Fengwei Lin

发表

Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.

Jun Gao, Peng Zhang, R. Dai, 2021, European journal of medicinal chemistry.

Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7.

Lei Zhang, Yan-hua Mou, Peng Zhang, 2022, European journal of medicinal chemistry.

Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5-ASA-PABA-MAC and 5-ASA-PABA-Diamine for the Treatment of Ulcerative Colitis.

Qiushi Li, Yan-hua Mou, Ting-jian Zhang, 2022, Journal of medicinal chemistry.

Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors.

Ting-jian Zhang, M. Sun, Bing Zhang, 2021, European journal of medicinal chemistry.

Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.

Jun Gao, Ming Sun, Bing Zhang, 2021, Bioorganic & medicinal chemistry.

Thiazolidinedione-Based Structure Modification of Celastrol Provides Thiazolidinedione-Conjugated Derivatives as Potent Agents against Non-Small-Cell Lung Cancer Cells through a Mitochondria-Mediated Apoptotic Pathway.

Yan-hua Mou, Bing Zhang, Qing Mao, 2022, Journal of natural products.

Synthesis and evaluation of the alpha-glucosidase inhibitory activity of 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives.

Ting-jian Zhang, Shaojie Wang, Ju-fang Yan, 2010, European journal of medicinal chemistry.

Identification of 5-[5-cyano-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamido] thiazole-4-carboxylic acid as a promising dual inhibitor of urate transporter 1 and xanthine oxidase.

Jun Gao, M. Sun, Bing Zhang, 2023, European journal of medicinal chemistry.

Synthesis and evaluation of the alpha-glucosidase inhibitory activity of 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives.

Ting-jian Zhang, Shaojie Wang, Ju-fang Yan, 2010, European journal of medicinal chemistry.