Y. Watanabe

发表

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2017, Bioorganic & medicinal chemistry letters.

Systematic preparation method of a molecular model explicitly describing electron distributions for halogen bonds

H. Gouda, Daichi Hayakawa, Y. Watanabe, 2022, Chemical Physics Letters.

Susceptibility to cytosine arabinoside (Ara-C)-induced cytotoxicity in human leukemia cell lines.

M. Ishikawa, Syu-Ichi Kanno, Ai Shouji, 2004, Toxicology letters.

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2019, Bioorganic & medicinal chemistry.

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2017, Bioorganic & medicinal chemistry letters.

In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor

I. Takasaki, H. Gouda, A. Miyata, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Evaluation of Influence of Single Nucleotide Polymorphisms in Cytochrome P450 2B6 on Substrate Recognition Using Computational Docking and Molecular Dynamics Simulation

M. Hiratsuka, N. Yamaotsu, S. Hirono, 2014, PloS one.

Predicting the structures of complexes between phosphoinositide 3-kinase (PI3K) and romidepsin-related compounds for the drug design of PI3K/histone deacetylase dual inhibitors using computational docking and the ligand-based drug design approach.

C. Ishioka, S. Fukuyoshi, O. Takahashi, 2014, Journal of molecular graphics & modelling.

Structural differences between the ligand-binding pockets of estrogen receptors alpha and beta

S. Fukuyoshi, N. Yamaotsu, A. Oda, 2018, Journal of Physics: Conference Series.

Investigation of photoreaction for 2-nitrobenzofuran and its 3-methyl derivative

S. Fukuyoshi, A. Oda, Tomohiro Tanaka, 2015 .

Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist.

I. Takasaki, K. Nunomura, H. Gouda, 2022, European journal of medicinal chemistry.

Comparison of photoreactions of flutamide in acetonitrile and 2-propanol solvents in the absence of cage-forming compounds

S. Fukuyoshi, A. Oda, Y. Watanabe, 2015 .

A docking model of dapsone bound to HLA-B*13:01 explains the risk of dapsone hypersensitivity syndrome.

T. Mushiroda, H. Gouda, Toshinori Yamamoto, 2017, Journal of dermatological science.

A molecular interaction field describing nonconventional intermolecular interactions and its application to protein-ligand interaction prediction.

Yurie Watanabe, H. Gouda, Daichi Hayakawa, 2019, Journal of molecular graphics & modelling.

Triethylated chromones with substituted naphthalenes as tubulin inhibitors.

A. Oda, K. Lee, E. Hamel, 2016, Bioorganic & medicinal chemistry.

Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase.

Kiyomi Nakagawa, M. Mizuguchi, H. Gouda, 2017, Bioorganic & medicinal chemistry letters.

Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase

Yoshiyuki Suzuki, T. Nonaka, K. Inaka, 2019, Scientific Reports.

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.

Yurie Watanabe, M. Yanagisawa, D. Kuroda, 2017, Journal of medicinal chemistry.

Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors.

H. Gouda, H. Nagase, Shigeto Hirayama, 2021, Bioorganic & medicinal chemistry.

Correction to Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.

A. Ikari, H. Gouda, K. Kuwata, 2017, Journal of medicinal chemistry.

Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.

A. Ikari, H. Gouda, K. Kuwata, 2017, Journal of medicinal chemistry.

Molecular dynamics study of the interaction between PACAP (6’–38’) and the N-terminal extracellular domain of the human splice variant hPAC1-R-short, aiming at the development of neuropathic pain medicine

A. Oda, H. Gouda, Y. Watanabe, 2018, Journal of Physics: Conference Series.

Investigation of substrate recognition for cytochrome P450 1A2 mediated by water molecules using docking and molecular dynamics simulations.

Yurie Watanabe, S. Fukuyoshi, M. Hiratsuka, 2017, Journal of molecular graphics & modelling.

Unpolarizable molecular model describing electron distribution for treating halogen bonds

H. Gouda, Daichi Hayakawa, Y. Watanabe, 2021 .

Prediction of three-dimensional structures and structural flexibilities of wild-type and mutant cytochrome P450 1A2 using molecular dynamics simulations.

Yurie Watanabe, S. Fukuyoshi, M. Hiratsuka, 2016, Journal of molecular graphics & modelling.

Design, synthesis, structure-activity relationship studies, and evaluation of novel GLS1 inhibitors.

M. Mizuguchi, K. Koizumi, H. Gouda, 2023, Bioorganic & medicinal chemistry letters.