D. Price

发表

Peptide vaccination elicits leukemia-associated antigen-specific cytotoxic CD8+ T-cell responses in patients with chronic lymphocytic leukemia

H. Döhner, J. Roliński, E. Gostick, 2010, Leukemia.

Nonspecifically Activate CTLs for Cognate TCR Recognition and Properties Bypass the Requirement Superenhanced CD8 Binding MHC Class I Molecules with

A. Sewell, John J Miles, S. Burrows, 2010 .

MHC Class I Molecules with Superenhanced CD8 Binding Properties Bypass the Requirement for Cognate TCR Recognition and Nonspecifically Activate CTLs

A. Sewell, John J Miles, S. Burrows, 2010, The Journal of Immunology.

Novel Recombinant Mycobacterium bovis BCG, Ovine Atadenovirus, and Modified Vaccinia Virus Ankara Vaccines Combine To Induce Robust Human Immunodeficiency Virus-Specific CD4 and CD8 T-Cell Responses in Rhesus Macaques

D. Douek, V. Venturi, E. Gostick, 2010, Journal of Virology.

T-Cell Responses in Rhesus Immunodeficiency Virus-Specific CD 4 and To Induce Robust Human Vaccinia Virus Ankara Vaccines Combine BCG , Ovine Atadenovirus , and Modified Mycobacterium bovis Novel Recombinant

D. Douek, V. Venturi, E. Gostick, 2010 .

Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells

M. Eberl, Hung-Chang Chen, Jianqiang Li, 2017, Immunology and cell biology.

CD4+ T cells: The great escape

R. Phillips, G. Harcourt, D. Price, 2001, Nature Medicine.

HLA and Peptide Sensitivity Allotypic Dimorphism That Impacts Both KIR3DL1 Reveals a Lineage-Defining Mutational and Structural Analysis of

J. Rossjohn, E. Gostick, S. Anderson, 2014 .

Immunodeficiency Virus into Immune Protection from Simian MHC Class I Molecule Mamu-B*17: Insights Accommodation by the Rhesus Macaque Structural Basis of Diverse Peptide

G. Gao, J. Qi, E. Gostick, 2011 .

Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung

B. Graham, Syed M. Moin, A. Redwood, 2016, Mucosal Immunology.

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting*

Katherine K. Matthews, A. Sewell, B. Baker, 2012, The Journal of Biological Chemistry.

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids

Thomas S. Watkins, J. Altman, J. Rossjohn, 2018, Nature Immunology.

Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8 (cid:2) T-Cell Response to HIV-1

D. Baarle, D. Koning, B. Grady, 2014 .

acute lymphoblastic leukemia specific T lymphocytes after allogeneic stem-cell transplantation for - Graft-versus-leukemia effects associated with detectable Wilms tumor-1

D. Douek, K. Keyvanfar, S. Mielke, 2013 .

leukemia before and after stem cell transplantation exist in healthy individuals and in patients with chronic myelogenous T cells + Functional leukemia-associated antigen-specific memory CD8

J. Brenchley, J. Melenhorst, A. Barrett, 2012 .

CTLs for Cognate TCR Recognition and Properties Bypass the Requirement Superenhanced CD 8 Binding MHC Class I Molecules with

A. Sewell, John J Miles, S. Burrows, 2010 .

and Nonspecifically Activate CTLs Requirement for Cognate TCR Recognition CD8 Binding Properties Bypass the MHC Class I Molecules with Superenhanced

A. Sewell, John J Miles, S. Burrows, 2010 .

Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity.

B. Autran, V. Appay, L. Papagno, 2009, Blood.

acute lymphoblastic leukemia specific T lymphocytes after allogeneic stem-cell transplantation for − Graft-versus-leukemia effects associated with detectable Wilms tumor

D. Douek, K. Rezvani, K. Keyvanfar, 2007 .

Transfer of PR1-specific T-cell clones from donor to recipient by stem cell transplantation and association with GvL activity.

D. Douek, J. Brenchley, K. Rezvani, 2007, Cytotherapy.

T-Cell Responses Directed against Multiple HLA-A*0201-Restricted Epitopes Derived from Wilms' Tumor 1 Protein in Patients with Leukemia and Healthy Donors: Identification, Quantification, and Characterization

D. Douek, J. Brenchley, K. Rezvani, 2005, Clinical Cancer Research.

againstMultiple HLA-A * 0201-Restricted Epitopes Derived fromWilms ’ Tumor 1 Protein in Patients with Leukemia and Healthy Donors : Identification , Quantification , and Characterization

D. Douek, J. Brenchley, K. Rezvani, 2005 .

Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency.

Andrew J. Oler, S. Choo, S. Tangye, 2020, Blood.

Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency

J. McElwee, J. Casanova, S. Tangye, 2017, The Journal of experimental medicine.

Epidermis instructs skin homing receptor expression in human T cells.

R. Mansel, K. Ladell, B. Moser, 2012, Blood.

CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin

K. Ladell, M. Cameron, B. Moser, 2018, The Journal of Immunology.

Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells

M. Roederer, E. Lugli, N. Restifo, 2012, Nature Protocols.

during Cytomegalovirus Infection IL-10 Restricts Memory T Cell Inflation

K. Ladell, E. Gostick, I. Humphreys, 2010 .

Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase.

D. Douek, K. Rezvani, J. Melenhorst, 2004, Blood.

Specific CD8+ T Cell Responses Correlate with Control of Simian Immunodeficiency Virus Replication in Mauritian Cynomolgus Macaques

Melisa L. Budde, D. O’Connor, J. Lifson, 2012, Journal of Virology.

Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells

Nancy R. Zhang, Duc P. Truong, J. Hoxie, 2019, Science Translational Medicine.

Low Human Immunodeﬁciency Virus Envelope Diversity Correlates with Low In Vitro Replication Capacity and Predicts Spontaneous Control of Plasma Viremia after Treatment Interruptions the Swiss HIV Cohort Study

A. Trkola, H. Günthard, R. Weber, 2005 .

Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia.

H. Goossens, G. Juliusson, K. Ladell, 2017, Blood.

Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant

A. Sette, H. Ljunggren, A. Karlsson, 2022, Nature Medicine.

Ancestral SARS-CoV-2-specific T cells cross-recognize Omicron (B.1.1.529)

A. Sette, H. Ljunggren, A. Karlsson, 2022, Nature Network Boston.

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response

G. Screaton, J. Rossjohn, S. Gras, 2017, Nature Immunology.

Frequency Is Linked to Naïve-Precursor T Cell + Hepatitis C Virus-Specific CD8 Immunodominance of HLA-A2-Restricted

E. Gostick, V. Lohmann, R. Thimme, 2014 .

Immunodominance of HLA-A2-Restricted Hepatitis C Virus-Specific CD8+ T Cell Responses Is Linked to Naïve-Precursor Frequency

E. Gostick, V. Lohmann, H. Blum, 2011, Journal of Virology.

Frequency Responses Is Linked to Naïve-Precursor T Cell + Hepatitis C Virus-Specific CD 8 Immunodominance of HLA-A 2-Restricted

E. Gostick, V. Lohmann, H. Blum, 2011 .

CD8 on the Cell Surface and of an Interaction between pMHCI Activation and Occurs in the Absence Paralleled by Their Effects on CTL (pMHCI) Multimer Binding: This Is Enhance Peptide-MHC Class I Anti-CD8 Antibodies Can Inhibit or

S. Hutchinson, V. Cerundolo, L. Wooldridge, 2010 .

Cell Surface andof an Interaction between pMHCI Activation and Occurs in the Absence Paralleled by Their Effects on CTL ( pMHCI ) Multimer Binding : This Is Enhance Peptide-MHC Class I Anti-CD 8 Antibodies Can Inhibit

S. Hutchinson, A. Sewell, V. Cerundolo, 2003 .

Cell Surface Absence of an Interaction between pMHCI on CTL Activation and Occurs in the Binding : This Is Paralleled by Their Effects Peptide-MHC Class I ( pMHCI ) Multimer Anti-CD 8 Antibodies Can Inhibit or Enhance

S. Hutchinson, A. Sewell, V. Cerundolo, 2003 .

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

O. Lund, M. Nielsen, John J Miles, 2014, The Journal of experimental medicine.

TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection

Sagar, E. Gostick, Sian Llewellyn-Lacey, 2020, Gut.

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques.

J. Lifson, J. Brenchley, K. Ladell, 2010, Blood.

Mechanisms underlying (cid:1)(cid:2) T-cell subset perturbations in SIV-infected Asian rhesus macaques

J. Lifson, J. Brenchley, K. Ladell, 2010 .

TO WILMS TUMOR PROTEIN ( WT 1 ) IN MYELODYSPLASIA RESPONSIVE TO IMMUNOSUPPRESSIVE THERAPY ( IST )

D. Douek, J. Brenchley, N. Young, 2010 .

University of Birmingham Clonal selection in the human V1 T cell repertoire indicates TCR-dependent adaptive immune surveillance

D. Chudakov, K. Ladell, J. McLaren, 2017 .

High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay.

Nitin J. Karandikar, R. Koup, D. Douek, 2004, Blood.

A clinical-scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion technique.

K. Rezvani, A. Barrett, E. Gostick, 2008, Blood.

Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex.

G. Gao, J. Bell, T. Georgiou, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Bypassing IgE and targeting T cells for specific immunotherapy of allergy

A. Sewell, D. Price, 2001 .

AIDS virus–specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape

A. Hughes, J. Sidney, A. Sette, 2007, The Journal of experimental medicine.

AIDS virus–specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape

A. Hughes, J. Sidney, A. Sette, 2007, The Journal of experimental medicine.

VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2

F. Luciani, A. Sewell, E. B. Clemens, 2022, Nature Methods.

The MAIT TCRβ chain contributes to discrimination of microbial ligand

K. Ladell, J. McLaren, E. Wong, 2020, Immunology and cell biology.

Heterosubtypic cross‐protection induced by whole inactivated influenza virus vaccine in mice: influence of the route of vaccine administration

E. Gostick, J. Wilschut, A. Huckriede, 2013, Influenza and other respiratory viruses.

Dictated by Cognate Peptide Concentration T Cell Effector Activity Is + Antiviral CD8 The Functional Profile of Primary Human

S. Migueles, M. Connors, R. Koup, 2004 .

Antigen–specific release of β-chemokines by anti-HIV-1 cytotoxic T lymphocytes

S. Rowland-Jones, R. Phillips, P. Goulder, 1998, Current Biology.

Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin

S. Hutchinson, A. Sewell, J. Boulter, 2004 .

CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract

D. Price, A. Haase, D. Douek, 2004, The Journal of experimental medicine.

Variable fate of virus‐specific CD4+ T cells during primary HIV‐1 infection

P. Easterbrook, A. Oxenius, S. J. Dawson, 2001 .

Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2

V. Appay, Sian Llewellyn-Lacey, R. Gavioli, 2023, Vaccines.

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation.

R. Koup, D. Douek, J. Brenchley, 2003, Journal of immunological methods.

CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation.

B. Autran, V. Appay, D. Douek, 2013, Clinical immunology.

of in natural infection.

N. Gormley, E. Murphy, K. Ladell, 2022 .

Cytotoxic T Lymphocyte Responses to Human Immunodeficiency Virus: Control and Escape

A. Oxenius, R. Phillips, A. Sewell, 2000, Stem cells.

Altered basal lipid metabolism underlies the functional impairment of naive CD8+ T cells in elderly humans

V. Appay, L. Papagno, E. Gostick, 2020, bioRxiv.

CD8+ T cell efficacy in vaccination and disease

V. Appay, D. Douek, D. Price, 2008, Nature Medicine.

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

D. Chudakov, K. Ladell, J. McLaren, 2017, Nature Communications.

Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux

V. Appay, K. Ladell, B. Asquith, 2016, Cell reports.

A human memory T-cell subset with stem cell-like properties

F. Marincola, D. Price, D. Douek, 2011, Nature Medicine.

Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects.

J. Melenhorst, H. Heslop, C. Rooney, 2010, Blood.

NKT and MAIT invariant TCRα sequences can be produced efficiently by VJ gene recombination.

Benedict Ng, Daniel C Douek, D. Douek, 2013, Immunobiology.

Bias in the αβ T‐cell repertoire: implications for disease pathogenesis and vaccination

Daniel C Douek, D. Douek, John J Miles, 2011, Immunology and cell biology.

Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling.

Kylie M. Quinn, A. Folgori, R. Cortese, 2015, The Journal of clinical investigation.

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

R. Koup, D. Douek, J. Brenchley, 2006, The Journal of experimental medicine.

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

M. Lederman, Jeffrey N. Martin, L. Picker, 2006, Nature Medicine.

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Morten Nielsen, David A. Price, Annika Olsson, 2020, Cell.

In vitro Induction of Myeloid Leukemia–Specific CD4 and CD8 T Cells by CD40 Ligand – Activated B Cells Gene Modified to Express Primary Granule Proteins

D. Douek, K. Rezvani, S. Kajigaya, 2005, Clinical Cancer Research.

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

G. Freeman, E. Wherry, E. Gostick, 2009, PLoS pathogens.

Identification and In Vitro Expansion of Functional Antigen-Specific CD25+ FoxP3+ Regulatory T Cells in Hepatitis C Virus Infection

B. Levine, E. Gostick, H. Ebinuma, 2008, Journal of Virology.

Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization.

G. Freeman, E. Wherry, E. Gostick, 2008, Gastroenterology.

The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection

P. Klenerman, R. Phillips, A. Sewell, 1998, Journal of Molecular Medicine.

Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

David A. Price, Brigitte Autran, Assia Samri, 2007, The Journal of experimental medicine.

Memory CD4+ T cells are generated in the human fetal intestine

Evgeny S. Egorov, O. Britanova, D. Chudakov, 2018, Nature Immunology.

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

C. Wijmenga, J. Rossjohn, K. Ladell, 2019, Cell.

Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity.

J. Melenhorst, E. Gostick, H. Shiku, 2012, Blood.

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

E. Bonifacio, S. Buus, R. Scharfmann, 2018, Science Immunology.

High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model1

A. Herlihy, D. Hafler, V. Kuchroo, 2005, The Journal of Immunology.

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

A. N. Davydov, Shannon K. Boi, C. Peano, 2020, Nature Immunology.

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

A. N. Davydov, Shannon K. Boi, C. Peano, 2020, Nature immunology.

Type I IFN Induced by Adenovirus Serotypes 28 and 35 Has Multiple Effects on T Cell Immunogenicity

R. Koup, E. Gostick, R. Sékaly, 2012, The Journal of Immunology.

Immunogenicity28 and 35 Has Multiple Effects on T Cell Type I IFN Induced by Adenovirus Serotypes

R. Koup, E. Gostick, R. Sékaly, 2012 .

Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide–MHC Class II Multimers

A. Sewell, K. Ladell, G. Dolton, 2015, The Journal of Immunology.

MHC Class II Multimers - Residue Peptide T Cells Using Altered Peptide Flanking +Detection of Antigen-Specific CD4

A. Sewell, G. Dolton, A. Godkin, 2015 .

Identification and In Vitro Expansion of Functional Antigen-Specific CD25+ FoxP3+ Regulatory T Cells in Hepatitis C Virus Infection

B. Levine, E. Gostick, H. Ebinuma, 2008, Journal of Virology.

Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation

R. Koup, D. Douek, J. Brenchley, 2006, The Journal of experimental medicine.

Preferential Infection Shortens the Life Span of Human ImmunodeficiencyVirus-Specific CD4+ T Cells In Vivo

R. Koup, D. Douek, J. Brenchley, 2006, Journal of Virology.

Preferential Infection Shortens the Life Span of Human Immunodeﬁciency Virus-Speciﬁc CD4 (cid:1) T Cells In Vivo

R. Koup, D. Douek, J. Brenchley, 2006 .

Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

A. Sewell, John J Miles, K. Ladell, 2014, Clinical and experimental immunology.

Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection

D. Price, A. Sewell, Katherine Wynn, 2012, Nature Communications.

Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

A. N. Davydov, O. Britanova, D. Chudakov, 2020, eLife.

Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation

H. Einsele, S. Mustjoki, K. Ladell, 2011, Leukemia.

Profound Inhibition of Antigen-Specific T-Cell Effector Functions by Dasatinib

H. Einsele, A. Sewell, E. Gostick, 2008, Clinical Cancer Research.

Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner.

D. Douek, M. K. Magnússon, A. Wiestner, 2005, Blood.

Structural basis of human β-cell killing by CD8+ T cells in Type 1 diabetes

J. Drijfhout, A. Sewell, B. Jakobsen, 2011, Nature Immunology.

Structural basis for the killing of human beta cells by CD 8 + T cells in type 1 diabetes

J. Drijfhout, A. Sewell, B. Jakobsen, 2012 .

Induction and Evolution of Cytomegalovirus-Specific CD4+ T Cell Clonotypes in Rhesus Macaques1

L. Picker, D. Douek, M. Axthelm, 2008, The Journal of Immunology.

Clonotypes in Rhesus Macaques T Cell + Cytomegalovirus-Specific CD4 Induction and Evolution of

L. Picker, D. Douek, M. Axthelm, 2007 .

The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self‐reactive cytotoxic T cells

A. Sewell, L. Wooldridge, M. Clement, 2011, Journal of leukocyte biology.

The multiple roles of the CD 8 coreceptor in T cell biology : opportunities for the selective modulation of self-reactive cytotoxic T cells

A. Sewell, L. Wooldridge, M. Clement, 2011 .

Antagonism of cytotoxic T-lymphocyte activation by soluble CD8

G. Gao, J. Bell, D. Price, 1999, Nature Medicine.

Immunomodulatory effects of imatinib and second-generation tyrosine kinase inhibitors on T cells and dendritic cells: an update.

M. Purbhoo, R. Seggewiss, D. Price, 2008, Cytotherapy.

Extralymphoid CD8+ T Cells Resident in Tissue from Simian Immunodeficiency Virus SIVmac239Δnef-Vaccinated Macaques Suppress SIVmac239 Replication Ex Vivo

Melisa L. Budde, Jennifer J. Lhost, K. Broman, 2010, Journal of Virology.

Extralymphoid CD8 (cid:1) T Cells Resident in Tissue from Simian Immunodeﬁciency Virus SIVmac239 (cid:2) nef-Vaccinated Macaques Suppress SIVmac239 Replication Ex Vivo (cid:1)

Melisa L. Budde, Jennifer J. Lhost, K. Broman, 2010 .

Quantification of HTLV-1 Clonality and TCR Diversity

Daniel J. Laydon, Anat Melamed, Aaron Sim, 2014, PLoS Comput. Biol..

The molecular basis for public T-cell responses?

D. Price, D. Douek, M. Davenport, 2008, Nature Reviews Immunology.

Design of Soluble Recombinant T Cell Receptors for Antigen Targeting and T Cell Inhibition*

Yi Li, Andrew K. Sewell, Daniel C. Douek, 2005, Journal of Biological Chemistry.

Dendritic Cells Promote the Spread of Human T-Cell Leukemia Virus Type 1 via Bidirectional Interactions with CD4+ T Cells.

K. Ladell, Fabien P. Blanchet, V. Piguet, 2019, The Journal of investigative dermatology.

Processing of HIV-1 Nef Mutations Disrupt Proteasomal T Cell Epitope-Flanking + CD8

P. Easterbrook, R. Phillips, A. Sewell, 2010 .

CD8+ T Cell Epitope-Flanking Mutations Disrupt Proteasomal Processing of HIV-1 Nef1

P. Easterbrook, R. Phillips, A. Sewell, 2005, The Journal of Immunology.

NefDisrupt Proteasomal Processing of HIV-1 T Cell Epitope-Flanking Mutations + CD 8 Cerundolo and

P. Easterbrook, R. Phillips, A. Sewell, 2005 .

The Identity of Human Tissue-Emigrant CD8+ T Cells

E. Wherry, A. Bar-Or, L. Picker, 2020, Cell.

TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells

C. Brander, M. Betts, E. Gostick, 2020, Science Immunology.

SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.

R. Koup, D. Douek, D. Ambrozak, 2007, Blood.

Progression of carcinogen‐induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cells via blood vessels and lymphatics

Katherine K. Matthews, K. Ladell, D. Jackson, 2013, International journal of cancer.

Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors.

K. Ladell, J. Dyson, Y. Singh, 2011, Cancer research.

Holoendemic Malaria Exposure Is Associated with Altered Epstein-Barr Virus-Specific CD8+ T-Cell Differentiation

J. Vulule, P. Chattopadhyay, M. Roederer, 2012, Journal of Virology.

Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity

S. Choo, S. Holland, S. Tangye, 2019, The Journal of allergy and clinical immunology.

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B

T. Beddoe, J. Rossjohn, S. Gras, 2011, Nature.

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

Andrew K. Sewell, Paul G. Thomas, Dmitry Chudakov, 2017, Nucleic Acids Res..

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

Sri H. Ramarathinam, Anthony W Purcell, Bosco K. Ho, 2017, Nature Structural &Molecular Biology.

CD8+ T Cells from SIV Elite Controller Macaques Recognize Mamu-B*08-Bound Epitopes and Select for Widespread Viral Variation

A. Hughes, J. Sidney, A. Sette, 2007, PloS one.

Determinants of Gliadin-Specific T Cell Selection in Celiac Disease

C. Mulder, J. van Bergen, F. Koning, 2015, The Journal of Immunology.

Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1

J. Rossjohn, E. Gostick, J. Vivian, 2015, Journal of Virology.

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections.

D. Douek, J. Brenchley, A. Khoruts, 2008, Blood.

A Recombinant Modified Vaccinia Ankara Vaccine Encoding Epstein–Barr Virus (EBV) Target Antigens: A Phase I Trial in UK Patients with EBV-Positive Cancer

D. Price, K. Harrington, K. Ladell, 2014, Clinical Cancer Research.

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.

J. Trowsdale, H. Ljunggren, C. Retière, 2013, Blood.

Interaction between the CD8 Coreceptor and Major Histocompatibility Complex Class I Stabilizes T Cell Receptor-Antigen Complexes at the Cell Surface*

Andrew K. Sewell, Meir Glick, Daniel C. Douek, 2005, Journal of Biological Chemistry.

Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes.

P. Easterbrook, A. Oxenius, R. Phillips, 2000, Proceedings of the National Academy of Sciences of the United States of America.

HIV disease: fallout from a mucosal catastrophe?

D. Douek, J. Brenchley, D. Price, 2006, Nature Immunology.

Lrp1 is a host entry factor for Rift Valley fever virus

John G Doench, J. Doench, M. Gross, 2021, Cell.

Comparative Analysis of the Magnitude, Quality, Phenotype, and Protective Capacity of Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells following Human-, Simian-, and Chimpanzee-Derived Recombinant Adenoviral Vector Immunization

Kylie M. Quinn, B. Moss, A. Folgori, 2013, The Journal of Immunology.

Immunization Recombinant Adenoviral Vector Human-, Simian-, and Chimpanzee-derived T Cells following + Gag-specific Cd8 of Simian Immunodeficiency Virus Quality, Phenotype, and Protective Capacity Comparative Analysis of the Magnitude

A. Folgori, R. Koup, M. Roederer, 2022 .

Immunisation with BCG and recombinant MVA85A induces long‐lasting, polyfunctional Mycobacterium tuberculosis‐specific CD4+ memory T lymphocyte populations

R. Koup, D. Douek, D. Ambrozak, 2007, European journal of immunology.

A T Cell Receptor Locus Harbors a Malaria‐Specific Immune Response Gene

J. Rossjohn, S. Gras, K. Ladell, 2017, Immunity.

T-Cell Subsets That Harbor Human Immunodeficiency Virus (HIV) In Vivo: Implications for HIV Pathogenesis

Mario Roederer, Daniel C. Douek, David A. Price, 2004, Journal of Virology.

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

M. Eberl, C. Fielding, R. Stanton, 2022, eLife.

ADNKA overcomes SARS-CoV2-mediated NK cell inhibition through non-spike antibodies

M. Eberl, K. Ladell, C. Graham, 2021, bioRxiv.

Identifying a Minor Histocompatibility Antigen in Mauritian Cynomolgus Macaques Encoded by APOBEC3C

Sian Llewellyn-Lacey, R. Wiseman, A. Ericsen, 2020, Frontiers in Immunology.

The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements.

D. Douek, B. Hill, K. Keyvanfar, 2007, Journal of immunological methods.

CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions

A. Sewell, A. Milicic, Bruno Laugel, 2007, European journal of immunology.

Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation.

D. Douek, J. Brenchley, K. Rezvani, 2003, Blood.

CD4+ T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4+ Cells

A. N. Davydov, A. McMichael, P. Borrow, 2020, Cell reports.

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions

S. Mustjoki, J. Melenhorst, A. Barrett, 2018, Scientific Reports.

Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

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E. Gostick, H. Blum, H. Bruns, 2014, Hepatology.

The impact of HLA class I and EBV latency‐II antigen‐specific CD8+ T cells on the pathogenesis of EBV+ Hodgkin lymphoma

M. Roederer, R. Brennan, S. Burrows, 2015, Clinical and experimental immunology.

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells

John J Miles, K. Ladell, Sian Llewellyn-Lacey, 2020, Clinical & translational immunology.

Altered basal lipid metabolism underlies the functional impairment 1 of naive CD8 + T cells in elderly humans

V. Appay, L. Papagno, E. Gostick, 2021 .

Naïve CD8+ T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8+ T-Cells

V. Appay, L. Papagno, E. Gostick, 2018, Front. Immunol..

Use of a Novel Peptide Welding Technology Platform for the Development of B- and T-Cell Epitope-Based Vaccines

V. Appay, Sian Llewellyn-Lacey, R. Gavioli, 2021, Vaccines.

Modification of MHC Anchor Residues Generates Heteroclitic Peptides That Alter TCR Binding and T Cell Recognition

Kristin Ladell, Mark Peakman, A. Sewell, 2010, The Journal of Immunology.

Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue

E. Wherry, D. Douek, M. Betts, 2018, Science Immunology.

Unbiased Molecular Analysis of T Cell Receptor Expression Using Template‐Switch Anchored RT‐PCR

D. Douek, Maire F. Quigley, J. Almeida, 2011, Current protocols in immunology.

Neonatal CD8 T-cell Hierarchy Is Distinct from Adults and Is Influenced by Intrinsic T cell Properties in Respiratory Syncytial Virus Infected Mice

P. Dash, P. Thomas, E. Gostick, 2011, PLoS pathogens.

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms’ tumor 1 antigen-targeted dendritic cell vaccination

H. Goossens, K. Ladell, E. Gostick, 2010, Proceedings of the National Academy of Sciences.

The peripheral differentiation of human natural killer T cells

D. Douek, B. Hill, M. Davenport, 2019, Immunology and cell biology.

Techniques to improve the direct ex vivo detection of low frequency antigen‐specific CD8+ T cells with peptide‐major histocompatibility complex class I tetramers

Mario Roederer, Kristin Ladell, P. Chattopadhyay, 2008, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes

L. Wen, F. Wong, D. Farewell, 2018, Diabetologia.

Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes

L. Wen, F. Wong, D. Farewell, 2018, Diabetologia.

OMIP‐002: Phenotypic analysis of specific human CD8+ T‐cells using peptide‐MHC class I multimers for any of four epitopes

P. Chattopadhyay, M. Roederer, D. Price, 2010, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Recognition of nonpeptide antigens by human V gamma 9V delta 2 T cells requires contact with cells of human origin.

S. Hutchinson, A. Sewell, J. Boulter, 2004, Clinical and experimental immunology.

Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection.

R. Haubrich, R. Koup, D. Douek, 2011, Blood.

IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine

R. Stanton, K. Ladell, E. Gostick, 2019, The Journal of Immunology.

Monoclonal TCR-redirected tumor cell killing

Yvonne McGrath, Yi Li, Bent K Jakobsen, 2012, Nature Medicine.

Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1

K. Ladell, G. Dolton, J. Hindley, 2016, Immunology and cell biology.

The CD8 T Cell Coreceptor Exhibits Disproportionate Biological Activity at Extremely Low Binding Affinities*

Andrew K. Sewell, Meir Glick, David A. Price, 2003, Journal of Biological Chemistry.

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

K. Ladell, G. Dolton, M. Kashiwagi, 2019, Scientific Reports.

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

Hideaki, Nagase, K. Ladell, 2019, Scientific Reports.

Identification of a lymphocyte minor histocompatibility antigen in Mauritian cynomolgus macaques

Sian Llewellyn-Lacey, R. Wiseman, A. Ericsen, 2020, bioRxiv.

CD4+ T follicular helper (Tfh) cells in human tonsil and blood are clonally convergent, but divergent from non-Tfh CD4+ cells. Brenna et al.

A. N. Davydov, A. McMichael, P. Borrow, 2019 .

Exploring the pre-immune landscape of antigen-specific T cells

Mikhail Shugay, Anna E. Koneva, Kristin Ladell, 2018, Genome Medicine.

Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses

S. Migueles, D. Price, M. Connors, 2005, The Journal of experimental medicine.

T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion.

K. Ladell, A. Godkin, J. Hindley, 2012, Cancer research.

Isolation of viable antigen-specific CD8+ T cells based on membrane-bound tumor necrosis factor (TNF)-α expression.

D. Douek, M. Betts, D. Ambrozak, 2011, Journal of immunological methods.

CD8 Controls T Cell Cross-Reactivity

A. Sewell, L. Wooldridge, H. A. van den Berg, 2010, The Journal of Immunology.

The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor.

D. Price, L. Picker, D. Douek, 2009, Blood.

Allogeneic HLA-A*02–Restricted WT1-Specific T Cells from Mismatched Donors Are Highly Reactive but Show Off-Target Promiscuity

J. Melenhorst, A. Barrett, R. Hagedoorn, 2011, The Journal of Immunology.

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

David T. Jones, Katherine K. Matthews, B. Chain, 2019, Nature Communications.

Identi fi cation of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors

A. Sewell, M. Roederer, John J Miles, 2016 .

Human TCR-Binding Affinity is Governed by MHC Class Restriction1

Andrew K. Sewell, George F. Gao, David A. Price, 2007, The Journal of Immunology.

Direct ex vivo analysis reveals distinct phenotypic patterns of HIV‐specific CD8+ T lymphocyte activation in response to therapeutic manipulation of virus load

H. Günthard, P. Easterbrook, J. Bell, 2001, European journal of immunology.

TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV.

D. Douek, M. Davenport, P. Scheinberg, 2008, Journal of immunology.

Memory Inflation Drives Tissue-Resident Memory CD8+ T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus

B. Graham, Syed M. Moin, A. Redwood, 2018, Front. Immunol..

Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

P. Klenerman, S. Buus, P. Goulder, 2014, AIDS.

Differential processing of HLA A2-restricted HIV type 1 cytotoxic T lymphocyte epitopes.

R. Phillips, A. Sewell, V. Cerundolo, 2002, Viral immunology.

IFN-γ Exposes a Cryptic Cytotoxic T Lymphocyte Epitope in HIV-1 Reverse Transcriptase

J. Trowsdale, R. Phillips, A. Sewell, 1999, The Journal of Immunology.

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers

A. Sewell, J. Melenhorst, K. Ladell, 2009, Journal of immunological methods.

Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-Induced Decrease in Virus Level in Simian Immunodeficiency Virusmac251-Infected Macaques1

R. Koup, D. Douek, D. Venzon, 2007, The Journal of Immunology.

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity

K. Ladell, L. Wooldridge, H. A. van den Berg, 2012, European journal of immunology.

Tetramer Enrichment Reveals the Presence of Phenotypically Diverse Hepatitis C Virus-Specific CD8+ T Cells in Chronic Infection

E. Gostick, H. Blum, R. Thimme, 2014, Journal of Virology.

Priming of qualitatively superior human effector CD 8 + T cells using TLR 8 ligand combined with FLT 3 L 1

V. Appay, E. Gostick, R. Mallone, 2017 .

Priming of Qualitatively Superior Human Effector CD8+ T Cells Using TLR8 Ligand Combined with FLT3 Ligand

V. Appay, E. Gostick, R. Mallone, 2016, The Journal of Immunology.

engagement Peptide length determines the outcome of TCR/peptide-MHCI

A. Sewell, J. Rossjohn, John J Miles, 2013 .

Peptide length determines the outcome of T cell receptor / peptide-MHCI

A. Sewell, J. Rossjohn, John J Miles, 2012 .

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

S. Burrows, K. Ladell, E. Gostick, 2016, Immunology and cell biology.

T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy.

D. Douek, J. Brenchley, N. Young, 2011, Blood.

Epitope Specificity Delimits the Functional Capabilities of Vaccine-Induced CD8 T Cell Populations

Kylie M. Quinn, D. Douek, D. Ambrozak, 2014, The Journal of Immunology.

Dendritic cells and transmission of HIV-1.

A. Sewell, D. Price, 2001, Trends in immunology.

HIV-Specific CD8+ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue

R. Koup, M. Betts, G. Reyes-Terán, 2017, Cell reports.

Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: implications for graft engineering.

D. Douek, D. Ambrozak, P. Scheinberg, 2006, Experimental hematology.

Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia[S]

K. Ladell, I. Guschina, G. Willis, 2014, Journal of Lipid Research.

lentiviral infections Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic

D. Douek, J. Brenchley, A. Khoruts, 2013 .

Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA.

K. Ladell, P. Goepfert, A. Nyakeriga, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

The STING ligand cGAMP potentiates the efficacy of vaccine-induced CD8+ T cells.

V. Appay, L. Papagno, E. Gostick, 2019, JCI insight.

This information is current as Sharing in Murine Thymocytes β TCR Recombination Determine Interindividual Recombinatorial Biases and Convergent

Guoli Ji, Congting Ye, Daniel C. Douek, 2012 .

Cytotoxic T lymphocytes, chemokines and antiviral immunity.

P. Klenerman, R. Phillips, A. Sewell, 1999, Immunology today.

Immortalization and Functional Screening of Natively Paired Human T Cell Receptor Repertoires

D. Douek, H. Balfour, Sian Llewellyn-Lacey, 2021, bioRxiv.

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells

K. Ladell, J. McLaren, E. James, 2019, The Journal of Immunology.

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways

M. Weekes, P. Tomasec, C. Fielding, 2023, bioRxiv.

Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1

D. Koning, B. Grady, D. van Baarle, 2014, Journal of Virology.

Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection

Sagar, C. Conrad, R. Eils, 2021, Nature Immunology.

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region

M. Glick, S. Hutchinson, A. Sewell, 2007, European journal of immunology.

Convergent recombination shapes the clonotypic landscape of the naïve T-cell repertoire

Daniel C. Douek, David A. Price, Miles P. Davenport, 2010, Proceedings of the National Academy of Sciences.

Regulatory T-cell depletion does not prevent emergence of new CD25+ FOXP3+ lymphocytes after antigen stimulation in culture.

D. Douek, D. Ambrozak, J. Melenhorst, 2008, Cytotherapy.

Preexisting memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial

B. Haynes, W. Fischer, N. Frahm, 2021, The Journal of clinical investigation.

Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus

M. Weekes, R. Stanton, E. Wang, 2021, The Journal of clinical investigation.

Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Sian Llewellyn-Lacey, Y. Ni, S. Urban, 2019, Gut.

Immune Characteristics Associated with Lymphomatoid Granulomatosis and Outcome Following Treatment with Interferon-Alpha

W. Wilson, E. Jaffe, S. Pittaluga, 2010 .

Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8+ T Cells in HIV Infection1

R. Koup, D. Douek, D. Ambrozak, 2009, The Journal of Immunology.

T Cells in HIV Infection + CD 8 Death-1 and CD 57 with Ex Vivo Survival of Differential Association of Programmed

R. Koup, D. Douek, D. Ambrozak, 2009 .

Reduced na € ıve CD8 + T-cell priming efﬁcacy in elderly adults

K. Stiasny, V. Appay, L. Papagno, 2016 .

A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults

A. Winston, R. Koup, D. Douek, 2011, BMJ Open.

Therapeutic vaccination expands and improves the function of the HIV-specific memory T-cell repertoire.

R. Gottardo, R. Koup, C. Andrews, 2013, The Journal of infectious diseases.

Critical Role of TLR7 Signaling in the Priming of Cross-Protective Cytotoxic T Lymphocyte Responses by a Whole Inactivated Influenza Virus Vaccine

L. Boon, E. Gostick, J. Wilschut, 2013, PloS one.

Virus-Specific CD8+ TCRs between Sharing of Simian Immunodeficiency The Role of Production Frequency in the

V. Venturi, H. Y. Chin, D. Price, 2013 .

The Role of Production Frequency in the Sharing of Simian Immunodeficiency Virus-Specific CD8+ TCRs between Macaques1

Daniel C. Douek, David A. Price, Miles P. Davenport, 2008, The Journal of Immunology.

Macaques TCRs between + Virus-Specific CD 8 Sharing of Simian Immunodeficiency The Role of Production Frequency in the Douek and

D. Douek, M. Davenport, V. Venturi, 2008 .

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

K. Hokamp, F. Roche, P. Dash, 2020, The Journal of experimental medicine.

Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood.

D. Douek, D. Cooper, M. Davenport, 2007, Journal of immunological methods.

Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection

Sagar, C. Conrad, R. Bartenschlager, 2021, Nature Immunology.

CD8+ T cell‐mediated suppression of intracellular Mycobacterium tuberculosis growth in activated human macrophages

H. McShane, A. Hill, R. Brookes, 2003, European journal of immunology.

Virus Inhibition Activity of Effector Memory CD8+ T Cells Determines Simian Immunodeficiency Virus Load in Vaccinated Monkeys after Vaccine Breakthrough Infection

R. Koup, D. Douek, N. Letvin, 2012, Journal of Virology.

The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells

K. Ladell, Sian Llewellyn-Lacey, J. McLaren, 2023, Communications Biology.

Human T cell dynamics in vivo are compatible with long-lived immunological memory and stemness

D. Speiser, K. Ladell, B. Asquith, 2018 .

Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers.

D. Douek, P. Chattopadhyay, A. Sewell, 2008, Journal of immunological methods.

Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8+ T Cells in Elderly Humans

V. Appay, L. Papagno, E. Gostick, 2022, The Journal of Immunology.

Clonal selection in the human V delta 1 T cell repertoire indicates gamma delta TCR-dependent adaptive immune surveillance

D. Chudakov, K. Ladell, J. McLaren, 2017 .

Antigenic Complex Primarily by the Peptide Component of the TCR Repertoire Formation Is Guided + CD8

Katherine K. Matthews, I. Hoof, John J Miles, 2013 .

The molecular determinants of CD8 co‐receptor function

A. Sewell, L. Wooldridge, M. Clement, 2012, Immunology.

Selection in Celiac Disease Determinants of Gliadin-Specific T Cell

C. Mulder, F. Koning, J. Rossjohn, 2015 .

Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells

K. Ladell, L. Wooldridge, Sian Llewellyn-Lacey, 2021, The Journal of Immunology.

Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers.

E. Wherry, M. Betts, E. Gostick, 2015, The Journal of infectious diseases.

Virological and immunological effects of short-course antiretroviral therapy in primary HIV infection

A. Oxenius, R. Phillips, J. Weber, 2002, AIDS.

Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation

G. Ogg, K. Ladell, H. Koohy, 2023, Science Immunology.

High avidity myeloid leukemia-associated antigen-speciﬁc CD8 (cid:1) T cells preferentially reside in the bone marrow

D. Douek, P. Chattopadhyay, M. Roederer, 2009 .

preferentially reside in the bone marrow

D. Douek, P. Chattopadhyay, M. Roederer, 2008 .

Variable fate of virus-specific CD4(+) T cells during primary HIV-1 infection.

P. Easterbrook, A. Oxenius, S. J. Dawson, 2001, European journal of immunology.

Mechanisms of CD8+ T cell failure in chronic hepatitis E virus infection.

Sian Llewellyn-Lacey, K. Warnatz, R. Thimme, 2022, Journal of hepatology.

Breakthrough Infection Vaccinated Monkeys after Vaccine Immunodeficiency Virus Load in T Cells Determines Simian + CD8Virus Inhibition Activity of Effector Memory

R. Koup, D. Douek, N. Letvin, 2023 .

Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection

V. Appay, L. Papagno, Sian Llewellyn-Lacey, 2023, EBioMedicine.

Functional Discrepancies in HIV-Specific CD8+ T-Lymphocyte Populations Are Related to Plasma Virus Load

S. Rowland-Jones, H. Günthard, C. Fagard, 2002, Journal of Clinical Immunology.

Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4+ and CD8+ memory formation

E. Gostick, H. Abken, M. Assenmacher, 2015, Immunology.

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

K. Ladell, G. Dolton, M. Kashiwagi, 2019, Scientific Reports.

Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Thomas S. Watkins, Katherine K. Matthews, A. Sewell, 2015, Immunology and cell biology.

Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox

A. Sette, H. Ljunggren, Sian Llewellyn-Lacey, 2023, Cell host & microbe.

Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles.

K. Ladell, A. Clayton, I. Guschina, 2014, Human reproduction.

SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues.

D. Douek, J. Brenchley, S. Darko, 2020, The Journal of clinical investigation.

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

Katherine K. Matthews, P. Bingley, S. Heck, 2014, Diabetes.

Estimation of clonal diversity in HTLV-1 infection

D. Laydon, D. Douek, S. Darko, 2014, Retrovirology.

Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease

Jeff E. Mold, J. McCune, K. Ladell, 2015, The Journal of Immunology.

The pentameric complex drives immunologically covert cell–cell transmission of wild-type human cytomegalovirus

P. Tomasec, R. Stanton, I. Murrell, 2017, Proceedings of the National Academy of Sciences.

On the path to TCR-directed therapeutics

A. Sewell, Bruno Laugel, D. Price, 2006, Nature Biotechnology.

Human circulating and tissue-resident memory CD8+ T cells

M. Betts, M. Buggert, Laura K. Mackay, 2023, Nature Immunology.

High Production Rates Sustain In Vivo Levels of PD-1high Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance

Z. Grossman, M. Meier-Schellersheim, R. Koup, 2013, Journal of Virology.

Anti-CD8 Antibodies Can Trigger CD8+ T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide–MHCI Tetramer Staining

A. Sewell, John J Miles, S. Burrows, 2011, The Journal of Immunology.

CD4+ T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity.

K. Ladell, J. Petersen, Martijn D. B. van de Garde, 2023, Immunity.

Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion

J. Hasenauer, M. Hoelscher, R. Rubio-Acero, 2023, Nature communications.

Clonotype and Repertoire Changes Drive the Functional Improvement of HIV-Specific CD8 T Cell Populations under Conditions of Limited Antigenic Stimulation

D. Price, R. Koup, D. Douek, 2012, The Journal of Immunology.

Stochastic Expansions Maintain the Clonal Stability of CD8+ T Cell Populations Undergoing Memory Inflation Driven by Murine Cytomegalovirus

Thurston H. Y. Dang, Kylie M. Quinn, D. Douek, 2019, The Journal of Immunology.

Intrathecal T‐cell clonal expansions in patients with multiple sclerosis

D. Douek, S. Darko, R. Nicholas, 2016, Annals of clinical and translational neurology.

Different Vaccine Vectors Delivering the Same Antigen Elicit CD8+ T Cell Responses with Distinct Clonotype and Epitope Specificity1

D. Douek, D. Margulies, G. Nabel, 2009, The Journal of Immunology.

This information is current as Specificity with Distinct Clonotype and Epitope T Cell Responses + Same Antigen Elicit CD 8 Different Vaccine Vectors Delivering the

D. Douek, D. Margulies, G. Nabel, 2009 .

Cell activation-based screening of natively paired human T cell receptor repertoires

R. Koup, H. Balfour, Sian Llewellyn-Lacey, 2023, Scientific reports.

GERMLINE-GOVERNED RECOGNITION OF A CANCER EPITOPE BY AN IMMUNODOMINANT HUMAN T-CELL RECEPTOR

G. Gao, A. Sewell, B. Jakobsen, 2009 .

Abstract 3525: IMCgp100: A novel bi-specific biologic for the treatment of malignant melanoma

G. Linette, M. Kalos, C. June, 2012 .

In Vitro Induction of Myeloid Leukemia Specific CD4 and CD8 T-Cells by CD40 Ligand Activated B Cells Gene-Modified to Express Primary Granule Proteins.

D. Douek, K. Rezvani, S. Kajigaya, 2004 .

Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype

F. Wong, K. Ladell, C. Dayan, 2020, Diabetologia.

HIV-Specific CD 8 + T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue Graphical

R. Koup, M. Betts, G. Reyes-Terán, 2017 .

Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor

A. Oxenius, S. Hutchinson, A. Sewell, 2007, European journal of immunology.

Rituximab depletion of intrahepatic B cells to control refractory hepatic autoimmune overlap syndrome

K. Ladell, A. Godkin, A. Gallimore, 2019, QJM : monthly journal of the Association of Physicians.

Novel CD8+ T Cell Antagonists Based on β2-Microglobulin*

Andrew K. Sewell, Meir Glick, Bent K. Jakobsen, 2002, The Journal of Biological Chemistry.

An inter-species difference in the CD8 coreceptor

A. Sewell, D. Price, 2001 .

Myelodysplasia with Trisomy 8 Is Associated with a Cytotoxic CD8 T Cell Immune Response to Wilms Tumor-1 Protein (WT1).

D. Douek, K. Rezvani, N. Young, 2004 .

Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes.

A. Oxenius, D. Price, R. Phillips, 2001, AIDS research and human retroviruses.

University of Groningen Critical Role of TLR7 Signaling in the Priming of Cross-Protective Cytotoxic T Lymphocyte Responses by a Whole Inactivated Influenza Virus Vaccine Budimir,

L. Boon, E. Gostick, J. Wilschut, 2013 .

Curtailed T‐cell activation curbs effector differentiation and generates CD8+ T cells with a naturally‐occurring memory stem cell phenotype

P. Romero, K. Pilipow, E. Lugli, 2017, European Journal of Immunology.

A Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1

M. Swartz, F. Nestle, A. Sewell, 2016 .

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

T. Ndung’u, M. Nielsen, W. Bishai, 2019, Communications Biology.

2019-0605 TRAV 1-2 ( + ) CD 8 ( + ) T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

M. Nielsen, W. Bishai, U. Lalloo, 2019 .

High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs

R. Sessions, M. Heemskerk, K. Ladell, 2023, The Journal of biological chemistry.

Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Sian Llewellyn-Lacey, A. Schmitt-Graeff, R. Thimme, 2019, Oncotarget.

Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors

K. Ladell, S. Anderton, R. O’Connor, 2015, Oncotarget.

Cutting Edge: A Dual TLR2 and TLR7 Ligand Induces Highly Potent Humoral and Cell-Mediated Immune Responses

V. Appay, L. Papagno, E. Gostick, 2017, The Journal of Immunology.

The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8+ T-cell responses in vitro

V. Appay, L. Papagno, E. Gostick, 2020, Scientific Reports.

Dyslipidemia due to retroviral protease inhibitors

A. Sewell, A. Kelleher, D. Price, 2002, Nature Medicine.

Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8+ T cells

J. Aerssens, Sian Llewellyn-Lacey, P. Knolle, 2023, Gut.

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

T. Ndung’u, M. Nielsen, W. Bishai, 2019, Communications Biology.

Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens.

P. Easterbrook, A. Oxenius, S. J. Dawson, 2001, AIDS.

CD8 + T-cell speci ﬁ city is compromised at a de ﬁ ned MHCI/CD8 af ﬁ nity threshold

S. Burrows, K. Ladell, E. Gostick, 2023 .

Acute-Phase CD8 T Cell Responses That Select for Escape Variants Are Needed to Control Live Attenuated Simian Immunodeficiency Virus

K. Broman, T. Friedrich, E. Gostick, 2013, Journal of Virology.

Infected Macaquesmac 251 Level in Simian Immunodeficiency Virus VirusAbrogates Vaccine-Induced Decrease in Interleukin-15 but Not Interleukin-7

R. Koup, D. Douek, D. Venzon, 2007 .

This information is current as HLA and Peptide Sensitivity Allotypic Dimorphism That Impacts Both KIR 3 DL 1 Reveals a Lineage-Defining Mutational and Structural Analysis of

J. Rossjohn, E. Gostick, S. Anderson, 2014 .

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor

A. Sewell, K. Ladell, L. Wooldridge, 2020, Proceedings of the National Academy of Sciences.

Effector cytotoxic T lymphocyte numbers induced by vaccination should exceed levels in chronic infection for protection from HIV.

V. Jansen, H. K. Altes, D A Price, 2001, Vaccine.

Analysis of the functional WT1-speciﬁc T-cell repertoire in healthy donors reveals a discrepancy between CD4 + and CD8 + memory formation

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