V. Mouchlis

发表

Lipoprotein-associated phospholipase A2: A paradigm for allosteric regulation by membranes

Varnavas D. Mouchlis, J. Mccammon, E. Dennis, 2022, Proceedings of the National Academy of Sciences.

Inhibition of secreted phospholipases A₂ by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations.

Varnavas D. Mouchlis, George Kokotos, Nathan Cermak, 2011, Bioorganic & medicinal chemistry.

Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity

J. Mccammon, E. Dennis, Yuan Chen, 2018, Journal of the American Chemical Society.

2-Oxoester Phospholipase A2 Inhibitors with Enhanced Metabolic Stability

E. Dennis, G. Kokotos, Giorgos S. Koutoulogenis, 2020, Biomolecules.

Phospholipase A 2 catalysis and lipid mediator lipidomics Cell Biol Lipids.

E. Dennis, V. Mouchlis, 2019 .

Insertion of the Ca 2 + -Independent Phospholipase A 2 into a Phospholipid Bilayer via Coarse-Grained and Atomistic Molecular Dynamics Simulations

J. Mccammon, E. Dennis, Denis Bucher, 2013 .

2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity.

E. Dennis, G. Antonopoulou, V. Magrioti, 2016, Bioorganic & medicinal chemistry.

Vitamin E Functions by Association with a Novel Binding Site on the 67 kDa Laminin Receptor Activating Diacylglycerol Kinase.

Varnavas D. Mouchlis, E. Dennis, Hiroyuki Arai, 2022, The Journal of nutritional biochemistry.

β-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β-Cell Apoptosis.

Varnavas D. Mouchlis, E. Dennis, V. Magrioti, 2019, Journal of medicinal chemistry.

Review of four major distinct types of human phospholipase A2.

Varnavas D. Mouchlis, V. D. Mouchlis, E. Dennis, 2017, Advances in biological regulation.

Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A2 inhibitors.

E. Dennis, V. Mouchlis, C. Mu, 2020, Advances in biological regulation.

Phospholipase A2 catalysis and lipid mediator lipidomics.

Varnavas D. Mouchlis, V. D. Mouchlis, E. Dennis, 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Substrate-Specific Inhibition Constants for Phospholipase A2 Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics

Varnavas D. Mouchlis, E. Dennis, Aaron M. Armando, 2019, Journal of medicinal chemistry.

2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2

Varnavas D. Mouchlis, E. Dennis, Aaron R Navratil, 2017, Scientific Reports.

Advances in De Novo Drug Design: From Conventional to Machine Learning Methods

Varnavas D. Mouchlis, D. Greco, G. Melagraki, 2021, International journal of molecular sciences.

Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships.

Varnavas D. Mouchlis, J. Mccammon, E. Dennis, 2016, Journal of medicinal chemistry.

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics

Varnavas D. Mouchlis, V. D. Mouchlis, G. Melagraki, 2020, International journal of molecular sciences.

Molecular Modeling on Pyrimidine-Urea Inhibitors of TNF-α Production: An Integrated Approach Using a Combination of Molecular Docking, Classification Techniques, and 3D-QSAR CoMSIA

George Kollias, Georgia Melagraki, Thomas M. Mavromoustakos, 2012, J. Chem. Inf. Model..

Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A2s

Varnavas D. Mouchlis, E. Dennis, Daiki Hayashi, 2021, Journal of lipid research.

Membrane Association Allosterically Regulates Phospholipase A2 Enzymes and Their Specificity

Varnavas D. Mouchlis, E. Dennis, V. Mouchlis, 2022, Accounts of chemical research.

Each Phospholipase A2 Type Exhibits Distinct Selectivity Toward sn-1 Ester, Alkyl Ether, and Vinyl Ether Phospholipids.

Varnavas D. Mouchlis, E. Dennis, Daiki Hayashi, 2021, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates

Varnavas D. Mouchlis, J. Mccammon, E. Dennis, 2015, Proceedings of the National Academy of Sciences.

Insertion of the Ca2+-Independent Phospholipase A2 into a Phospholipid Bilayer via Coarse-Grained and Atomistic Molecular Dynamics Simulations

Varnavas D. Mouchlis, Edward A. Dennis, James Andrew McCammon, 2013, PLoS Comput. Biol..

Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor

Thomas M. Mavromoustakos, Varnavas D. Mouchlis, George Kokotos, 2010, J. Comput. Aided Mol. Des..

Molecular Docking and 3D-QSAR CoMFA Studies on Indole Inhibitors of GIIA Secreted Phospholipase A2

Thomas M. Mavromoustakos, Varnavas D. Mouchlis, George Kokotos, 2010, J. Chem. Inf. Model..

Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches.

Ivan Rusyn, Georgia Melagraki, Alexander Tropsha, 2013, Toxicology and applied pharmacology.

Membrane and inhibitor interactions of intracellular phospholipases A2.

Varnavas D. Mouchlis, V. D. Mouchlis, E. Dennis, 2016, Advances in biological regulation.

Binding Conformation of 2-Oxoamide Inhibitors to Group IVA Cytosolic Phospholipase A2 Determined by Molecular Docking Combined with Molecular Dynamics

Thomas M. Mavromoustakos, Varnavas D. Mouchlis, Vasiliki Michopoulou, 2012, J. Chem. Inf. Model..

Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2.

J Andrew McCammon, Varnavas D. Mouchlis, Sheng Li, 2016, Bioorganic & medicinal chemistry.

Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2)

Varnavas D. Mouchlis, E. Dennis, G. Kokotos, 2018, ACS omega.

2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A2 inhibitors.

E. Dennis, G. Kokotos, E. Barbayianni, 2017, Bioorganic & medicinal chemistry.

Binding of novel fullerene inhibitors to HIV-1 protease: insight through molecular dynamics and molecular mechanics Poisson–Boltzmann surface area calculations

Serdar Durdagi, Manthos G. Papadopoulos, Thomas M. Mavromoustakos, 2011, J. Comput. Aided Mol. Des..

The rise of targeting chimeras (TACs): next-generation medicines that preempt cellular events

Varnavas D. Mouchlis, Dahlia R. Weiss, V. Shanmugasundaram, 2023, Medicinal Chemistry Research.

The application of rational design on phospholipase A(2) inhibitors.

T. Mavromoustakos, G. Kokotos, E. Barbayianni, 2011, Current medicinal chemistry.