Steven Magnuson

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CBP/p300 drives the differentiation of Regulatory T cells through transcriptional and non-transcriptional mechanisms.

W. Jones, K. Hutchinson, J. Giltnane, 2019, Cancer research.

Conversion of some substituted phenols to the corresponding masked thiophenols, synthesis of a dinickel(II) dithiolate macrocyclic complex and isolation of some metal- and ligand-based oxidation products

C. Ralston, S. Cramer, S. Brooker, 2000 .

Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors.

A. Isacchi, E. Felder, R. D'Alessio, 2014, Journal of medicinal chemistry.

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.

Adam R. Johnson, Jun Liang, J. DeVoss, 2017, Bioorganic & medicinal chemistry letters.

GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.

A. Good, P. Sandy, Y. Leblanc, 2022, Journal of medicinal chemistry.

GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2).

P. Sandy, H. Jayaram, R. Sims, 2017, ACS medicinal chemistry letters.

Revealed by Novel TYK2-Selective Inhibitors Activity in Human Cytokine Responses A Restricted Role for TYK2 Catalytic

Adam R. Johnson, N. Lewin-Koh, Lawren C. Wu, 2013 .

Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.

Fei Wang, F. A. Romero, E. Choo, 2018, Bioorganic & medicinal chemistry letters.

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.

Karen E Gascoigne, Fei Wang, S. Kharbanda, 2016, Journal of medicinal chemistry.

In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.

K. B. Clairmont, W. Wong, Terri Witman-Jones, 2004, Bioorganic & medicinal chemistry letters.

Steric and Electronic Factors Influence Regio‐isomeric Thiazole Formations Between Substituted Benzothioamides and Ethyl Bromopyruvate

Jun Liang, Birong Zhang, Yingjie Lai, 2014 .

Two-directional synthesis and its use in natural product synthesis

Steven Magnuson, 1995 .

Two-directional synthesis and its use in natural product synthesis

Steven Magnuson, 1995 .

Synthesis of the sesquiterpene (±)-ceratopicanol: Use of radicals derived from epoxides

D. Clive, Steven Magnuson, 1995 .

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.

Adam R. Johnson, Jun Liang, J. DeVoss, 2013, Journal of medicinal chemistry.

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.

M. Ultsch, C. Eigenbrot, Leslie B. Lee, 2013, Bioorganic & medicinal chemistry letters.

Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships.

A. Isacchi, E. Casale, T. O'Brien, 2013, Journal of medicinal chemistry.

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

Adam R. Johnson, Jun Liang, N. Lewin-Koh, 2013, The Journal of Immunology.

A concise total synthesis of dysidiolide through application of a dioxolenium-mediated Diels-Alder reaction

N. Rosen, L. Sepp-Lorenzino, S. Danishefsky, 1998 .

Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.

Jane R Kenny, Michael Siu, Deepak Sampath, 2012, Journal of medicinal chemistry.

A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists.

M. Volgraf, Jun Chen, S. Shields, 2021, ACS medicinal chemistry letters.

Efficient syntheses of 2-fluoroalkylbenzimidazoles and -benzothiazoles

Steven R. Magnuson, B. Fauber, Olivier René, 2013 .

Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.

Thomas V. O'brien, P. Trojer, D. Stokoe, 2016, Cancer research.

Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.

Karen E Gascoigne, S. Kharbanda, R. Raisner, 2018, Cell reports.

Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors.

F. A. Romero, Alexander M. Taylor, A. Côté, 2016, Journal of medicinal chemistry.

Cyclopentannulation by an Iterative Process of Sequential Claisen Rearrangement and Enyne Radical Closure: Routes to Triquinane and Propellane Systems and Use in the Synthesis of (±)-Ceratopicanol

D. Clive, Steven Magnuson, D. Mayhew, 1996 .

Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.

Karen E Gascoigne, Z. Modrušan, S. Kharbanda, 2017, Cancer research.

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).

Y. Leblanc, H. Jayaram, R. Sims, 2016, ACS medicinal chemistry letters.

Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance.

D. Stokoe, P. Sandy, Steffan Vartanian, 2017, Bioorganic & medicinal chemistry letters.

Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).

B. Fauber, Steven Magnuson, B. Fauber, 2014, Journal of medicinal chemistry.

Lead identification of novel and selective TYK2 inhibitors.

Adam R. Johnson, Jun Liang, M. Ultsch, 2013, European journal of medicinal chemistry.

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

S. Krauss, M. Merchant, P. Polakis, 2013, Cancer research.

A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel

M. Volgraf, Tianbo Li, A. Rohou, 2020, Neuron.

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition*

G. Hatzivassiliou, P. Sandy, H. Jayaram, 2016, The Journal of Biological Chemistry.

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.

M. Volgraf, A. Rohou, Jun Chen, 2021, Journal of medicinal chemistry.

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).

Karen E Gascoigne, Y. Ran, G. Hatzivassiliou, 2017, Journal of medicinal chemistry.

A new regulatory switch in a JAK protein kinase

Charles Eigenbrot, Vickie Tsui, Paul Gibbons, 2011, Proteins.

A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors.

Fei Wang, H. Jayaram, F. A. Romero, 2017, Journal of medicinal chemistry.

Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.

Anthony M Giannetti, Ping Wu, Brandon J. Bravo, 2014, Bioorganic & medicinal chemistry letters.

Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.

Adam R. Johnson, Lawren C. Wu, C. Eigenbrot, 2014, Bioorganic & medicinal chemistry letters.

Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation.

Karen E Gascoigne, Z. Modrušan, D. Arnott, 2019, Cell reports.

GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.

H. Jayaram, F. A. Romero, R. Cummings, 2018, Journal of medicinal chemistry.

Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.

Andrew C Good, Vickie Tsui, Jian Wang, 2016, Journal of medicinal chemistry.

Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors.

J. Blaney, Jianping Yin, B. Pan, 2015, Bioorganic & medicinal chemistry letters.

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Simon S. Gao, J. Elstrott, M. Volgraf, 2021, The Journal of experimental medicine.

Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization.

Anthony M Giannetti, Ping Wu, Brandon J. Bravo, 2014, Journal of medicinal chemistry.

Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs

F. A. Romero, G. Cain, E. Choo, 2020, Toxicologic pathology.

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.

A. Ebens, John G. Moffat, Richard M Pastor, 2013, Bioorganic & medicinal chemistry letters.

Correction for Chernov-Rogan et al., TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism

D. Hackos, Wienke Lange, H. Deisemann, 2020, Proceedings of the National Academy of Sciences.

TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism

M. Klein, M. Volgraf, V. Carnevale, 2019, Proceedings of the National Academy of Sciences.

PDE-10A inhibitors as insulin secretagogues.

Lei Zhu, J. Livingston, T. Claus, 2007, Bioorganic & medicinal chemistry letters.

Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2).

J. Grandner, Steffan Vartanian, John G. Moffat, 2023, ACS medicinal chemistry letters.

A new regulatory switch in a JAK protein kinase

Jun Liang, M. Ultsch, M. Lamers, 2011, Proteins.