P. Hemsley

发表

Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors

Edward W. Tate, James S. Scott, Charlie N Saunders, 2020, ACS chemical biology.

Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.

J. Unitt, Bryan E. Roberts, A. Baxter, 2017, ACS medicinal chemistry letters.

Rapid analysis of lipoxygenase products of arachidonic acid by high-performance liquid chromatography

P. Hemsley, C. Hallam, D. Wilkinson, 1985 .

Development of a Scintillation Proximity Assay for Calcineurin Phosphatase Activity

E. Sullivan, P. Hemsley, A. Pickard, 1997 .

Hydroxamates Myeloperoxidase by Aromatic Potent Reversible Inhibition of Enzymology

J. Unitt, A. Kettle, T. Sjögren, 2014 .

Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates*

G. Pairaudeau, J. Unitt, A. Kettle, 2013, The Journal of Biological Chemistry.

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.

Fiona Pachl, A. Pike, M. O’Connor, 2021, Journal of medicinal chemistry.

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1

Paul Hemsley, Joseph Shaw, Ian Dale, 2018, SLAS discovery : advancing life sciences R & D.

The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger

Anu J. Tervo, G. Pairaudeau, A. Ward, 2011, ChemMedChem.

Ligand Discovery: High-Throughput Binding: Fluorescence Polarization (Anisotropy).

G. Holdgate, P. Hemsley, 2021, Methods in molecular biology.

Abstract LB-273: A head-to-head comparison of the properties of five clinical PARP inhibitors identifies new insights that can explain both the observed clinical efficacy and safety profiles

Fiona Pachl, M. O’Connor, Glen Hawthorne, 2018, Experimental and Molecular Therapeutics.

An evaluation of fluorescence polarization and lifetime discriminated polarization for high throughput screening of serine/threonine kinases.

Paul Hemsley, John Unitt, J. Unitt, 2002, Analytical biochemistry.

Inhibition of platelet 12-lipoxygenase by hydroxy-fatty acids

P. Hemsley, C. Hallam, D. Wilkinson, 1984 .