A. Di Spiezio

Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis

Mahmoud A. Bassal, R. Lüllmann-Rauch, P. Saftig, 2020, Autophagy.

Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals

C. Bertozzi, P. Saftig, Monther Abu-Remaileh, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

C. Hock, P. Saftig, L. Kulic, 2023, Scientific Reports.

Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier.

T. Bayer, R. Vandenbroucke, S. Weggen, 2015, The Journal of clinical investigation.

The LepR-mediated leptin transport across brain barriers controls food reward

H. Lehnert, M. Schwaninger, H. Oster, 2017, Molecular metabolism.

Two decades of astrocytes in neurovascular coupling

M. Zonta, A. Lia, A. Di Spiezio, 2023, Frontiers in Network Physiology.

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models

S. Rose-John, P. Saftig, B. Winner, 2022, Autophagy.

Nesfatin-1 decreases the motivational and rewarding value of food

M. Passafaro, T. Horvath, M. Shanabrough, 2020, Neuropsychopharmacology.

Analysis of cathepsin B and cathepsin L treatment to clear toxic lysosomal protein aggregates in neuronal ceroid lipofuscinosis.

P. Saftig, U. Bartsch, Lisa Gallwitz, 2021, Biochimica et biophysica acta. Molecular basis of disease.