Yoko Takashina

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

H. Utsumi, S. Kiuchi, Yoshinobu Nakamaru, 2012, Bioorganic & medicinal chemistry.

Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice

H. Saito, Mitsuhiro Watanabe, Yoshimasa Saito, 2018, Oncotarget.

Lead optimization of [( S )-γ-(arylamino)prolyl]thiazolidine focused on γ-substituent: Indoline compounds as potent DPP-IV inhibitors

S. Ono, H. Sakashita, H. Kitajima, 2007 .

RNAi-mediated knockdown of mouse melanocortin-4 receptor in vitro and in vivo, using an siRNA expression construct based on the mir-187 precursor

K. Ui-Tei, Aya Juni, K. Saigo, 2016, Experimental animals.

Role of bile acids in the regulation of the metabolic pathways.

Kohkichi Morimoto, Mitsuhiro Watanabe, Y. Yokoyama, 2016, World journal of diabetes.

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

H. Utsumi, S. Kiuchi, Yoshinobu Nakamaru, 2012, Bioorganic & medicinal chemistry.

Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: Indoline compounds as potent DPP-IV inhibitors.

S. Ono, H. Sakashita, H. Kitajima, 2007, Bioorganic & medicinal chemistry.