J. Knight

发表

mTORC1 mediated translational elongation limits intestinal tumour initiation and growth

Michael N. Hall, Owen J. Sansom, Nahum Sonenberg, 2014, Nature.

RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3

R. Spriggs, C. Smales, S. Grosso, 2017, Current Biology.

Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.

D. Barrett, C. Smales, A. Willis, 2015, The Biochemical journal.

Active regulator of SIRT1 is required for ribosome biogenesis and function

J. Milner, A. Willis, J. Knight, 2013, Nucleic acids research.

Control of translation in the cold: implications for therapeutic hypothermia.

A. Willis, J. Knight, 2015, Biochemical Society transactions.

TAp73 contributes to the oxidative stress response by regulating protein synthesis

I. Amelio, R. Knight, G. Melino, 2018, Proceedings of the National Academy of Sciences.

Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24Bst Mouse

C. Proud, O. Sansom, C. Smales, 2022, The Journal of Investigative Dermatology.

Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells

R. Zamoyska, A. Willis, Kate M. Dudek, 2017, Proceedings of the National Academy of Sciences.

Regulation of SIRT1 protein in cancer metabolism and ribosome biogenesis

J. Knight, 2011 .

Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells

Victoria Moignard, J. Southgate, D. Coverley, 2010, Nucleic acids research.

A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes

Z. Shah, J. Milner, Simon J. Allison, 2011, Molecular and Cellular Biology.

The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h.

J. Hershey, C. Smales, A. Willis, 2014, The Biochemical journal.

eEF2K activity is required for the phenotypes of the Rpl24Bst mouse.

C. Proud, O. Sansom, C. Smales, 2022, The Journal of investigative dermatology.

Ribosomes and Stress – Linked from Birth to Death

A. Willis, M. Stoneley, T. Sbarrato, 2016 .

Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis

C. Smales, A. Willis, G. Mallucci, 2016, RNA.

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity

J. Milner, Simon J. Allison, S. Allison, 2013, Open Biology.

SIRT1, metabolism and cancer

J. Milner, John R P Knight, J. Knight, 2012, Current opinion in oncology.

Transient association of MCM complex proteins with the nuclear matrix during initiation of mammalian DNA replication

J. Chong, D. Coverley, E. Hesketh, 2015, Cell cycle.

p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.

C. Smales, John R P Knight, A. Willis, 2015, The Biochemical journal.

A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy

S. Puget, J. Grill, J. Kilday, 2015, Genes & development.

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

J. Milner, F. Minutolo, R. Phillips, 2014, Oncogenesis.