Jonathan E. Shelton

发表

Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate.

P. Bonaventure, Kiev S. Ly, T. Lovenberg, 2015, Journal of medicinal chemistry.

Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia

P. Bonaventure, T. Lovenberg, N. Carruthers, 2015, The Journal of Pharmacology and Experimental Therapeutics.

3,5-Dihydroxybenzoic Acid, a Specific Agonist for HCA1, Inhibits Lipolysis in Adipocytes

T. Lovenberg, Jiejun Wu, M. Connelly, 2012 .

Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

P. Bonaventure, T. Lovenberg, C. Dugovic, 2014, Front. Neurosci..

Translational evaluation of JNJ-18038683, a 5-HT7 receptor antagonist, on REM sleep and in major depressive disorder

P. Bonaventure, C. Dvorak, T. Lovenberg, 2012 .

REM sleep and in major depressive disorder

P. Bonaventure, W. Chai, C. Dvorak, 2012 .

Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor.

P. Bonaventure, Sandy J. Wilson, T. Lovenberg, 2007, European journal of pharmacology.

Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects.

C. Dvorak, T. Lovenberg, N. Carruthers, 2012, ACS medicinal chemistry letters.

Probing the Functional Domains of Relaxin‐3 and the Creation of a Selective Antagonist for RXFP3/GPCR135 over Relaxin Receptor RXFP1/LGR7

P. Bonaventure, T. Lovenberg, J. Wade, 2009, Annals of the New York Academy of Sciences.

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81*

F. Kamme, T. Lovenberg, Jiejun Wu, 2009, Journal of Biological Chemistry.

Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines.

P. Bonaventure, J. A. Jablonowski, C. Dvorak, 2009, European journal of medicinal chemistry.

A Selective Orexin-1 Receptor Antagonist Attenuates Stress-Induced Hyperarousal without Hypnotic Effects

T. P. Lebold, P. Bonaventure, T. Lovenberg, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Altered sleep regulation in leptin-deficient mice.

F. Turek, J. Bass, C. Dugovic, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat

P. Bonaventure, C. Dvorak, T. Lovenberg, 2009, Journal of Pharmacology and Experimental Therapeutics.

5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor

P. Bonaventure, T. Lovenberg, C. Dugovic, 2009, Neuropharmacology.

Metabolic Syndrome Altered sleep regulation in leptin-deficient mice

F. Turek, J. Bass, C. Dugovic, 2005 .

Selective Blockade of 5-Hydroxytryptamine (5-HT)7 Receptors Enhances 5-HT Transmission, Antidepressant-Like Behavior, and Rapid Eye Movement Sleep Suppression Induced by Citalopram in Rodents

P. Bonaventure, T. Lovenberg, J. Atack, 2007, Journal of Pharmacology and Experimental Therapeutics.

R3(BΔ23–27)R/I5 Chimeric Peptide, a Selective Antagonist for GPCR135 and GPCR142 over Relaxin Receptor LGR7

P. Bonaventure, F. Kamme, T. Lovenberg, 2007, Journal of Biological Chemistry.

3,5-Dihydroxybenzoic Acid, a Specific Agonist for Hydroxycarboxylic Acid 1, Inhibits Lipolysis in Adipocytes

T. Lovenberg, N. Carruthers, Jiejun Wu, 2012, Journal of Pharmacology and Experimental Therapeutics.

Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice

P. Bonaventure, T. Lovenberg, C. Dugovic, 2017, Frontiers in Behavioral Neuroscience.

R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.

P. Bonaventure, F. Kamme, T. Lovenberg, 2007, The Journal of biological chemistry.

Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity

P. Bonaventure, C. Dvorak, T. Lovenberg, 2015, Front. Behav. Neurosci..

Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.

P. Bonaventure, Kiev S. Ly, T. Lovenberg, 2015, ACS Medicinal Chemistry Letters.

Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.

P. Bonaventure, Kiev S. Ly, T. Lovenberg, 2010, Bioorganic & medicinal chemistry letters.

Translational Evaluation of JNJ-18038683, a 5-Hydroxytryptamine Type 7 Receptor Antagonist, on Rapid Eye Movement Sleep and in Major Depressive Disorder

P. Bonaventure, C. Dvorak, T. Lovenberg, 2012, Journal of Pharmacology and Experimental Therapeutics.

1 R 3 ( B ∆ 23-27 ) R / I 5 CHIMERIC PEPTIDE , A SELECTIVE ANTAGONIST FOR GPCR 135 AND GPCR 142 OVER RELAXIN RECEPTOR LGR 7 : IN VITRO AND IN VIVO CHARACTERIZATION

P. Bonaventure, F. Kamme, Jiejun Wu, 2007 .

Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System

P. Bonaventure, T. Lovenberg, Changlu Liu, 2009, Annals of the New York Academy of Sciences.

3,5-Dihydroxybenzoic Acid, a Specific Agonist for Hydroxycarboxylic Acid 1, Inhibits Lipolysis in Adipocytes

T. Lovenberg, N. Carruthers, Jiejun Wu, 2012, Journal of Pharmacology and Experimental Therapeutics.

Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions

A. Saha, M. Seierstad, Michelle L. Wennerholm, 2024, ACS Medicinal Chemistry Letters.