G. V. van Zyl

发表

Approach to the management of paediatric HIV spontaneous controllers

S. Barnabas, A. V. van Rensburg, Peter Zuidewind, 2022, Southern African journal of infectious diseases.

Early Emergence and Long-Term Persistence of HIV-Infected T-Cell Clones in Children

S. Hughes, J. Mellors, J. Coffin, 2021, mBio.

Early Emergence and Long-Term Persistence of HIV-Infected T Cell Clones in Children

S. Hughes, J. Mellors, J. Coffin, 2020, bioRxiv.

Detection of a SARS-CoV-2 variant of concern in South Africa

Sergei L. Kosakovsky Pond, A. Godzik, A. Sigal, 2021, Nature.

HIV-1 RNA testing of pooled dried blood spots is feasible to diagnose acute HIV infection in resource limited settings

M. Cotton, W. Preiser, M. Van Schalkwyk, 2018, Southern African Journal of Infectious Diseases.

Extraction buffer contaminated bacterially as a cause of invalid HIV-1 viral load results on the NucliSens EasyQ system.

W. Preiser, M. Claassen, G. V. van Zyl, 2008, Journal of virological methods.

HIV drug resistance in various body compartments

J. Dorfman, G. V. Van Zyl, M. Kearney, 2022, Current opinion in HIV and AIDS.

An assessment of Nano-RECall: Interpretation of Oxford Nanopore sequence data for HIV-1 drug resistance testing

P. Harrigan, U. Parikh, C. Woods, 2022, bioRxiv.

Pooling strategies to reduce the cost of HIV-1 RNA load monitoring in a resource-limited setting.

R. Haubrich, D. Smith, W. Preiser, 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Comparing the findings and diagnostic sensitivity of cardiovascular magnetic resonance in biopsy confirmed acute myocarditis with infarct-like vs. heart failure presentation

A. Doubell, C. Kyriakakis, P. Robbertse, 2022, Journal of Cardiovascular Magnetic Resonance.

Irreproducible positive results on the Cobas AmpliPrep/Cobas TaqMan HIV‐1 Qual test are different qualitatively from confirmed positive results

W. Preiser, J. Maritz, G. V. van Zyl, 2013, Journal of medical virology.

HIV‐1 DNA decay is faster in children who initiate ART shortly after birth than later

J. Mellors, G. V. Van Zyl, M. Cotton, 2019, Journal of the International AIDS Society.

Sixteen novel lineages of SARS-CoV-2 in South Africa

A. Sigal, Francesco Petruccione, T. de Oliveira, 2021, Nature Medicine.

Emergence of HIV drug resistance during first- and second-line antiretroviral therapy in resource-limited settings.

J. Nachega, Ravindra K. Gupta, G. V. Van Zyl, 2013, The Journal of infectious diseases.

Low Lopinavir Plasma or Hair Concentrations Explain Second-Line Protease Inhibitor Failures in a Resource-Limited Setting

J. Nachega, G. Maartens, Yong Huang, 2011, Journal of acquired immune deficiency syndromes.

Clinical Experience With Severe Acute Respiratory Syndrome Coronavirus 2–Related Illness in Children: Hospital Experience in Cape Town, South Africa

P. Goussard, M. M. van der Zalm, H. Rabie, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

SARS-CoV-2 in children and their accompanying caregivers: Implications for testing strategies in resource limited hospitals

G. V. Van Zyl, M. M. van der Zalm, H. Rabie, 2022, African Journal of Emergency Medicine.

Detection of a SARS-CoV-2 variant of concern in South Africa

A. Godzik, A. Sigal, B. Sewell, 2021, Nature.

A genomics network established to respond rapidly to public health threats in South Africa

A. Christoffels, T. de Oliveira, J. Bhiman, 2020, The Lancet Microbe.

Zidovudine with nevirapine for the prevention of HIV mother‐to‐child transmission reduces nevirapine resistance in mothers from the Western Cape, South Africa

G. Theron, M. Cotton, W. Preiser, 2008, Journal of medical virology.

Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens

Simon A. A. Travers, Tommy F. Liu, R. Shafer, 2013, PloS one.

Deep Sequencing Reveals Minor Protease Resistance Mutations in Patients Failing a Protease Inhibitor Regimen

Simon A. A. Travers, Sergei L. Kosakovsky Pond, S. Travers, 2012, Journal of Virology.

It is time to consider third-line options in antiretroviral-experienced paediatric patients?

G. V. Van Zyl, M. Cotton, H. Rabie, 2011, Journal of the International AIDS Society.

PROTEASE INHIBITOR RESISTANCE IN SOUTH AFRICAN CHILDREN WITH VIROLOGIC FAILURE

G. V. Van Zyl, M. Cotton, W. Preiser, 2009, The Pediatric infectious disease journal.

HIV treatment adherence, drug resistance, virologic failure: Evolving concepts

J. Nachega, R. Gross, E. Mills, 2022 .

PhyloPi: An affordable, purpose built phylogenetic pipeline for the HIV drug resistance testing facility

Dominique Goedhals, Andrie De Vries, Kim Steegen, 2018, bioRxiv.

Emerging antiretroviral drug resistance in sub-Saharan Africa: novel affordable technologies are needed to provide resistance testing for individual and public health benefits.

J. Nachega, J. Mellors, G. V. Van Zyl, 2014, AIDS.

A qualitative PCR minipool strategy to screen for virologic failure and antiretroviral drug resistance in South African patients on first-line antiretroviral therapy.

G. V. Van Zyl, W. Preiser, A. Stich, 2014, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Next generation sequencing improves detection of drug resistance mutations in infants after PMTCT failure.

Sergei L. Kosakovsky Pond, R. Haubrich, Davey M. Smith, 2015, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Another milestone in minimizing risks to mothers exposed to single-dose nevirapine for prevention of vertical transmission of HIV-1 to infants: what next?

G. V. Van Zyl, M. Cotton, H. Rabie, 2010, Clinical Infectious Diseases.

Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation

Philip L. Tzou, D. Katzenstein, R. Shafer, 2017, PloS one.

Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration

Huldrych F. Günthard, Dominique Goedhals, Susan P. Holmes, 2017, EBioMedicine.

Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites

D. Haas, G. Maartens, S. Khoo, 2018, The Journal of antimicrobial chemotherapy.

Adult antiretroviral therapy guidelines 2017

Yunus Moosa, G. V. Van Zyl, M. Moorhouse, 2017, Southern African journal of HIV medicine.

New Technological Developments in Identification and Monitoring of New and Emerging Infections

G. V. Van Zyl, G. V. van Zyl, 2021, Reference Module in Biomedical Sciences.

Molecular characterisation and epidemiology of enterovirus-associated aseptic meningitis in the Western and Eastern Cape Provinces, South Africa 2018-2019.

W. Preiser, K. McCarthy, H. Smuts, 2021, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

A Clinical Prediction Rule for Protease Inhibitor Resistance in Patients Failing Second-Line Antiretroviral Therapy

A. Kengne, G. Maartens, G. Meintjes, 2019, Journal of acquired immune deficiency syndromes.

Future technologies for monitoring HIV drug resistance and cure

J. Mellors, G. V. Van Zyl, K. McCormick, 2017, Current opinion in HIV and AIDS.

Epidemiology and outcomes of SARS-CoV-2 infection associated with anti-nucleocapsid seropositivity in Cape Town, South Africa

H. Mahomed, W. Preiser, A. Redd, 2022, medRxiv.

Major new lineages of SARS-CoV-2 emerge and spread in South Africa during lockdown.

A. Sigal, T. de Oliveira, J. Bhiman, 2020, medRxiv.

Rapid replacement of the Beta variant by the Delta variant in South Africa

Wasim Abdool Karim, C. Althaus, T. de Oliveira, 2021, medRxiv.

Multiple Early Introductions of SARS-CoV-2 to Cape Town, South Africa

T. de Oliveira, W. Preiser, E. Wilkinson, 2021, Viruses.

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

T. Ndung’u, A. Sigal, B. Sewell, 2021, Nature.

HIV evolution and diversity in ART-treated patients

G. V. Van Zyl, M. Kearney, Mary F. Kearney, 2018, Retrovirology.

Assessment of HIV transfusion transmission risk in South Africa: a 10‐year analysis following implementation of individual donation nucleic acid amplification technology testing and donor demographics eligibility changes

M. Busch, A. Welte, R. Swanevelder, 2018, Transfusion.

Novel Criteria for Diagnosing Acute and Early HIV Infection in a Multi-National Study of Early Antiretroviral Therapy Initiation.

B. Chi, J. Ananworanich, K. Ruxrungtham, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

HIV incidence in South African blood donors from 2012 to 2016: a comparison of estimation methods

E. Murphy, M. Busch, D. Brambilla, 2020, Vox sanguinis.

Intact HIV Proviruses Persist in Children Seven to Nine Years after Initiation of Antiretroviral Therapy in the First Year of Life

Wei-Shau Hu, J. Mellors, Imogen A. Wright, 2019, Journal of Virology.

Early Antiretroviral Therapy in South African Children Reduces HIV-1-Infected Cells and Cell-Associated HIV-1 RNA in Blood Mononuclear Cells.

J. Mellors, G. V. Van Zyl, M. Cotton, 2015, The Journal of infectious diseases.

SURVEILLANCE OF TRANSMITTED RESISTANCE TO ANTIRETROVIRAL DRUG CLASSES AMONG YOUNG CHILDREN IN THE WESTERN CAPE PROVINCE OF SOUTH AFRICA

M. Cotton, W. Preiser, M. Claassen, 2009, The Pediatric infectious disease journal.

HIV-1 antiretroviral drug resistance patterns in patients failing NNRTI-based treatment: results from a national survey in South Africa

W. MacLeod, I. Sanne, W. Stevens, 2017, The Journal of antimicrobial chemotherapy.

HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing

T. F. Rinke de Wit, D. Katzenstein, R. Shafer, 2015, PloS one.

Nucleoside reverse transcriptase inhibitor resistance mutations associated with first-line stavudine-containing antiretroviral therapy: programmatic implications for countries phasing out stavudine.

D. Katzenstein, N. Ford, R. Shafer, 2013, The Journal of infectious diseases.

Better Virological Outcomes Among People Living With Human Immunodeficiency Virus (HIV) Initiating Early Antiretroviral Treatment (CD4 Counts ≥500 Cells/µL) in the HIV Prevention Trials Network 071 (PopART) Trial in South Africa

R. Hayes, J. Nachega, H. Ayles, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

HIV Drug Resistance (HIVDR) in Antiretroviral Therapy-Naïve Patients in Tanzania Not Eligible for WHO Threshold HIVDR Survey Is Dramatically High

G. V. Van Zyl, W. Preiser, A. Rethwilm, 2011, PloS one.

What Should We Do When HIV-positive Children Fail First-line Combination Antiretroviral Therapy ? A Comparison of 4 ART Management Strategies

M. Egger, F. Tanser, B. Eley, 2022 .

HIV-1 Persistence in Children during Suppressive ART

G. V. Van Zyl, M. Cotton, M. Kearney, 2021, Viruses.

Rapid decline of HIV-1 DNA and RNA in infants starting very early antiretroviral therapy may pose a diagnostic challenge

J. Mellors, M. Cotton, B. Laughton, 2018, AIDS.

Intrapartum human immunodeficiency virus transmission rate in a central hospital in the Western Cape province after universal antiretroviral therapy roll-out

G. Theron, C. Lombard, Tian van der Merwe, 2020, Southern African journal of infectious diseases.

Lessons in diagnostic virology: expected and unexpected sources of error

Howard Newman, Gert van Zyl, Jean Maritz, 2019, Reviews in medical virology.

Neurodevelopment at 11 months after starting antiretroviral therapy within 3 weeks of life

M. Boivin, M. Cotton, B. Laughton, 2019, Southern African journal of HIV medicine.

Pitfalls with rapid HIV antibody testing in HIV-infected children in the Western Cape, South Africa.

W. Preiser, M. Cotton, G. V. Zyl, 2006, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Virologic efficacy of tenofovir, lamivudine and dolutegravir as second-line antiretroviral therapy in adults failing a tenofovir-based first-line regimen: a prospective cohort study

G. Maartens, Rulan Griesel, G. V. Van Zyl, 2021, AIDS.

Prevalence of Antiretroviral Drug Resistance in Patients Who Are Not Responding to Protease Inhibitor-Based Treatment: Results From the First National Survey in South Africa.

G. V. Van Zyl, W. MacLeod, I. Sanne, 2016, The Journal of infectious diseases.

Antiretroviral Drug Detection in a Community-Randomized Trial of Universal HIV Testing and Treatment: HPTN 071 (PopART)

Kidist Zewdie, H. Ayles, D. Donnell, 2022, Open forum infectious diseases.

Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania

J. M. Brauner, K. Korn, G. V. Van Zyl, 2021, The Journal of antimicrobial chemotherapy.

Primary resistance against integrase strand transfer inhibitors in integrase strand transfer inhibitor-naive patients failing first- and second-line ART in Tanzania

G. V. Van Zyl, W. Preiser, J. Changalucha, 2022, The Journal of antimicrobial chemotherapy.

Moderate levels of preantiretroviral therapy drug resistance in a generalized epidemic: time for better first-line ART?

Wolfgang Preiser, Mathilda Claassen, Peter Bock, 2017, AIDS.

Moderate Levels of Pre-Treatment HIV-1 Antiretroviral Drug Resistance Detected in the First South African National Survey

Dominique Goedhals, Wendy S. Stevens, Ian Sanne, 2016, PloS one.

Delays in HIV-1 infant polymerase chain reaction testing may leave children without confirmed diagnoses in the Western Cape province, South Africa

N. Naidoo, W. Preiser, Nokwazi Nkosi, 2022, African journal of laboratory medicine.

Viral suppression is associated with HIV-antibody level and HIV-1 DNA detectability in early treated children at 2 years of age

M. Cotton, B. Laughton, S. Barnabas, 2021, AIDS.

Comparing mutational pathways to lopinavir resistance in HIV-1 subtypes B versus C

H. Günthard, N. Beerenwinkel, S. Rhee, 2020, bioRxiv.

No evidence of HIV replication in children on antiretroviral therapy.

J. Mellors, B. Luke, J. Coffin, 2017, The Journal of clinical investigation.

HIVIntact: a python-based tool for HIV-1 genome intactness inference

Wei-Shau Hu, J. Coffin, Imogen A. Wright, 2021, Retrovirology.

Intact HIV Proviruses Persist in Children 7-9 Years after Initiation of ART in the First Year of Life

Wei-Shau Hu, J. Mellors, Imogen A. Wright, 2019, SSRN Electronic Journal.

HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens

A. Godzik, W. Fischer, A. Sigal, 2021, Cell Host & Microbe.

Barriers to HIV remission research in low- and middle-income countries

G. V. Van Zyl, J. Tucker, C. Godfrey, 2017, Journal of the International AIDS Society.

Significantly Diminished Long-Term Specificity of the BED Capture Enzyme Immunoassay Among Patients With HIV-1 With Very Low CD4 Counts and Those on Antiretroviral Therapy

J. Hargrove, L. Moulton, A. Welte, 2010, Journal of acquired immune deficiency syndromes.

Perspectives of people living with HIV and health workers about a point-of-care adherence assay: a qualitative study on acceptability

C. Orrell, M. Gandhi, Lauren Jennings, 2023, AIDS care.

An assessment of hepatitis B virus prevalence in South African young blood donors born after the implementation of the infant hepatitis B virus immunization program: Implications for transfusion safety

E. Murphy, R. Swanevelder, M. Vermeulen, 2021, Transfusion.

Prevalence of cardiotropic viruses in adults with clinically suspected myocarditis in South Africa

A. Doubell, M. Claassen, C. Kyriakakis, 2022, Open Heart.

Persistent SARS-CoV-2 infection with accumulation of mutations in a patient with poorly controlled HIV infection

T. de Oliveira, W. Preiser, E. Wilkinson, 2022, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Fatal SARS‐CoV‐2 Omicron variant in a young infant: Autopsy findings

P. Goussard, S. Andronikou, P. Schubert, 2022, Pediatric pulmonology.

UMOYA: a prospective longitudinal cohort study to evaluate novel diagnostic tools and to assess long-term impact on lung health in South African children with presumptive pulmonary TB—a study protocol

P. Goussard, G. Alter, A. Demers, 2023, BMC Pulmonary Medicine.

Understanding the biology, morbidity and social contexts of adolescent tuberculosis: a prospective observational cohort study protocol (Teen TB)

D. Moore, L. Kleynhans, M. M. van der Zalm, 2022, BMJ Open.

Routine use of fluoroscopic and real‐time transthoracic echocardiographic guidance to ensure safety of right ventricular endomyocardial biopsy in a low‐volume center

G. V. Van Zyl, P. Herbst, A. Doubell, 2022, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

High positive HIV serology results can still be false positive

W. Preiser, S. Korsman, J. Reid, 2020, IDCases.

Antiretroviral resistance patterns and factors associated with resistance in adult patients failing NNRTI‐based regimens in the western cape, South Africa

Wolfgang Preiser, Mathilda Claassen, G. V. Van Zyl, 2011, Journal of medical virology.

Evaluation of the Performance of Three Biomarker Assays for Recent HIV Infection Using a Well-Characterized HIV-1 Subtype C Incidence Cohort.

J. Nachega, J. Hargrove, P. Kilmarx, 2019, AIDS research and human retroviruses.

Clinical Presentation and Outcome of Acute Respiratory Illnesses in South African Children During the COVID-19 Pandemic

P. Goussard, R. Dagan, M. M. van der Zalm, 2023, The Pediatric infectious disease journal.

HIV evolution and diversity in ART-treated patients

M. Kearney, M. Bale, G. V. van Zyl, 2018, Retrovirology.

NanoHIV: A Bioinformatics Pipeline for Producing Accurate, Near Full-Length HIV Proviral Genomes Sequenced Using the Oxford Nanopore Technology

Imogen A. Wright, M. Kearney, S. Engelbrecht, 2021, Cells.

Urine tenofovir-monitoring predicts HIV viremia in patients treated with high genetic-barrier regimens

C. Orrell, M. Gandhi, Lauren Jennings, 2022, AIDS.

Drug resistance, rather than low tenofovir levels in blood or urine, is associated with tenofovir, emtricitabine and efavirenz (TEE) failure in resource-limited settings.

C. Orrell, M. Gandhi, Lauren Jennings, 2021, AIDS research and human retroviruses.

NucliSens EasyQ HIV-1 V1.2 system: Detection of human plasma-derived background signal.

W. Preiser, S. Korsman, G. V. van Zyl, 2010, Journal of virological methods.

High burden of viral respiratory co-infections in a cohort of children with suspected pulmonary tuberculosis

A. Demers, M. M. van der Zalm, A. Hesseling, 2020, BMC Infectious Diseases.

Mutational Heterogeneity in p6 Gag Late Assembly (L) Domains in HIV-1 Subtype C Viruses from South Africa.

W. Preiser, G. Jacobs, A. Sonnerborg, 2016, AIDS Research and Human Retroviruses.

Establishing diagnostic cut-off criteria for the COBAS AmpliPrep/COBAS TaqMan HIV-1 Qualitative test through validation against the Amplicor DNA test v1.5 for infant diagnosis using dried blood spots.

G. V. Van Zyl, W. Preiser, J. Maritz, 2012, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Rapid emergence of resistance to antiretroviral treatment after undisclosed prior exposure: A case report

G. V. Van Zyl, T. Rossouw, G. van Dyk, 2019, Southern African journal of HIV medicine.

Acute extrapyramidal dysfunction in two HIV-infected children.

A. Slogrove, B. Marais, R. Solomons, 2011, Journal of tropical pediatrics.

Resistance in Patients Failing Integrase Strand Transfer Inhibitors: A Call to Replace Raltegravir With Dolutegravir in Third-Line Treatment in South Africa

G. V. Van Zyl, K. Steegen, M. Claassen, 2019, Open forum infectious diseases.

Advancing HIV Drug Resistance Technologies and Strategies: Insights from South Africa’s Experience and Future Directions for Resource-Limited Settings

K. Steegen, M. Claassen, R. L. Lebelo, 2023, Diagnostics.

Recycling tenofovir in second-line antiretroviral treatment with dolutegravir: outcomes and viral load trajectories to 72 weeks

G. Maartens, Rulan Griesel, Olina Ngwenya, 2022, Journal of acquired immune deficiency syndromes.

Paper-based detection of HIV-1 drug resistance using isothermal amplification and an oligonucleotide ligation assay

R. Richards-Kortum, G. V. Van Zyl, B. Rohrman, 2018, Analytical biochemistry.

HIV drug resistance in a community‐randomized trial of universal testing and treatment: HPTN 071 (PopART)

C. Fraser, C. Petropoulos, H. Ayles, 2022, Journal of the International AIDS Society.

The largest HIV-1-infected T cell clones in children on long-term combination antiretroviral therapy contain solo LTRs

S. Hughes, J. Mellors, G. V. Van Zyl, 2023, mBio.

Pooled testing: A tool to increase efficiency of infant HIV diagnosis and virological monitoring

W. Preiser, G. V. van Zyl, 2020, African journal of laboratory medicine.

No evidence of HIV replication in children on antiretroviral therapy.

J. Mellors, B. Luke, J. Coffin, 2017, The Journal of clinical investigation.

The effect of interventions on the transmission and spread of HIV in South Africa: a phylodynamic analysis

M. Salemi, T. de Oliveira, G. V. Van Zyl, 2019, Scientific Reports.

SURVEILLANCE OF TRANSMITTED RESISTANCE TO ANTIRETROVIRAL DRUG CLASSES AMONG YOUNG CHILDREN IN THE WESTERN CAPE PROVINCE OF SOUTH AFRICA

G. V. Van Zyl, M. Claassen, G. V. van Zyl, 2009, The Pediatric infectious disease journal.

Low-level viraemia despite emergence of dolutegravir-resistant variants

G. V. Van Zyl, K. Steegen, M.N. Edoo, 2022, Southern African journal of HIV medicine.