Yoshihiko Saito

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Roles of Natriuretic Peptides and the Significance of Neprilysin in Cardiovascular Diseases

H. Nakagawa, Yoshihiko Saito, 2022, Biology.

Isolation and sequence determination of human brain natriuretic peptide in human atrium

K. Nakao, H. Imura, K. Inouye, 1990, FEBS letters.

NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function

K. Nakao, A. Noma, M. Horie, 2003, The EMBO journal.

Atrial natriuretic peptides predict mortality in the elderly

K. Nakao, T. Hedner, S. Landahl, 1997, Journal of internal medicine.

Expression of Brain Natriuretic Peptide Gene in Human Heart: Production in the Ventricle

H. Imura, K. Hosoda, M. Mukoyama, 1991, Hypertension.

The Effects of Atrial Natriuretic Peptide Infusion on Hemodynamic, Renal, and Hormonal Responses During Gastrectomy

K. Shingu, Y. Saito, K. Nakao, 1997, Anesthesia and analgesia.

Effects of Anesthesia and Surgery on Plasma Endothelin Levels

K. Shingu, Y. Saito, K. Nakao, 1995, Anesthesia and analgesia.

Identification and distribution of atrial natriuretic polypeptide in ventricular myocardium of humans with myocardial infarction

H. Imura, M. Mukoyama, T. Uegaito, 1990, The Journal of pathology.

Endothelial nitric oxide synthase gene is positively associated with essential hypertension.

H. Itoh, I. Masuda, T. Akamizu, 1998, Hypertension.

T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.

K. Nakao, K. Kugiyama, H. Ogawa, 1999, Circulation.

T(-786)--> C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis.

K. Nakao, K. Kugiyama, H. Ogawa, 2000, The American journal of cardiology.

Significance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy: evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes.

T. Igaki, H. Itoh, I. Masuda, 1997, Circulation.

Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy.

K. Bailey, K. Nakao, R. Nishimura, 1996, Hypertension.

Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes.

I. Kishimoto, Y. Miyamoto, I Kishimoto, 2000, Journal of molecular and cellular cardiology.

Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.

K. Inouye, M. Mukoyama, S. Suga, 1991, The Journal of clinical investigation.

Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats.

K. Hosoda, M. Mukoyama, S. Suga, 1991, Life sciences.

Brain natriuretic peptide predicts mortality in the elderly.

K. Nakao, T. Hedner, S. Landahl, 1997, Heart.

Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction.

H Yasue, K. Nakao, K. Kugiyama, 1998, Journal of the American College of Cardiology.

Brain natriuretic peptide is a novel cardiac hormone.

H. Itoh, K. Hosoda, N. Minamino, 1989, Biochemical and biophysical research communications.

Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart.

K. Hosoda, H. Arai, M. Mukoyama, 1989, The Journal of clinical investigation.

Expression of atrial and brain natriuretic peptides and their genes in hearts of patients with cardiac amyloidosis.

H. Itoh, G. Takemura, H. Fujiwara, 1998, Journal of the American College of Cardiology.

Cardiac fibrosis in mice lacking brain natriuretic peptide.

Kenji Nakamura, M. Katsuki, N. Tamura, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure.

T. Ishimitsu, K. Kangawa, H. Matsuo, 1994, The Journal of clinical investigation.

A T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility.

K. Nakao, K. Kugiyama, H. Ogawa, 2000, The American journal of cardiology.

Genetic risk factors for coronary artery spasm: significance of endothelial nitric oxide synthase gene T-786-->C and missense Glu298Asp variants.

K. Nakao, K. Kugiyama, H. Ogawa, 2000, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

Lack of association between T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and essential hypertension.

K. Nakao, I. Kishimoto, H. Yasue, 2000, Hypertension research : official journal of the Japanese Society of Hypertension.

Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T-->C mutation associated with coronary spastic angina.

K. Kangawa, I. Kishimoto, H. Yasue, 2000, Human molecular genetics.

Atrial natriuretic peptide secretion and body fluid balance after bilateral atrial appendectomy by the maze procedure.

F. Yoshihara, K. Kangawa, Y. Kawashima, 1998, The Journal of thoracic and cardiovascular surgery.

Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide.

K. Hosoda, H. Arai, K. Inouye, 1992, Endocrinology.

Outside-in signalling of fibronectin stimulates cardiomyocyte hypertrophy in cultured neonatal rat ventricular myocytes.

I. Masuda, O. Nakagawa, I. Kishimoto, 2000, Journal of molecular and cellular cardiology.

Roles of natriuretic peptides in heart failure.

H. Itoh, I. Masuda, O. Nakagawa, 1996, Journal of cardiac failure.

Increased human brain natriuretic peptide in congestive heart failure.

H. Imura, K. Hosoda, M. Mukoyama, 1990, The New England journal of medicine.

Vasodilator therapy with hydralazine induces angiotensin AT2 receptor‐mediated cardiomyocyte growth in mice lacking guanylyl cyclase‐A

M. Horiuchi, I. Kishimoto, M. Harada, 2010, British journal of pharmacology.

Suppression of endothelin-1 secretion by lysophosphatidylcholine in oxidized low density lipoprotein in cultured vascular endothelial cells.

K. Nakao, K. Kugiyama, H. Imura, 1992, Circulation research.

Exacerbation of diabetic nephropathy by hyperlipidaemia is mediated by Toll-like receptor 4 in mice

H. Yokoi, K. Nakao, T. Kuwabara, 2012, Diabetologia.

Association of autoimmune thyroid disease with microsatellite markers for the thyrotropin receptor gene and CTLA-4 in Japanese patients.

S. Rich, D. Bowden, T. Akamizu, 2000, Thyroid : official journal of the American Thyroid Association.

Effects of cardiotrophin-1 on hemodynamics and endocrine function of the heart.

I. Masuda, I. Kishimoto, T. Nishikimi, 2000, American journal of physiology. Heart and circulatory physiology.

Plasma levels of adrenomedullin in primary and secondary pulmonary hypertension in patients <20 years of age.

K. Kangawa, T. Kamiya, H. Matsuo, 1997, The American journal of cardiology.

Increased plasma levels of adrenomedullin in patients with heart failure.

T. Ishimitsu, K. Kangawa, H. Matsuo, 1995, Journal of the American College of Cardiology.

A heart-specific increase in cardiotrophin-1 gene expression precedes the establishment of ventricular hypertrophy in genetically hypertensive rats.

I. Masuda, O. Nakagawa, T. Hosoya, 1999, Journal of hypertension.

Endothelin in human plasma and culture medium of aortic endothelial cells--detection and characterization with radioimmunoassay using monoclonal antibody.

H. Itoh, K. Hosoda, H. Arai, 1989, Biochemical and biophysical research communications.

Blockade of the natriuretic peptide receptor guanylyl cyclase-A inhibits NF-kappaB activation and alleviates myocardial ischemia/reperfusion injury.

D. Garbers, G. Takemura, I. Kishimoto, 2001, The Journal of clinical investigation.

Involvement of cardiotrophin-1 in cardiac myocyte-nonmyocyte interactions during hypertrophy of rat cardiac myocytes in vitro.

I. Masuda, O. Nakagawa, Y. Miyamoto, 1999, Circulation.

The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity.

K. Nakao, K. Kugiyama, R. Tsunoda, 2000, The Journal of clinical endocrinology and metabolism.

Increased plasma endothelin level in patients with essential hypertension.

K. Nakao, H. Imura, M. Mukoyama, 1990, The New England journal of medicine.

Two cardiac natriuretic peptide genes (atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes.

N. Tamura, H. Itoh, A. Yasoda, 1996, Journal of molecular and cellular cardiology.

Antihypertensive therapy reduces increased plasma levels of adrenomedullin and brain natriuretic peptide concomitant with regression of left ventricular hypertrophy in a patient with malignant hypertension.

F. Yoshihara, Y. Kawano, K. Kangawa, 1996, Hypertension research : official journal of the Japanese Society of Hypertension.

Expression and distribution of atrial natriuretic polypeptide in the ventricles of children with myocarditis and/or myocardial infarction secondary to Kawasaki disease: immunohistochemical study.

M. Nakano, H. Imura, M. Mukoyama, 1990, American heart journal.

Different secretion patterns of adrenomedullin, brain natriuretic peptide, and atrial natriuretic peptide during exercise in hypertensive and normotensive subjects.

K. Kangawa, H. Matsuo, K. Ishikawa, 1997, Clinical and experimental hypertension.

Increased plasma level of endothelin-1-like immunoreactivity during coronary spasm in patients with coronary spastic angina.

K. Nakao, K. Okumura, H. Imura, 1991, The American journal of cardiology.

Interaction of myocytes and nonmyocytes is necessary for mechanical stretch to induce ANP/BNP production in cardiocyte culture.

H. Itoh, I. Masuda, O. Nakagawa, 1998, Journal of cardiovascular pharmacology.

Plasma brain natriuretic peptide concentrations in healthy children from birth to adolescence: marked and rapid increase after birth.

K. Nakao, H. Itoh, K. Nishioka, 1995, European journal of endocrinology.

Rat brain natriuretic peptide--tissue distribution and molecular form.

H. Itoh, K. Hosoda, H. Arai, 1990, Endocrinology.

Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy.

K. Nakao, H. Tanaka, Xinwen Wang, 2001, Journal of the American College of Cardiology.

Central effect of atrial natriuretic polypeptide on angiotensin II-stimulated vasopressin secretion in conscious rats.

H. Itoh, K. Nakao, A. Sugawara, 1986, European journal of pharmacology.

Atrial natriuretic polypeptide in spinal cord and autonomic ganglia.

H. Itoh, M. Mukoyama, K. Nakao, 1987, Biochemical and biophysical research communications.