J. Tarr

发表

Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.

Brian A. Chauder, Bruce J. Melancon, D. Sheffler, 2012, Bioorganic & medicinal chemistry letters.

Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.

D. Sheffler, C. Lindsley, C. Hopkins, 2013, Bioorganic & medicinal chemistry letters.

Monitoring the Speciation of Aqueous Free Chlorine from pH 1 to 12 with Raman Spectroscopy to Determine the Identity of the Potent Low-pH Oxidant

T. Collette, Stephen E. Duirk, Daniel P. Cherney, 2006, Applied spectroscopy.

Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides.

Bruce J. Melancon, N. Brandon, C. Lindsley, 2017, Bioorganic & medicinal chemistry letters.

Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.

N. Brandon, C. Lindsley, P. Conn, 2016, Bioorganic & medicinal chemistry letters.

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.

Alison R. Gregro, Julie L. Engers, Bruce J. Melancon, 2016, Bioorganic & medicinal chemistry letters.

Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides.

N. Brandon, C. Lindsley, Hyekyung P. Cho, 2017, Bioorganic & medicinal chemistry letters.

Highly reactive catalysts for aerobic thioether oxidation the Fe-substituted polyoxometalate/hydrogen dinitrate system

C. Hill, K. Hardcastle, J. C. Tarr, 2006 .

Lanthanum tricyanide-catalyzed acyl silane-ketone benzoin additions and kinetic resolution of resultant alpha-silyloxyketones.

J. Tarr, Jeffrey S. Johnson, 2010, The Journal of organic chemistry.

Lanthanum tricyanide-catalyzed acyl silane-ketone benzoin additions.

J. Tarr, Jeffrey S. Johnson, 2009, Organic letters.

Enantioselective metallophosphite-catalyzed C-acylation of nitrones.

M. R. Garrett, J. Tarr, Jeffrey S. Johnson, 2007, Journal of the American Chemical Society.

Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease.

Craig W Lindsley, Bruce J. Melancon, Bruce J Melancon, 2013, Drug discovery today.

Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

Bruce J. Melancon, J. Wess, N. Brandon, 2014, ACS chemical neuroscience.

Phosphodiesterase 10 A Regulates Alcohol and Saccharin Self-Administration in Rats

Robert L Barry, John C Gore, P Jeffrey Conn, 2014 .

Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.

E. Olejniczak, S. Fesik, O. Rossanese, 2016, Journal of medicinal chemistry.

Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design.

E. Olejniczak, S. Fesik, O. Rossanese, 2018, Journal of medicinal chemistry.

Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.

Anna L. Blobaum, D. Sheffler, C. Lindsley, 2012, ACS chemical neuroscience.

Allosteric modulation of the M 1 muscarinic acetylcholine receptor : improving cognition and a potential treatment for schizophrenia and Alzheimer ’ s disease

Bruce J. Melancon, C. Lindsley, Joseph D. Panarese, 2013 .

Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.

Bruce J. Melancon, N. Brandon, C. Lindsley, 2017, Bioorganic & medicinal chemistry letters.

Fragment-based screening of programmed death ligand 1 (PD-L1).

E. Olejniczak, S. Fesik, Bin Zhao, 2019, Bioorganic & medicinal chemistry letters.

Chlorpyrifos transformation by aqueous chlorine in the presence of bromide and natural organic matter.

T. Collette, Stephen E. Duirk, J. Tarr, 2008, Journal of agricultural and food chemistry.

Discovery and biological characterization of potent myeloid cell leukemia‐1 inhibitors

A. Letai, E. Olejniczak, S. Fesik, 2017, FEBS letters.

Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.

D. Sheffler, Z. Xiang, C. Lindsley, 2011, Bioorganic & medicinal chemistry letters.

Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.

E. Olejniczak, S. Fesik, J. Opferman, 2019, Journal of medicinal chemistry.

PD-L1 IgV domain V76T with fragment

E. Olejniczak, S. Fesik, Bin Zhao, 2019 .

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Stephen M. Damon, A. Deutch, J. Wess, 2014, Neuropsychopharmacology.

Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule.

D. Sheffler, C. Lindsley, Margrith E. Mattmann, 2013, Bioorganic & medicinal chemistry letters.