Omar Delgado

发表

AMD-associated SNPs in the ARMS2/HTRA1 locus influence local gene expression in multiple human tissues

T. Dryja, B. Jaffee, M. Crowley, 2016 .

Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration

T. Dryja, T. Rejtar, B. Jaffee, 2022, Human molecular genetics.

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.

N. Gradoux, A. Vulpetti, B. Jaffee, 2019, Journal of medicinal chemistry.

Small-molecule factor D inhibitors targeting the alternative complement pathway.

N. Ostermann, C. Durand, A. Vulpetti, 2016, Nature chemical biology.

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models.

T. Dryja, B. Jaffee, Maura A. Crowley, 2018, Investigative ophthalmology & visual science.

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.

Karen Anderson, Anna Vulpetti, Ulrich Hommel, 2017, Journal of medicinal chemistry.

Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1

T. Dryja, B. Jaffee, Jiang Zhu, 2017, Molecular vision.

HtrA1 regulates the subretinal infiltration of microglia cells in response to bacterial lipopolysaccharides (LPS) and aging in mice

B. Jaffee, S. Louie, M. Crowley, 2013 .

Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

T. Dryja, D. Rice, Yubin Qiu, 2021, Investigative ophthalmology & visual science.