Yuanchao Xie

发表

Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC–MS/MS

C. Ke, Jingshan Shen, Jia Liu, 2020, Journal of Pharmaceutical and Biomedical Analysis.

Further discovery of caffeic acid derivatives as novel influenza neuraminidase inhibitors.

Wenfang Xu, Bing Huang, Ke-xiang Yu, 2013, Bioorganic & medicinal chemistry.

Practical and Highly Efficient Synthesis of Remdesivir from GS-441524

Jingshan Shen, H. Aisa, T. Hu, 2022, ACS omega.

Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and β-d-N4-hydroxycytidine

Jingshan Shen, Xiaozhen Guo, Bing Huang, 2021, Virologica Sinica.

Weinreb Amide Approach to the Practical Synthesis of a Key Remdesivir Intermediate.

H. Aisa, Guanghui Tian, Jingshan Shen, 2021, The Journal of organic chemistry.

Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice

Jingshan Shen, Jia Liu, Bo Tan, 2020, Acta pharmacologica Sinica.

A neighboring group participation strategy: facile synthesis of 3,5-di-O-benzoyl-2-C-methyl-d-arabino-γ-lactone

Xiangrui Jiang, Guanghui Tian, Jingshan Shen, 2015 .

Synthesis of CBD and Its Derivatives Bearing Various C4'-side Chains with a Late-Stage Diversification Method.

H. Aisa, Chang-Liang Sun, Jingshan Shen, 2019, The Journal of organic chemistry.

Synthesis and anti-SARS-CoV-2 activity of deuterated GS-441524 analogs

Jingshan Shen, Yumin Zhang, T. Hu, 2022, Tetrahedron Letters.

Caffeic acid derivatives: a new type of influenza neuraminidase inhibitors.

Wenfang Xu, Bing Huang, Fangyuan Shi, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and antiviral activity of 2′‐deoxy‐6′‐substituted carbocyclic nucleosides

Jingshan Shen, T. Hu, Shuang Guo, 2021, Chemical biology & drug design.

Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model

Gengfu Xiao, Lei-ke Zhang, Jingshan Shen, 2022, Signal Transduction and Targeted Therapy.

Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2

H. Aisa, Yuan-Chao Xie, Jingshan Shen, 2021, Bioorganic & Medicinal Chemistry.

Synthesis of cis-4-guanidino-l-proline and 1-carbamimidoyl-l-proline derivatives as influenza neuraminidase inhibitors

Dongqing Xu, W. Xiao, Wenfang Xu, 2015, Medicinal Chemistry Research.

Design, synthesis and biological activity of thiazolidine-4-carboxylic acid derivatives as novel influenza neuraminidase inhibitors.

Fanbo Jing, Minyong Li, Yuan-Chao Xie, 2011, Bioorganic & Medicinal Chemistry.

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

Yan Zhang, Hualiang Jiang, Sheng-Ce Tao, 2020, bioRxiv.

Development of patch and spray formulations for enhancing topical delivery of sinomenine hydrochloride.

Yan Liu, Xinru Li, M. Guo, 2010, Journal of pharmaceutical sciences.

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

Hualiang Jiang, Shuyang Zhang, Gengfu Xiao, 2020, bioRxiv.

One-Pot Synthesis of Molnupiravir from Cytidine

Jingshan Shen, H. Aisa, T. Hu, 2022, Organic Process Research & Development.

Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.

Xiangrui Jiang, Yang He, Qingjie Zhao, 2017, Bioorganic & medicinal chemistry.

Synthesis, structure-activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics.

Xiangrui Jiang, Yang He, Qingjie Zhao, 2016, Bioorganic & medicinal chemistry letters.

The complete synthesis of favipiravir from 2-aminopyrazine

Jingshan Shen, Mingshuo Xu, Shuang Guo, 2019, Chemical Papers.

Synthesis and crystal structure of 6-fluoro-3-hydroxypyrazine-2-carboxamide.

Wenfang Xu, Fangyuan Shi, Tao Zhang, 2014, Drug discoveries & therapeutics.

Viral RNA polymerase: a promising antiviral target for influenza A virus.

Wenfang Xu, Fangyuan Shi, Yuanchao Xie, 2013, Current medicinal chemistry.

Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects

Huahua Duan, Wenhong Zhang, H. Aisa, 2022, Acta Pharmacologica Sinica.

Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

Hualiang Jiang, Yechun Xu, Shuyang Zhang, 2021, Cell Research.

Inhibitors of influenza viruses replication: a patent evaluation (WO2013019828)

W. Xiao, Weiguo Song, Wenfang Xu, 2013, Expert Opinion on Therapeutic Patents.

Patent Evaluation Inhibitors of influenza viruses replication ( WO 2013019828 ) : a patent evaluation

W. Xiao, Weiguo Song, Wenfang Xu, 2013 .

Continuation of structure–activity relationship study of novel benzamide derivatives as potential antipsychotics

Xiangrui Jiang, Yang He, Qingjie Zhao, 2019, Archiv der Pharmazie.

Automated design and optimization of multitarget schizophrenia drug candidates by deep learning.

Hualiang Jiang, M. Zheng, Xutong Li, 2020, European journal of medicinal chemistry.

Automated design and optimization of multitarget schizophrenia drug candidates by deep learning

Chen Cui, Zhaojun Li, Yang He, 2020, bioRxiv.

Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review.

Xiangrui Jiang, Jingshan Shen, Jianfeng Li, 2016, Current drug targets.

Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents.

Qi Guo, Xiangrui Jiang, Jingshan Shen, 2019, Bioorganic & medicinal chemistry.

Facile synthesis of 2-C-methyl-d-arabino-γ-1,4-lactones and mechanism study

Jingshan Shen, T. Hu, Shuang Guo, 2018 .

Discovery of N-substituted oseltamivir derivatives as potent and selective inhibitors of H5N1 influenza neuraminidase.

Xinyong Liu, Dongqing Xu, Yuan-Chao Xie, 2014, Journal of medicinal chemistry.

Industry-Oriented Route Evaluation and Process Optimization for the Preparation of Brexpiprazole

H. Aisa, Jingshan Shen, J. Suo, 2019, Organic Process Research & Development.

NGR-based strategies for targeting delivery of chemotherapeutics to tumor vasculature.

Lei Zhang, Wenfang Xu, Mingming Zou, 2012, Anti-cancer agents in medicinal chemistry.

Study of the Relationship Between Microstructure and Performance for Nox Storage Catalysts

Xingang Li, M. Meng, P. Lin, 2002 .

Progress of HDAC inhibitor panobinostat in the treatment of cancer.

Xiaoyan Li, Z. Yingjie, Jian Zhang, 2014, Current drug targets.