H. Ohnota

发表

Effect of a non‐sulphonylurea hypoglycaemic agent, KAD‐1229 on hormone secretion in the isolated perfused pancreas of the rat

Y. Ajisawa, M. Kinukawa, H. Ohnota, 1996, British journal of pharmacology.

Normalization of impaired glucose tolerance by the short-acting hypoglycemic agent calcium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate dihydrate (KAD-1229) in non-insulin-dependent diabetes mellitus rats.

Y. Momose, T. Koizumi, M. Kobayashi, 1995, Canadian journal of physiology and pharmacology.

Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene.

Y. Yazaki, Y. Terauchi, T. Kadowaki, 1996, Biochemical and biophysical research communications.

Analysis of the Pancreatic β Cell in the Mouse with Targeted Disruption of the Pancreatic β Cell-Specific Glucokinase Gene

Y. Yazaki, Y. Terauchi, T. Kadowaki, 1996 .

A rapid- and short-acting hypoglycemic agent KAD-1229 improves post-prandial hyperglycemia and diabetic complications in streptozotocin-induced non-insulin-dependent diabetes mellitus rats.

S. Hamano, N. Shibata, A. Ujiie, 1996, Japanese journal of pharmacology.

In vitro insulinotropic action of a new non-sulfonylurea hypoglycemic agent, calcium (2s)-2-benzyl-3-(cis-hexahydro-2-isoindolinyl-carbonyl) propionate dihydrate (KAD-1229), in rat pancreatic B-cells.

T. Koizumi, M. Kobayashi, F. Sato, 1995, Biochemical pharmacology.

Mutated GM‐CSF‐based CAR‐T cells targeting CD116/CD131 complexes exhibit enhanced anti‐tumor effects against acute myeloid leukaemia

Y. Nakazawa, Aiko Hasegawa, K. Matsuda, 2020, Clinical & translational immunology.

Inhibitory effects of KAT-681, a liver-selective thyromimetic, on development of hepatocellular proliferative lesions in rats induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation

K. Mitsumori, H. Moriwaki, J. Kuroda, 2004, Archives of Toxicology.

Impaired Autophagy in Retinal Pigment Epithelial Cells Induced from iPS Cells obtained from a Patient with Sialidosis

K. Kawai, Yasuyuki Suzuki, Y. Sekijima, 2017 .

Suppression of HIV-1 Replication by a 4-H-Quinolizine Derivative

H. Ushijima, S. Morikawa, T. Kitamura, 1991 .

Inhibition of ATP-sensitive K+ channel by a non-sulfonylurea compound KAD-1229 in a pancreatic beta-cell line, MIN 6 cell.

J. Miyazaki, H. Mogami, H. Shibata, 1994, European journal of pharmacology.

Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia.

K. Ichikawa, Tomonaga Ozawa, K. Hashizume, 2012, Bioorganic & medicinal chemistry.

Design, synthesis, and structure-activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptor β (TRβ) selective agonists.

K. Ichikawa, Tomonaga Ozawa, K. Hashizume, 2013, Bioorganic & medicinal chemistry.

Structure-activity relationship studies of 5-benzylaminoimidazo[1,2-c]pyrimidine-8-carboxamide derivatives as potent, highly selective ZAP-70 kinase inhibitors.

K. Miyazawa, Hiroaki Kobayashi, Motoyasu Ozawa, 2009, Bioorganic & medicinal chemistry.

Structure-activity relationship studies of imidazo[1,2-c]pyrimidine derivatives as potent and orally effective Syk family kinases inhibitors.

K. Miyazawa, Hiroaki Kobayashi, E. Tsuji, 2008, Bioorganic & medicinal chemistry.

Novel pyrazolo[1,5-a]pyrimidines as c-Src kinase inhibitors that reduce IKr channel blockade.

Tomonaga Ozawa, H. Mukaiyama, Toshihiro Nishimura, 2008, Bioorganic & medicinal chemistry.

Discovery of novel 2-anilinopyrazolo[1,5-a]pyrimidine derivatives as c-Src kinase inhibitors for the treatment of acute ischemic stroke.

E. Tsuji, H. Mukaiyama, Toshihiro Nishimura, 2007, Chemical & pharmaceutical bulletin.

A novel Syk family kinase inhibitor: design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives.

K. Miyazawa, Hiroaki Kobayashi, Motoyasu Ozawa, 2008, Bioorganic & medicinal chemistry.

Different inhibitory effects in the early and late phase of treatment with KAT-681, a liver-selective thyromimetic, on rat hepatocarcinogenesis induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation.

K. Mitsumori, J. Kuroda, Y. Kashida, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

3'-Azido-3'-deoxythymidine prevents induction of murine acquired immunodeficiency syndrome in C57BL/10 mice infected with LP-BM5 murine leukemia viruses, a possible animal model for antiretroviral drug screening

H. Ushijima, K. Komuro, T. Kitamura, 1990, Antimicrobial Agents and Chemotherapy.

Isolation of human erythropoietin with monoclonal antibodies.

R. Sasaki, M. Ueda, H. Chiba, 1984, The Journal of biological chemistry.

Protein deficiency impairs erythropoiesis in rats by reducing serum erythropoietin concentration and the population size of erythroid precursor cells.

R. Sasaki, M. Okano, H. Ohnota, 1992, The Journal of nutrition.

Dietary Protein-induced Changes of the Erythropoietin Level in Rat Serum

R. Sasaki, H. Chiba, S. Yanagawa, 1985 .

Novel rapid- and short-acting hypoglycemic agent, a calcium(2s)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) that acts on the sulfonylurea receptor: comparison of effects between KAD-1229 and gliclazide.

T. Koizumi, M. Kobayashi, F. Sato, 1994, The Journal of pharmacology and experimental therapeutics.

Anterior Segment Intraocular Inflammation Guidelines

J. Alió, L. Caspers, D. Benezra, 2000 .

Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice

K. Hongo, D. Sasayama, Nobuhiro Sugiyama, 2017, Scientific Reports.

Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia.

K. Ichikawa, Tomonaga Ozawa, K. Hashizume, 2012, Bioorganic & medicinal chemistry.

Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice

K. Hongo, D. Sasayama, Nobuhiro Sugiyama, 2017, Scientific Reports.

Skeletal muscle cells derived from mouse skin cultures.

Y. Sekijima, T. Honda, A. d’Azzo, 2020, Biochemical and biophysical research communications.