Paola G. S. Murziani

发表

Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells.

D. Kipling, T. Davis, M. Bagley, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells.

D. Kipling, C. Widdowson, T. Davis, 2007, Bioorganic & medicinal chemistry letters.

The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes.

J. Balzarini, S. Liekens, C. Mcguigan, 2011, Biochemical pharmacology.

Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.

J. Balzarini, S. Liekens, C. Mcguigan, 2011, Journal of medicinal chemistry.

Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome

D. Kipling, C. Widdowson, T. Davis, 2010, Pharmaceuticals.

The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.

D. Kipling, T. Davis, Mohammed A. Baashen, 2016, Organic & biomolecular chemistry.

Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells.

D. Kipling, T. Davis, M. Bagley, 2010, Future medicinal chemistry.

The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.

D. Kipling, T. Davis, Mohammed A. Baashen, 2016, Organic & biomolecular chemistry.

The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes.

J. Balzarini, S. Liekens, Magdalena Ślusarczyk, 2011, Biochemical pharmacology.