Hongbin Yuan

发表

Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation

John Calvin Reed, Brock T Brown, G. Roth, 2011, ACS medicinal chemistry letters.

A Novel Pharmacophore Model for the Design of Anthrax Lethal Factor Inhibitors

M. Pellecchia, Jun Wei, Sherida L. Johnson, 2010, Chemical biology & drug design.

BI‐69A11‐mediated inhibition of AKT leads to effective regression of xenograft melanoma

S. Krajewski, G. Robertson, Z. Ronai, 2009, Pigment cell & melanoma research.

Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs

John Calvin Reed, K. Welsh, K. Vuori, 2013, Molecular Cancer Therapeutics.

DUSP3 Phosphatase Deficiency or Inhibition Limit Platelet Activation and Arterial Thrombosis Running title: Musumeci et al.; DUSP3, a new player in arterial thrombosis

T. Mustelin, T. Chung, E. Théâtre, 2014 .

Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase.

Elisa Barile, Maurizio Pellecchia, Hongbin Yuan, 2009, Journal of medicinal chemistry.

Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits.

A. Kozikowski, K. Kellar, Yingxian Xiao, 2005, Journal of medicinal chemistry.

Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders.

A. Kozikowski, P. Mcgonigle, I. Gaisina, 2007, Journal of the American Chemical Society.

Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors.

M. Pellecchia, E. Barile, Jun Wei, 2009, Bioorganic & medicinal chemistry.

Discovery and Binding Studies on a Series of Novel Pin1 Ligands

M. Pellecchia, Bainan Wu, Jun Wei, 2009, Chemical biology & drug design.

Dual-Specificity Phosphatase 3 Deficiency or Inhibition Limits Platelet Activation and Arterial Thrombosis

T. Mustelin, T. Chung, E. Théâtre, 2014, Circulation.

Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.

John Calvin Reed, K. Welsh, K. Vuori, 2011, Bioorganic & medicinal chemistry letters.

Different Residues Mediate Recognition of 1-O-Oleyllysophosphatidic Acid and Rosiglitazone in the Ligand Binding Domain of Peroxisome Proliferator-activated Receptor γ*

Satoshi Yasuda, Hongbin Yuan, Daniel L Baker, 2006, Journal of Biological Chemistry.

Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

Li Yang, Maurizio Pellecchia, Hongbin Yuan, 2009, Journal of medicinal chemistry.

Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins

John Calvin Reed, S. Sebti, M. Pellecchia, 2009, Molecular Cancer Therapeutics.

Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists.

John Calvin Reed, M. Pellecchia, S. Kitada, 2009, Cancer letters.

Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation

T. Mustelin, T. Chung, Li Yang, 2012, ACS chemical biology.

DUSP 3 Phosphatase Deficiency or Inhibition Limit Platelet Activation and Arterial Thrombosis

T. Mustelin, T. Chung, E. Théâtre, 2014 .

Small Molecule DnaK Modulators Targeting the β‐Domain

M. Pellecchia, Si Wang, Bainan Wu, 2009, Chemical biology & drug design.

Sphingosine 1-phosphate and lysophosphatidic acid receptors: agonist and antagonist binding and progress toward development of receptor-specific ligands.

A. Parrill, V. Sardar, Hongbin Yuan, 2004, Seminars in cell & developmental biology.

Background—A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. A better understanding of the molecular mechanisms leading to platelet activation is important for the development of improved therapies. Recently, protein tyrosine p

T. Mustelin, T. Chung, E. Théâtre, 2015 .

Discovery of 2-arylamino-4-(1-methyl-3-isopropylsulfonyl-4-pyrazol-amino)pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.

B. Zhong, Gang-Ying Chen, Ruihao Zhang, 2015, Bioorganic & medicinal chemistry letters.

Receptor-Based Modeling and 3D-QSAR for a Quantitative Production of the Butyrylcholinesterase Inhibitors Based on Genetic Algorithm

Reaz Uddin, Jeffry D. Madura, Mohammad Iqbal Choudhary, 2008, J. Chem. Inf. Model..

Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors.

M. Pellecchia, E. Barile, S. De, 2009, Bioorganic & medicinal chemistry.

Small-Molecule Inhibitors of Vaccinia-H1-Related Phosphatase VHR

T. Mustelin, T. Chung, E. Sergienko, 2010 .

Chemical Medicine: Novel 10‐Substituted Cytisine Derivatives with Increased Selectivity for α4β2 Nicotinic Acetylcholine Receptors

A. Kozikowski, K. Kellar, Yingxian Xiao, 2007 .

Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors.

A. Kozikowski, K. Kellar, Yingxian Xiao, 2007, ChemMedChem.

Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors.

David C Lankin, Hongbin Yuan, Yong Shen, 2009, Bioorganic & medicinal chemistry letters.

Improved 3D-QSAR CoMFA of the dopamine transporter blockers with multiple conformations using the genetic algorithm.

Hongbin Yuan, P. Petukhov, Pavel A Petukhov, 2006, Bioorganic & medicinal chemistry letters.

Cluster analysis and three-dimensional QSAR studies of HIV-1 integrase inhibitors.

A. Parrill, Hongbin Yuan, 2005, Journal of molecular graphics & modelling.

Table 1, PubChem Assay Summaries for Probe project

Darren Finlay, Robert Ardecky, Thomas D.Y. Chung, 2010 .

Computational evidence for the ligand selectivity to the α4β2 and α3β4 nicotinic acetylcholine receptors

P. Petukhov, Hongbin Yuan, 2006 .

QSAR studies of HIV-1 integrase inhibition.

Hongbin Yuan, Abby L Parrill, A. Parrill, 2002, Bioorganic & medicinal chemistry.

Design and synthesis of novel 3-sulfonylpyrazol-4-amino pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.

B. Zhong, Gang-Ying Chen, Ruihao Zhang, 2016, Bioorganic & medicinal chemistry letters.

Discovery and Binding Studies on a Series of Novel Pin1 Ligands

M. Pellecchia, Bainan Wu, Jun Wei, 2009, Chemical biology & drug design.

High Throughput Screening Assays for NOD1 Inhibitors - Probe 2

John Calvin Reed, T. Chung, Brock T Brown, 2010 .