C. Franklin

发表

Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.

Howard Y. Chen, R. Nargund, M. Wyvratt, 2010, Bioorganic & medicinal chemistry letters.

Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.

M. Reibarkh, Howard Y. Chen, R. Nargund, 2010, Bioorganic & medicinal chemistry letters.

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.

D. Macintyre, Howard Y. Chen, R. Nargund, 2010, Bioorganic & medicinal chemistry letters.

A Nitrogen-Assisted One-Pot Heteroaryl Ketone Synthesis from Carboxylic Acids and Heteroaryl Halides.

Lei Zhu, E. O'brien, Frederick A. Hicks, 2016, The Journal of organic chemistry.

A novel class of zinc-binding inhibitors for the phosphatidylcholine-preferring phospholipase C from Bacillus cereus.

P. Hergenrother, B. Follows, S. F. Martín, 2000, The Journal of organic chemistry.

Design, synthesis, and evaluation of water-soluble phospholipid analogues as inhibitors of phospholipase C from Bacillus cereus.

S. Martin, Hui Li, C. Franklin, 2003, The Journal of organic chemistry.

Using X-ray crystallography of the Asp55Asn mutant of the phosphatidylcholine-preferring phospholipase C from Bacillus cereus to support the mechanistic role of Asp55 as the general base.

A. Monzingo, J. Robertus, Stephen F. Martin, 2003, Archives of biochemistry and biophysics.

Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.

M. Reitman, J. Metzger, O. Palyha, 2011, ACS medicinal chemistry letters.

Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.

Howard Y. Chen, R. Nargund, M. Wyvratt, 2010, Bioorganic & Medicinal Chemistry Letters.