P. Haile

发表

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

Aditya R. Thawani, I. E. Smith, Carol A. Capriotti, 2020, Communications Biology.

Optimization of a Series of RIPK2 PROTACs.

Aditya R. Thawani, I. E. Smith, R. Nagilla, 2021, Journal of medicinal chemistry.

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[ d]thiazol-5-ylamino)-6-( tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.

J. Bertin, K. Erhard, M. Convery, 2019, Journal of medicinal chemistry.

CCR2 receptor antagonists: optimization of biaryl sulfonamides to increase activity in whole blood.

J. Briand, C. Chung, N. Varga, 2011, Bioorganic & medicinal chemistry letters.

Ion-molecule chemistry within boron tribromide clusters: experiment and theory.

D. A. Hales, K. E. Kautzman, P. Haile, 2007, The journal of physical chemistry. A.

Enantioselective total synthesis of brevetoxin A: unified strategy for the B, E, G, and J subunits.

K. A. Emmitte, M. Crimmins, J. Ellis, 2009, Chemistry.

Total synthesis of brevetoxin A.

K. Nicolaou, K. A. Emmitte, J. Gunzner, 2009, Organic letters.

Silylene oxonium ylides: di-tert-butylsilylene insertion into C-O bonds.

K. Woerpel, P. Haile, Janice M. N. Loy, 2009, Tetrahedron.

RIP3 induces apoptosis independent of pronecrotic kinase activity.

Kenta Moriwaki, Viera Kasparcova, John Bertin, 2014, Molecular cell.

Silylene-mediated ring contraction of homoallylic ethers to form allylic silanes.

K. Woerpel, P. Haile, Laura E. Bourque, 2009, The Journal of organic chemistry.

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.

J. Bertin, K. Erhard, D. Lipshutz, 2019 .

The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.

Carol A. Capriotti, J. Bertin, M. Convery, 2016, Journal of medicinal chemistry.

Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.

Joseph P. Romano, N. C. Goodwin, J. Bertin, 2019, ACS medicinal chemistry letters.

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.

J. Bertin, M. Convery, D. Lipshutz, 2018, ACS medicinal chemistry letters.

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

Aditya R. Thawani, I. E. Smith, M. Bantscheff, 2020, Communications Biology.

Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway

J. Bertin, V. Kasparcova, Jong W. Yu, 2013, PloS one.

EVIDENCE FOR TONE-SPECIFIC ACrIVITY OF THE STERNOHYOID MUSCLE lN MODERN STANDARD CHINESE

P. Haile, 2004 .

Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway

J. Bertin, V. Kasparcova, Zining Wu, 2014, PloS one.

Understanding Pharmacokinetic Disconnect in Preclinical Species for 4-Aminoquinolines: Consequences of Low Permeability and High P-glycoprotein Efflux Ratio on Rat and Dog Oral Pharmacokinetics.

J. Bertin, M. Mahajan, R. Nagilla, 2020, Journal of pharmaceutical sciences.

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.

Carol A. Capriotti, J. Bertin, M. Convery, 2018, ACS medicinal chemistry letters.