Deanna Mohn

发表

Defining dose-response relationships in the therapeutic blockade of B7RP-1-dependent immune responses.

M. Dalphin, T. Horan, R. Deshpande, 2009, European journal of pharmacology.

Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.

P. Gallant, A. Oliveira-dos-Santos, J. Newcomb, 2008, Journal of medicinal chemistry.

Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors

D. Whittington, Yi Chen, K. Miner, 2012 .

Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quino

J. McCarter, D. Whittington, Iain D. G. Campuzano, 2016, Journal of medicinal chemistry.

Synthesis and SAR study of potent and selective PI3Kδ inhibitors.

J. McCarter, D. Metz, S. Wong, 2015, Bioorganic & medicinal chemistry letters.

Discovery and in vivo evaluation of dual PI3Kβ/δ inhibitors.

D. Whittington, Yi Chen, K. Miner, 2012, Journal of medicinal chemistry.

Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.

Xin Huang, David Powers, Daniela Metz, 2006, Journal of medicinal chemistry.

Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.

J. McCarter, D. Whittington, D. Metz, 2016, Journal of medicinal chemistry.

Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.

Xiaolin Hao, Ben Fisher, Andreas Reichelt, 2015, Journal of medicinal chemistry.

A nanoparticle vaccine that targets neoantigen peptides to lymphoid tissues elicits robust antitumor T cell responses

H. Phee, Charles Glaus, J. Lipford, 2020, npj Vaccines.

A nanoparticle vaccine that targets neoantigen peptides to lymphoid tissues elicits robust antitumor T cell responses

J. Johnston, H. Phee, Charles Glaus, 2020, NPJ vaccines.

Diverse alterations associated with resistance to KRAS(G12C) inhibition

M. Berger, J. Reis-Filho, B. Weigelt, 2021, Nature.

IL-17RA Signaling in Airway Inflammation and Bronchial Hyperreactivity in Allergic Asthma.

K. Misura, E. Rickel, J. Sullivan, 2015, American journal of respiratory cell and molecular biology.

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

Dirk E. Smith, J. Johnston, O. Homann, 2018, bioRxiv.

Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.

P. Gallant, M. Morrison, D. Elbaum, 2006, Journal of medicinal chemistry.