K. Biggadike

发表

Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma.

Stephen A. Smith, L. Lazarides, D. Mallett, 2016, Journal of medicinal chemistry.

Fluticasone furoate/fluticasone propionate – different drugs with different properties

K. Biggadike, 2011, The clinical respiratory journal.

Structure-activity relationship on human serum paraoxonase (PON1) using substrate analogues and inhibitors.

R. Allemann, M. Akhtar, D. Gani, 2003, Bioorganic & medicinal chemistry letters.

Synthesis of Chiral Carbocyclic Nucleosides

A. D. Borthwick, K. Biggadike, 1992 .

Diastereoselective resolution of 6-substituted glycosides via enzymatic hydrolysis.

T. Gallagher, S. Davies, E. N. Vulfson, 1997, Carbohydrate research.

Components for a combinatorial library of rigid azabicyclic α-L-fucose mimics: First X-ray crystal structure of a stable monoalkylated triazene formed by hydrogenation of an azide

D. Watkin, Amanda Harrison, G. Fleet, 1999 .

Inhibition of Fucosyl Transferase and Fucosidase by a Rigid Bicyclic Mimic of α-L-Fucose

B. Winchester, G. Fleet, R. Nash, 1998 .

Photobromination of a bicyclic mimic of α-L-fucose; components for a combinatorial library of rigid fucose analogues

S. Lynn, D. Watkin, G. Fleet, 1999 .

Synthesis of functionalised cephalosporins: diphenylmethyl(1S,6R,7S)-3-bromomethyl-7-formamido-7-methoxyceph-3-em-4-carboxylate-1-oxide: a useful intermediate in the preparation of 7α-methoxycephalosporins

M. Ramsay, K. Biggadike, A. G. Long, 1985 .

Short synthesis of a bicyclic mimic of α-L-fucose

B. Winchester, D. Watkin, G. Fleet, 1994 .

Enzymic glycosylation using 6-substituted glycosides as donor substrates: a novel route to functionalised disaccharides

T. Gallagher, E. Vulfson, S. Davies, 1999 .

Short Synthesis of a Bicyclic Mimic of α-L-Fucose.

B. Winchester, D. Watkin, G. Fleet, 1995 .

Fluorocarbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic 2'-deoxy guanosines.

S. Roberts, J. Coates, D. Ryan, 1991, Journal of medicinal chemistry.

Enzymic Glycosylation Using 6-Substituted Glycosides as Donor Substrates: A Novel Route to Functionalized Disaccharides.

T. Gallagher, E. Vulfson, S. Davies, 1999 .

3'-deoxy-3'-fluoro-xylo-neplanocin A

A. D. Borthwick, K. Biggadike, 1992 .

4′-Modification of carbocyclic nucleosides: synthesis of 4′-α-fluoro, 4′α-hydroxy and 4′,6′-unsaturated derivatives of the antiviral agent 2′-ara-fluoro carbocyclic guanosine

A. D. Borthwick, K. Biggadike, 1990 .

Enantiospecific synthesis of the potent anti-herpetic carbocyclic 9-(2′deoxy-2′-flouro-β-D-arabinofuranosyl) guanine (+)CAFG from arsiteromycin

A. D. Borthwick, K. Biggadike, C. Mo, 1990 .

Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil.

S. Roberts, J. Coates, B. E. Kirk, 1990, Journal of medicinal chemistry.

Synthesis and enzymatic resolution of carbocyclic 2′-ara-fluoro-guanosine: a potent new anti-herpetic agent

J. Cameron, S. Roberts, B. E. Kirk, 1988 .

Use of diethylaminosulphur trifluoride (DAST) in the preparation of synthons of carbocyclic nucleosides

S. Roberts, B. E. Kirk, A. D. Borthwick, 1988 .

Synthesis and Enzymatic Resolution of Carbocyclic 2′-Ara-fluoroguanosine (I): A Potent New Anti-Herpetic Agent.

J. Cameron, S. Roberts, B. E. Kirk, 1988 .

Short convergent route to chiral pyrimidine analogues of 2′-deoxy neplanocin A

A. D. Borthwick, A. M. Exall, K. Biggadike, 1990 .

Use of Diethylaminosulfur Trifluoride (DAST) in the Preparation of Synthons of Carbocyclic Nucleosides.

S. Roberts, B. E. Kirk, A. D. Borthwick, 1988 .

Synthesis of fluorinated carbocyclic nucleosides: preparation of (±)-carbocyclic-FMAU and some congeners

A. Slawin, B. E. Kirk, A. D. Borthwick, 1987 .

Short convergent route to homochiral carbocyclic-2′-deoxynucleosides and carbocyclic ribonucleosides

S. Roberts, B. E. Kirk, A. D. Borthwick, 1987 .

Synthesis of fluorinated carbocyclic nucleosides: preparation of carbocyclic 1-(2′-deoxy-6′-fluororibofuranosyl)-5-iodouracils

A. Slawin, S. Roberts, B. E. Kirk, 1987 .

Short Convergent Route to Chiral Pyrimidine Analogues of 2′-Deoxy Neplanocin A.

A. D. Borthwick, A. M. Exall, K. Biggadike, 1990 .

Synthesis of Fluorinated Carbocyclic Nucleosides: Preparation of (.+-.)-Carbocyclic-FMAU and Some Congeners.

A. Slawin, S. Roberts, B. E. Kirk, 1987 .

Chiral carbocylic nucleosides: The synthesis and antiviral activity of 4′-hydroxy and 4′-fluorocarbocyclic - 2′- deoxyguanosines

J. Coates, I. L. Paternoster, A. D. Borthwick, 1993 .

Short Convergent Route to Homochiral Carbocyclic 2′-Deoxynucleosides and Carbocyclic Ribonucleosides.

S. Roberts, B. E. Kirk, A. D. Borthwick, 1988 .

Synthesis of Fluorinated Carbocyclic Nucleosides: Preparation of Carbocyclic 1-(2′-Deoxy-6′-fluororibofuranosyl)-5-iodouracils.

A. Slawin, S. Roberts, B. E. Kirk, 1987 .

6.Alpha.,9.alpha.-difluoro-17.alpha.-'(2-furanylcarboxyl) oxy]-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothiotic acid s-fluoromethyl ester comme agent anti-inflammatoire

S. J. Coote, K. Biggadike, R. Nice, 2001 .

Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism.

R. Angell, O. Singh, K. Biggadike, 2000, Journal of medicinal chemistry.