Tanya Paquet

发表

Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines.

K. Chibale, Dale Taylor, M. Witty, 2015, Journal of medicinal chemistry.

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.

E. Winzeler, S. Meister, K. Chibale, 2016, Journal of medicinal chemistry.

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.

E. Winzeler, S. Meister, K. Chibale, 2015, Journal of medicinal chemistry.

Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials

K. Chibale, D. Mancama, D. Leroy, 2018, The Journal of antimicrobial chemotherapy.

Synthesis of the macrocyclic core of leiodermatolide.

I. Paterson, S. M. Dalby, Tanya Paquet, 2011, Organic Letters.

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.

K. Chibale, Dale Taylor, K. Wicht, 2018, Journal of medicinal chemistry.

Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.

K. Chibale, M. Witty, S. Charman, 2013, Journal of medicinal chemistry.

2,4-Diaminothienopyrimidines as orally active antimalarial agents.

K. Chibale, Dale Taylor, M. Witty, 2014, Journal of medicinal chemistry.

Total synthesis and configurational validation of (+)-phorbaside A.

I. Paterson, Tanya Paquet, 2010, Organic letters.

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801.

K. Saliba, E. Strauss, W. V. van Otterlo, 2019, MedChemComm.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

R. Price, K. Chibale, Dale Taylor, 2018, Antimicrobial Agents and Chemotherapy.

Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum

K. Chibale, Xavier C Ding, D. Leroy, 2013, Malaria Journal.

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

David M. Shackleford, G. Drewes, M. Bantscheff, 2017, Science Translational Medicine.

Antimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library.

K. Chibale, M. Witty, Richard Gordon, 2012, Future medicinal chemistry.

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2.

K. Chibale, Dale Taylor, M. Witty, 2014, Journal of medicinal chemistry.

Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.

C. Eyermann, K. Chibale, Dale Taylor, 2018, Journal of medicinal chemistry.

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.

K. Chibale, T. Egan, Dale Taylor, 2020, Journal of medicinal chemistry.

Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria

K. Chibale, Dale Taylor, G. Basarab, 2018, Antimicrobial Agents and Chemotherapy.

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.

C. Eyermann, K. Chibale, Dale Taylor, 2018, Journal of medicinal chemistry.

Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics

G. Drewes, M. Bantscheff, K. Chibale, 2014, Malaria Journal.

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.

E. Winzeler, K. Chibale, Dale Taylor, 2021, Journal of medicinal chemistry.