Biochemical and biophysical research communications.

A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.

Y. Nishizuka, Y. Takai, K. Sano, 1983, The Journal of biological chemistry.

Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae.

T Watanabe, K Tanaka, Y. Ohya, 1996, The EMBO journal.

A downstream target of RHO1 small GTP‐binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.

K. Tanaka, Y. Takai, H. Kohno, 1995, The EMBO journal.

rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells

T. Sasaki, Y. Takai, Y. Matsuura, 1994, Molecular and cellular biology.

Shs1p: a novel member of septin that interacts with spa2p, involved in polarized growth in saccharomyces cerevisiae.

K. Tanaka, Y. Takai, A. Mino, 1998, Biochemical and biophysical research communications.

Possible involvement of protein kinase C and calcium ion in growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.

K. Kaibuchi, Y. Takai, T. Yamashita, 1986, The Journal of biological chemistry.

Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.

T. Sasaki, Y. Takai, S. Tsukita, 1995, Oncogene.

Phospholipid turnover in hormone action.

Y. Nishizuka, K. Kaibuchi, U. Kikkawa, 1984, Recent progress in hormone research.

Interactions of drebrin and gephyrin with profilin.

T. Sasaki, T. Shirao, A. Mammoto, 1998, Biochemical and biophysical research communications.

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI)

Y. Takai, K. Kishi, Takuya Sasaki, 1993, The Journal of cell biology.

SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.

Y. Takai, M. Irie, Y. Hata, 1997, The Journal of biological chemistry.

Counteraction of calcium-activated, phospholipid-dependent protein kinase activation by adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in platelets.

Y. Nishizuka, K. Kaibuchi, Y. Takai, 1982, Journal of biochemistry.

Phosphorylation of Rabphilin-3A, a putative target protein for Rab3A, by cyclic AMP-dependent protein kinase.

T. Yamamoto, Y. Takai, H. Shirataki, 1994, Biochemical and biophysical research communications.

Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes

T. Sasaki, Y. Takai, A. Kikuchi, 1992, Molecular and cellular biology.

Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins.

K. Kaibuchi, M. Asada, E. Tomhave, 1992, Biochemical and biophysical research communications.

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

K. Kaibuchi, T. Yamamoto, Y. Takai, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Interaction of cancer cells with platelets mediated by Necl-5/poliovirus receptor enhances cancer cell metastasis to the lungs

M. Okada, Y. Takai, T. Imai, 2008, Oncogene.

Synergistic functions of phorbol ester and calcium in serotonin release from human platelets.

Y. Nishizuka, K. Kaibuchi, M. Castagna, 1983, Biochemical and biophysical research communications.

Interleukin 2 activation of cytotoxic T-lymphocytes infiltrating into human metastatic melanomas.

C. Balch, R. Paladugu, K. Itoh, 1986, Cancer research.

A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase.

K. Kaibuchi, A. Maeda, T. Yamamoto, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Mitosis-specific phosphorylation of vimentin by protein kinase C coupled with reorganization of intracellular membranes

Y. Taketani, M. Inagaki, O. Tsutsumi, 1996, The Journal of cell biology.

Three splicing variants of tomosyn and identification of their syntaxin-binding region.

Y. Takai, T. Sakisaka, H. Shirataki, 1999, Biochemical and biophysical research communications.

Rabphilin-3A: A Multifunctional Regulator of Synaptic Vesicle Traffic

T. Sasaki, G. Augustine, Y. Takai, 1998, The Journal of general physiology.

Localization and subcellular distribution of smg p25A, a ras p21-like GTP-binding protein, in rat brain.

N. Hirokawa, Y. Takai, A. Mizoguchi, 1990, The Journal of biological chemistry.

Nucleotide and deduced amino acid sequences of a GTP-binding protein family with molecular weights of 25,000 from bovine brain.

Y. Takai, J. Kondo, Y. Teranishi, 1988, The Journal of biological chemistry.

Purification and characterization of a novel GTP-binding protein with a molecular weight of 24,000 from bovine brain membranes.

K. Ikeda, Y. Takai, T. Yamashita, 1988, The Journal of biological chemistry.

Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase.

T. Sasaki, F. McCormick, K. Kaibuchi, 1992, The Journal of biological chemistry.

Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.

K. Kaibuchi, Y. Takai, A. Kikuchi, 1991, Oncogene.

Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.

T. Sasaki, Y. Hata, J. Gibbs, 1990, The Journal of biological chemistry.

Rho and Rab small G proteins coordinately reorganize stress fibers and focal adhesions in MDCK cells.

T. Sasaki, M. Monden, H. Shiozaki, 1998, Molecular biology of the cell.

Role of the C-terminal region of smg p25A in its interaction with membranes and the GDP/GTP exchange protein

T. Sasaki, Y. Hata, K. Kaibuchi, 1991, Molecular and cellular biology.

Rab3A-rabphilin-3A system in neurotransmitter release.

T. Sasaki, Y. Takai, H. Shirataki, 1997, Advances in second messenger and phosphoprotein research.

The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins.

C. Wollheim, Y. Takai, A. Kikuchi, 1992, The Journal of biological chemistry.

A mammalian inhibitory GDP/GTP exchange protein (GDP dissociation inhibitor) for smg p25A is active on the yeast SEC4 protein

T. Sasaki, P. Novick, K. Kaibuchi, 1991, Molecular and cellular biology.

Purification and characterization from rat liver cytosol of a GDP dissociation inhibitor (GDI) for liver 24K G, a ras p21-like GTP-binding protein, with properties similar to those of smg p25A GDI.

Y. Takai, Y. Takeyama, H. Ohyanagi, 1991, Biochemistry.

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein

Y. Hata, Y. Takai, S. Araki, 1990, Molecular and cellular biology.

Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.

Y. Takai, A. Kikuchi, Y Takai, 1990, The Journal of biological chemistry.

Tissue and subcellular distributions of an inhibitory GDP/GTP exchange protein (GDI) for smg p25A by use of its antibody.

K. Kaibuchi, Y. Takai, K. Shimizu, 1991, Biochemical and biophysical research communications.

Differential targeting of protein kinase C and CaM kinase II signalings to vimentin

N. Inagaki, S. Hirai, S. Ohno, 1995, The Journal of cell biology.

Possible involvement of protein kinase C in interleukin-1 production by mouse peritoneal macrophages.

T. Matsui, K. Kaibuchi, Y. Takai, 1986, Biochemical and biophysical research communications.

Inhibitory action of guanosine 3', 5'-monophosphate on thrombin-induced phosphatidylinositol turnover and protein phosphorylation in human platelets.

Y. Nishizuka, K. Kaibuchi, Y. Takai, 1981, Biochemical and biophysical research communications.

Widespread occurrence of calcium-activated, phospholipid-dependent protein kinase in mammalian tissues.

Y. Nishizuka, Y. Takai, B. Yu, 1981, Journal of biochemistry.

Consequences of weak interaction of rho GDI with the GTP-bound forms of rho p21 and rac p21.

T. Sasaki, Y. Takai, Y Takai, 1993, The Journal of biological chemistry.

Membrane phospholipid turnover, receptor function and protein phosphorylation.

Y. Nishizuka, K. Kaibuchi, U. Kikkawa, 1982, Progress in brain research.

Characterization of cyclic nucleotide-independent protein kinase produced enzymatically from its proenzyme by calcium-dependent neutral protease from rat liver.

Y. Takai, Akira Kishimoto, Yasutomi Nishizuka, 1978, Journal of biochemistry.

Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation.

P. Greengard, A. Nairn, H. Hemmings, 1999, Biochemistry.

A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13.

T. Sasaki, Y. Takai, S. Orita, 1998, Biochemical and biophysical research communications.

Rabphilin-3A is associated with synaptic vesicles through a vesicle protein in a manner independent of Rab3A.

T. Yamamoto, Y. Takai, H. Shirataki, 1994, The Journal of biological chemistry.

Identification as beta-adducin of a protein interacting with rabphilin-3A in the presence of Ca2+ and phosphatidylserine.

A. Tsugita, K. Kaibuchi, Y. Takai, 1994, Biochemical and biophysical research communications.

Two functionally different domains of rabphilin-3A, Rab3A p25/smg p25A-binding and phospholipid- and Ca(2+)-binding domains.

K. Kaibuchi, S. Kishida, Y. Takai, 1993, The Journal of biological chemistry.

Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.

K. Kaibuchi, T. Yamamoto, Y. Takai, 1991, Molecular and cellular biology.

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

K. Kaibuchi, Y. Takai, S. Araki, 1990, Oncogene.

A geranylgeranyltransferase for rhoA p21 distinct from the farnesyltransferase for ras p21S.

Y. Takai, H. Horiuchi, M. Kawata, 1991, Biochemical and biophysical research communications.

Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration

Y. Kawasaki, T. Akiyama, T. Natsume, 2009, Oncogene.

Angiotensin II induces expression of the c-fos gene through protein kinase C activation and calcium ion mobilization in cultured vascular smooth muscle cells.

Y. Takai, H. Fukuzaki, Y. Fukumoto, 1988, Biochemical and biophysical research communications.

Doc2: a novel brain protein having two repeated C2-like domains.

T. Sasaki, Y. Takai, R. Komuro, 1995, Biochemical and biophysical research communications.

Activation of Rac by cadherin through the c-Src–Rap1–phosphatidylinositol 3-kinase–Vav2 pathway

M. Inagaki, H. Ogita, Y. Takai, 2006, Oncogene.

Possible involvement of protein kinase C in platelet-derived growth factor-stimulated DNA synthesis in vascular smooth muscle cells.

K. Kariya, Y. Takai, H. Fukuzaki, 1987, Atherosclerosis.

[31] Calcium-activated, phospholipid-dependent protein kinase (protein kinase C) from rat brain

Y. Nishizuka, U. Kikkawa, Y. Takai, 1983 .

Elevation of intracellular calcium ion by prostaglandin E1 and its inhibition by protein kinase C in a human megakaryocyte leukemia cell line.

M. Adachi, Y. Takai, M. Hoshijima, 1989, Cancer research.

Elevation of Intracellular Calcium Ion by Prostaglandin E, and Its Inhibition by Protein Kinase C in a Human Megakaryocyte Leukemia Cell Line

Y. Takai, A. Yoshida, Keisuke Teshigawara, 2006 .

Involvement of Rabphilin-3A in cortical granule exocytosis in mouse eggs

T. Sasaki, A. Mammoto, M. Tokunaga, 1996, The Journal of cell biology.