W. Hamaguchi

发表

Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines.

M. Takeuchi, Y. Matsumoto, M. Ohta, 2009, Bioorganic & medicinal chemistry.

Bifunctional 2-naphthyl propargylic sulfones exhibiting high DNA intercalating and alkylating activity.

L. Zhou, S. Nishimoto, A. Ishii, 1999, Bioorganic & medicinal chemistry letters.

Remarkable tethering effect on DNA cleavage of propargylic sulfone conjugates with intercalating moieties.

L. Zhou, S. Nishimoto, W. Dai, 1998, Bioorganic & medicinal chemistry letters.

Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists.

K. Negoro, M. Takeuchi, S. Yoshida, 2012, Bioorganic & medicinal chemistry.

DNA cleavage potency, cytotoxicity, and mechanism of action of a novel class of enediyne prodrugs.

A. Wu, S. Nishimoto, A. Ishii, 2002, Journal of medicinal chemistry.

Intramolecular Nozaki–Hiyama–Kishi reactions and Ln(III)-catalyzed allylic rearrangement as the key steps towards 10-membered ring enediynes

A. Wu, W. Dai, W. Hamaguchi, 2001 .

Synthesis and DNA Cleavage Study of a 10-Membered Ring Enediyne Formed via Allylic Rearrangement.

W. Dai, Ling Zhou, C. Lau, 1999, The Journal of organic chemistry.

Synthesis and biological evaluation of 3-biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as novel glycine transporter 1 inhibitors.

A. Kohara, S. Tsukamoto, S. Sakamoto, 2011, Journal of medicinal chemistry.

Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors.

T. Mihara, Y. Amano, I. Namatame, 2018, Chemical & pharmaceutical bulletin.

Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors.

Shuichi Sakamoto, Junji Miyata, Takashi Sugane, 2013, Journal of medicinal chemistry.

Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition.

S. Kikuchi, Toshihiro Watanabe, T. Mihara, 2013, Bioorganic & medicinal chemistry.

Addressing phototoxicity observed in a novel series of biaryl derivatives: discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436.

S. Kikuchi, T. Mihara, K. Hattori, 2015, Bioorganic & medicinal chemistry.

Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition.

S. Kikuchi, T. Mihara, K. Hattori, 2015, Bioorganic & medicinal chemistry.

Synthesis and in vivo evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors.

Toshihiro Watanabe, T. Mihara, Kaori Takama, 2014, Chemical and pharmaceutical bulletin.

Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitors.

Y. Amano, Koichi Yonezawa, M. Yamazaki, 2019, Bioorganic & medicinal chemistry.