A. Lebsack

发表

A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors*

M. Milla, T. Mirzadegan, M. Hack, 2016, The Journal of Biological Chemistry.

Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.

S. Venkatraman, B. Muñoz, Bowei Wang, 2009, Bioorganic & medicinal chemistry letters.

Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids.

Stephen M. Canham, L. Overman, Sangkil Nam, 2015, Tetrahedron.

Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the α2δ-1 subunit of voltage gated calcium channel

S. Venkatraman, J. Gunzner, B. Muñoz, 2004 .

Scale-Up Synthesis of a TRPV1 Antagonist Featuring a Facile Thiazolo[5,4-d]pyrimidine Formation

N. Mani, Jing Liu, A. Lebsack, 2011 .

Enantioselective total synthesis of quadrigemine C and psycholeine.

L. Overman, J. T. Link, B. Stearns, 2002, Journal of the American Chemical Society.

Enantioselective total synthesis of shahamin K.

L. Overman, A. Lebsack, R. Valentekovich, 2001, Journal of the American Chemical Society.

Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.

Hong Ao, A. Bhattacharya, M. Hack, 2010, Bioorganic & medicinal chemistry letters.

Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.

John J. M. Wiener, Jennifer D. Venable, Jianmei Wei, 2021, ACS medicinal chemistry letters.

Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.

Taraneh Mirzadegan, Michael D Hack, Alec D Lebsack, 2017, Journal of medicinal chemistry.

Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.

M. Peterson, Hong Ao, A. Bhattacharya, 2009, Bioorganic & medicinal chemistry letters.

Accelerating Lead Identification by High Throughput Virtual Screening: Prospective Case Studies from the Pharmaceutical Industry

John J. M. Wiener, Nidhi Arora, James P Edwards, 2019, J. Chem. Inf. Model..

Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist.

Hong Ao, A. Bhattacharya, A. Wickenden, 2011, European journal of pharmacology.

1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties.

Hong Ao, A. Bhattacharya, A. Wickenden, 2010, Bioorganic & medicinal chemistry letters.

1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido [4,5-d]azepines as TRPV1 Antagonists with Improved Properties.

A. Lebsack, 2011 .

Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform

C. Dvorak, Jiejun Wu, M. Milla, 2016, Journal of biomolecular screening.

The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.

Hong Ao, A. Bhattacharya, A. Wickenden, 2016, Bioorganic & medicinal chemistry letters.

Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.

John J. M. Wiener, Jennifer D. Venable, Jianmei Wei, 2022, Journal of medicinal chemistry.

Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform

C. Dvorak, Jiejun Wu, M. Milla, 2016, Journal of biomolecular screening.