Mike Bührmann

发表

Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors.

D. Rauh, G. Manfroni, V. Cecchetti, 2019, Biochemical and biophysical research communications.

Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK

M. Ecke, D. Rauh, B. Wiedemann, 2017, PloS one.

Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries

N. London, R. Gabizon, L. Avram, 2022, Journal of medicinal chemistry.

Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK

U. Baumann, U. Knippschild, D. Rauh, 2017, Molecules.

Covalent Lipid Pocket Ligands Targeting p38α MAPK Mutants.

D. Rauh, J. Weisner, J. Hardick, 2017, Angewandte Chemie.

Mechanistic insight into RET kinase inhibitors targeting the DFG-out conformation in RET-rearranged cancer

K. Shokat, Roman K. Thomas, M. Peifer, 2017 .

Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors

K. Shokat, Roman K. Thomas, M. Peifer, 2017, Science Translational Medicine.

Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine.

S. Laufer, G. Zaman, D. Rauh, 2017, Journal of medicinal chemistry.

Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.

Stefan Laufer, Daniel Rauh, Daniel Dauch, 2017, Angewandte Chemie.

Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp3-Enriched Fragment Library.

C. Ehrt, Paul Czodrowski, D. Rauh, 2023, Journal of medicinal chemistry.

Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK

M. Ecke, D. Rauh, B. Wiedemann, 2017, PloS one.