Ahmed Alshawi

Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge

David M. Smith, L. Agius, C. Cano, 2020, Diabetes, obesity & metabolism.

Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism

L. Agius, Ahmed Alshawi, 2018, The Journal of Biological Chemistry.

Opposite effects of a glucokinase activator and metformin on glucose‐regulated gene expression in hepatocytes

Z. Al-Oanzi, H. Reeves, L. Agius, 2017, Diabetes, obesity & metabolism.

Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation

B. Viollet, Z. Al-Oanzi, M. Cascante, 2020, The Journal of Biological Chemistry.

Compromised chronic efficacy of a Glucokinase Activator AZD1656 in mouse models for common human GCKR variants

S. Chachra, Ahmed Alshawi, Brian E. Ford, 2024, bioRxiv.