I. A. Murray

发表

Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver.

G. Perdew, I. Murray, A. Patterson, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Restriction Cascade Exponential Amplification (RCEA) assay with an attomolar detection limit: a novel, highly specific, isothermal alternative to qPCR

A. Ghindilis, Shuang-yong Xu, Ihab Seoudi, 2015, Scientific Reports.

Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site.

W. V. Shaw, A. Leslie, M. Sutcliffe, 1995, Journal of molecular biology.

Identification of a high affinity ligand that exhibits complete Ah receptor antagonism

Anthony E. Boitano, M. Cooke, G. Perdew, 2011 .

Peroxisome Proliferator-activated Receptor-β/δ Inhibits Epidermal Cell Proliferation by Down-regulation of Kinase Activity*

J. Peters, F. Gonzalez, G. Perdew, 2005, Journal of Biological Chemistry.

Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression*

G. Perdew, I. Murray, C. Omiecinski, 2016, The Journal of Biological Chemistry.

Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice.

G. Perdew, Kayla J. Smith, Jacob A. Boyer, 2018, Toxicology.

Persistent Organic Pollutants Modify Gut Microbiota–Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation

I. Albert, A. Sebastian, F. Gonzalez, 2015, Environmental health perspectives.

Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders.

G. Perdew, I. Murray, G. Rikken, 2022, Biochemical pharmacology.

Properties of hybrid active sites in oligomeric proteins: kinetic and ligand binding studies with chloramphenicol acetyltransferase trimers.

W. V. Shaw, I. Murray, P. Day, 1995, Biochemistry.

Analysis of hydrogen bonding in enzyme-substrate complexes of chloramphenicol acetyltransferase by infrared spectroscopy and site-directed mutagenesis.

W. V. Shaw, C. Wharton, J. Derrick, 1994, Biochemistry.

Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus).

Imhoi Koo, G. Perdew, I. Murray, 2019, Journal of agricultural and food chemistry.

Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties.

S. Amin, G. Perdew, I. Murray, 2010, Chemical research in toxicology.

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

S. Amin, Guray Kuzu, G. Perdew, 2019, Laboratory Investigation.

Aryl hydrocarbon receptor ligands in cancer: friend and foe

G. Perdew, I. Murray, A. Patterson, 2014, Nature Reviews Cancer.

Suppression of Cytokine-Mediated Complement Factor Gene Expression through Selective Activation of the Ah Receptor with 3′,4′-Dimethoxy-α-naphthoflavone

William H. Bisson, Siva K Kolluri, S. Amin, 2011, Molecular Pharmacology.

Evidence for Ligand-Mediated Selective Modulation of Aryl Hydrocarbon Receptor Activity

S. Amin, G. Perdew, I. Murray, 2010, Molecular Pharmacology.

How Ah Receptor Ligand Specificity Became Important in Understanding Its Physiological Function

G. Perdew, I. Murray, I. A. Murray, 2020, International journal of molecular sciences.

Evidence supporting a cis-enediol-based mechanism for Pyrococcus furiosus phosphoglucose isomerase.

Stan J. J. Brouns, Jasper Akerboom, D. Rice, 2006, Journal of molecular biology.

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran

Imhoi Koo, G. Perdew, I. Murray, 2019, Metabolites.

Targeting the pregnane X receptor using microbial metabolite mimicry

S. Vishveshwara, S. Kortagere, M. Redinbo, 2019, bioRxiv.

Indoleamine 2,3‐dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor

C. Tomlinson, G. Perdew, I. Murray, 2017, Toxicology and applied pharmacology.

Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling.

C. J. Omiecinski, G. Perdew, I. Murray, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

The role of magnesium ions and 2'-hydroxyl groups in the VS ribozyme-substrate interaction.

J. Grasby, S. Tzokov, I. A. Murray, 2002, Journal of molecular biology.

Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing

Richard J. Roberts, Jonas Korlach, Tyson A. Clark, 2011, Nucleic acids research.

The Aryl Hydrocarbon Receptor Activates Ceramide Biosynthesis in Mice Contributing to Hepatic Lipogenesis.

M. Anitha, G. Perdew, I. Murray, 2021, Toxicology.

Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation

G. Perdew, I. Murray, T. Hubbard, 2015, Drug Metabolism and Disposition.

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor.

S. Strom, S. Amin, Qiang Liu, 2010, Biochemistry.

Selective Aryl Hydrocarbon Receptor Modulator-Mediated Repression of CD55 Expression Induced by Cytokine Exposure

S. Amin, G. Perdew, I. Murray, 2012, Journal of Pharmacology and Experimental Therapeutics.

Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing

Tyson A. Clark, J. Korlach, M. Mahajan, 2012, Nature Biotechnology.

Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice

G. Perdew, I. Murray, A. Patterson, 2016, Scientific Reports.

The non-specific adenine DNA methyltransferase M.EcoGII

R. Roberts, Xiaodong Cheng, R. Morgan, 2017, Nucleic acids research.

The non-specific adenine DNA methyltransferase M.EcoGII

Richard, R. Roberts, Xiaodong Cheng, 2017, Nucleic acids research.

The methylomes of six bacteria

Richard J. Roberts, Stephen W. Turner, Jonas Korlach, 2012, Nucleic acids research.

High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity.

D. Rice, S. Sedelnikova, I. Murray, 2003, Journal of molecular biology.

Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis.

G. Perdew, I. Murray, I. A. Murray, 2017, Current opinion in toxicology.

Plasmid replication-associated single-strand-specific methyltransferases

R. Roberts, E. Raleigh, A. Fomenkov, 2020, Nucleic acids research.

Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist

G. Perdew, J. Espín, I. Murray, 2018, Metabolites.

Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming.

D. Desai, G. Perdew, I. Murray, 2023, Laboratory investigation; a journal of technical methods and pathology.

Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome

G. Perdew, I. Murray, Gulsum E. Muku, 2019, Current Pharmacology Reports.

Editor’s Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin

S. Amin, D. Desai, G. Perdew, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Dietary Broccoli Impacts Microbial Community Structure and Attenuates Chemically Induced Colitis in Mice in an Ah receptor dependent manner.

Yuan Tian, Guray Kuzu, G. Perdew, 2017, Journal of functional foods.

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

William H. Bisson, S. Amin, G. Perdew, 2015, Scientific Reports.

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

P. Kris-Etherton, S. Amin, Imhoi Koo, 2020, Gut microbes.

Replacement of catalytic histidine-195 of chloramphenicol acetyltransferase: evidence for a general base role for glutamate.

W. V. Shaw, A. Leslie, I. Murray, 1994, Biochemistry.

Ligand Activation of Peroxisome Proliferator–Activated Receptor b / d (PPAR b / d ) Attenuates Carbon Tetrachloride Hepatotoxicity by Downregulating Proinﬂammatory Gene Expression

J. Peters, F. Gonzalez, G. Perdew, 2008 .

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element‐independent manner

G. Perdew, I. Murray, A. Patterson, 2012, Hepatology.

Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression.

J. Peters, F. Gonzalez, G. Perdew, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase.

A. G. Day, C. Craik, I. Murray, 2004, The Biochemical journal.

O-Acetyltransferases for chloramphenicol and other natural products

W. V. Shaw, I. Murray, I. A. Murray, 1997, Antimicrobial agents and chemotherapy.

Aryl Hydrocarbon Receptor Antagonism Attenuates Growth Factor Expression, Proliferation, and Migration in Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis

S. Amin, J. Peters, G. Perdew, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes

S. Amin, G. Perdew, I. Murray, 2013, Annals of the rheumatic diseases.

Aryl Hydrocarbon Receptor Activation Synergistically Induces Lipopolysaccharide-Mediated Expression of Proinflammatory Chemokine (c-c motif) Ligand 20.

G. Perdew, I. Murray, A. Kusnadi, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Differential gene regulation by the human and mouse aryl hydrocarbon receptor.

G. Perdew, I. Murray, Colin A. Flaveny, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Substitutions in the active site of chloramphenicol acetyltransferase: role of a conserved aspartate.

I A Murray, A Lewendon, P M Cullis, 1988, Biochemistry.

Structural and functional diversity among Type III restriction-modification systems that confer host DNA protection via methylation of the N4 atom of cytosine

Tyson A. Clark, J. Korlach, R. Roberts, 2021, PloS one.

Role of Chaperone Proteins in AHR Function

G. Perdew, I. Murray, I. A. Murray, 2011 .

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

D. Desai, Imhoi Koo, G. Perdew, 2023, bioRxiv.

Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses

S. Amin, Guray Kuzu, G. Perdew, 2017, Laboratory investigation; a journal of technical methods and pathology.

Identification of a High-Affinity Ligand That Exhibits Complete Aryl Hydrocarbon Receptor Antagonism

Anthony E. Boitano, M. Cooke, G. Perdew, 2011, Journal of Pharmacology and Experimental Therapeutics.

The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis.

Stan J. J. Brouns, Jasper Akerboom, D. Rice, 2004, Journal of molecular biology.

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline.

S. Amin, G. Perdew, I. Murray, 2019, Journal of proteome research.

Divergent Ah Receptor Ligand Selectivity during Hominin Evolution.

William H. Bisson, G. Perry, N. Jablonski, 2016, Molecular biology and evolution.

Interaction of glucocorticoid receptor isoforms with transcription factors AP-1 and NF-κB: lack of effect of glucocorticoid receptor β

Julian R. E. Davis, Anne White, I. Brogan, 1999, Molecular and Cellular Endocrinology.

Contribution of circulating host and microbial tryptophan metabolites towards Ah receptor activation

P. Kris-Etherton, G. Perdew, A. Annalora, 2023, bioRxiv.

Sequence-specific cleavage of RNA by Type II restriction enzymes

R. Roberts, S. Stickel, I. Murray, 2010, Nucleic acids research.

Regulation of antibiotic resistance in bacteria: the chloramphenicol acetyltransferase system.

W. V. Shaw, I. Murray, D. Brenner, 1985, Current topics in cellular regulation.

A flow cytometric technique for simultaneous analysis of human mononuclear cell surface antigens and DNA.

A. Givan, I. Murray, B. Shenton, 1989, Journal of immunological methods.

Mechanisms: Xenobiotic Receptor-Mediated Toxicity

J. Peters, G. Perdew, I. Murray, 2018 .

Antagonism of Aryl Hydrocarbon Receptor Signaling by 6,2′,4′-Trimethoxyflavone

G. Perdew, I. Murray, Colin A. Flaveny, 2010, Journal of Pharmacology and Experimental Therapeutics.

Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy*

A. Fornace, J. Peters, F. Gonzalez, 2016, The Journal of Biological Chemistry.

Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice

G. Perdew, I. Murray, C. Chiaro, 2009, Molecular Pharmacology.

Xenobiotic Receptor-Mediated Toxicity

J. Peters, G. Perdew, I. Murray, 2010 .

Cellular and Pharmacological Selectivity of the Peroxisome Proliferator-Activated Receptor-β/δ Antagonist GSK3787

S. Amin, J. Peters, R. Müller, 2010, Molecular Pharmacology.

Structural and Functional Analysis of the Gut Microbiome for Toxicologists

Imhoi Koo, G. Perdew, I. Murray, 2018, Current protocols in toxicology.

Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice.

J. Peters, F. Gonzalez, G. Perdew, 2016, Toxicology.

Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity.

J. Peters, F. Gonzalez, G. Perdew, 2005, The Journal of biological chemistry.

Structural Basis of Synercid® (Quinupristin-Dalfopristin) Resistance in Gram-positive Bacterial Pathogens*

J. Rafferty, I. Murray, P. Courvalin, 2003, Journal of Biological Chemistry.

Alternative binding modes for chloramphenicol and 1-substituted chloramphenicol analogues revealed by site-directed mutagenesis and X-ray crystallography of chloramphenicol acetyltransferase.

I A Murray, A Lewendon, J A Williams, 1991, Biochemistry.

Nucleotide sequences of genes encoding the type II chloramphenicol acetyltransferases of Escherichia coli and Haemophilus influenzae, which are sensitive to inhibition by thiol-reactive reagents.

I A Murray, W V Shaw, W. V. Shaw, 1990, The Biochemical journal.

Evidence for transition-state stabilization by serine-148 in the catalytic mechanism of chloramphenicol acetyltransferase.

I A Murray, A Lewendon, W V Shaw, 1990, Biochemistry.

Nucleotide sequence of the chloramphenicol acetyltransferase gene of Streptomyces acrimycini.

W. V. Shaw, I. Murray, D. Hopwood, 1989, Gene.

Nucleotide sequence analysis and overexpression of the gene encoding a type III chloramphenicol acetyltransferase.

I A Murray, W V Shaw, W. V. Shaw, 1988, The Biochemical journal.

Ah receptor represses acute phase response gene expression without binding to its cognate response element

G. Perdew, I. Murray, Colin A. Flaveny, 2009, Laboratory Investigation.

Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.

S. Amin, G. Perdew, I. Murray, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Intrinsic fluorescence of chloramphenicol acetyltransferase: responses to ligand binding and assignment of the contributions of tryptophan residues by site-directed mutagenesis.

W. V. Shaw, I. Murray, J. Ellis, 1991, Biochemistry.

Complex chemical signals dictate Ah receptor activation through the gut–lung axis

D. Desai, Imhoi Koo, G. Perdew, 2023, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback

G. Perdew, A. Annalora, C. Marcus, 2023, International journal of tryptophan research : IJTR.

Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity.

Laura Bonati, Jeffrey M Peters, J. Peters, 2005, Archives of biochemistry and biophysics.

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

G. Perdew, I. Murray, A. Patterson, 2023, Journal of functional foods.