J. Lohmann

发表

Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.

N. Keen, S. Wedge, S. Heaton, 2007, Journal of medicinal chemistry.

Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours.

S. Green, Rebecca P A Ellston, B. Barlaam, 2017, Bioorganic & medicinal chemistry letters.

Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours.

S. Green, B. Barlaam, S. Degorce, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of cephalosporins with C-3' catechol-containing residues.

T. G. Bird, J. P. Bailey, F. Jung, 1992, Journal of Medicinal Chemistry.

Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.

J. Kendrew, P. Plé, J. Curwen, 1999, Journal of medicinal chemistry.

Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.

Rajesh Odedra, Stephen Green, Nicola Heron, 2006, Journal of medicinal chemistry.

Alkylation of the isoquinoline skeleton in the 1-position

D. Seebach, M. Yoshifuji, J. Lohmann, 1983 .

Lithiated N‐pivaloyl‐tetrahydroisoquinoline—a Supernuclephile

D. Seebach, M. Yoshifuji, J. Lohmann, 1981 .

Cyclopropenes as Vinylcarbenoids:Intermolecular Carbene‐Addition Reactions of Sulfinyl‐ and Sulfonylcyclopropenes at Room Temperature

M. Franck-Neumann, J. Lohmann, 1977 .

Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: part 2.

S. Barry, J. Kendrew, D. Cross, 2012, Bioorganic & medicinal chemistry letters.

Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3Kβ and PI3Kδ for the treatment of PTEN-deficient cancers.

S. Green, B. Barlaam, S. Degorce, 2015, Journal of medicinal chemistry.