T. Yasuma

发表

Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.

Masahiro Ito, Toshimasa Tanaka, S. Mikami, 2010, ACS medicinal chemistry letters.

Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent.

Masahiro Ito, S. Mikami, K. Takeuchi, 2012, Journal of medicinal chemistry.

Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition.

Masaharu Nakayama, S. Okuda, Masashi Takahashi, 2016, Bioorganic & medicinal chemistry.

Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists.

Masahiro Ito, Toshimasa Tanaka, K. Takeuchi, 2012, Journal of medicinal chemistry.

NAD(P)+–NAD(P)H Models. 59. 1,2- Versus 1,4-Reduction of β,γ-Unsaturated α-Keto Ester

Kaoru Nakamura, A. Ohno, T. Yasuma, 1986 .

Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption.

Y. Fujisawa, T. Sohda, A. Nishimura, 1998, Journal of medicinal chemistry.

Studies on disease-modifying antirheumatic drugs. IV. Synthesis of novel thieno[2,3-b:5,4-c']dipyridine derivatives and their anti-inflammatory effect.

S. Unno, A. Mori, T. Sohda, 1999, Chemical & pharmaceutical bulletin.

Novel and potent calcium-sensing receptor antagonists: discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent.

Y. Ikeda, T. Kawamoto, S. Morimoto, 2011, Bioorganic & medicinal chemistry.

Discovery of novel and potent orally active calcium-sensing receptor antagonists that stimulate pulselike parathyroid hormone secretion: synthesis and structure-activity relationships of tetrahydropyrazolopyrimidine derivatives.

Y. Ikeda, T. Kawamoto, A. Mori, 2011, Journal of medicinal chemistry.

Synthesis and structure-activity relationship of tetrahydropyrazolopyrimidine derivatives--a novel structural class of potent calcium-sensing receptor antagonists.

T. Kawamoto, M. Yamaguchi, A. Mori, 2010, Bioorganic & medicinal chemistry.

Preparation of (2,3-Dihydrobenzofuran-3-yl)acetic Acid via Rh-Catalyzed Asymmetric Hydrogenation

T. Yamano, M. Yamashita, N. Negoro, 2014 .

NAD(P)+‐NADPH Models. 60. Induction of Double Asymmetry in the Reduction of α‐Keto Esters

Kaoru Nakamura, A. Ohno, T. Yasuma, 1987 .

Nad(p)+-nad(p)h models. 50. Stereo-controlled reduction of methyl 2-oxo-3-methylpentanoate

A. Ohno, Heehwa Joung, T. Yasuma, 1984 .

TAK-875, an Orally Available G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist, Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats

K. Takeuchi, Masami Suzuki, Y. Momose, 2011, Journal of Pharmacology and Experimental Therapeutics.

Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes.

Toshimasa Tanaka, S. Mikami, Masami Suzuki, 2012, Journal of medicinal chemistry.

Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure-Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives.

Masaharu Nakayama, Masashi Takahashi, H. Hirabayashi, 2016, Journal of medicinal chemistry.

Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists.

Toshimasa Tanaka, Masami Suzuki, M. Harada, 2011, Journal of medicinal chemistry.

Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure-Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives.

Masaharu Nakayama, Masashi Takahashi, H. Hirabayashi, 2016, Journal of Medicinal Chemistry.