B. Ho

发表

The microarray gene profiling analysis of glioblastoma cancer cells reveals genes affected by FAK inhibitor Y15 and combination of Y15 and temozolomide.

Song Liu, J. Conroy, V. Golubovskaya, 2014, Anti-cancer agents in medicinal chemistry.

Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15

Song Liu, J. Conroy, Dan Wang, 2015, Journal of Cancer Research and Clinical Oncology.

A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.

A. Magis, V. Golubovskaya, W. Cance, 2013, Anti-cancer agents in medicinal chemistry.

MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells.

V. Golubovskaya, W. Cance, B. Ho, 2014, Anti-cancer agents in medicinal chemistry.

A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.

V. Golubovskaya, W. Cance, I. Gelman, 2012, Carcinogenesis.

Pharmacologic Blockade of FAK Autophosphorylation Decreases Human Glioblastoma Tumor Growth and Synergizes with Temozolomide

C. Morrison, V. Golubovskaya, W. Cance, 2012, Molecular Cancer Therapeutics.

Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated*

V. Golubovskaya, W. Cance, I. Gelman, 2012, The Journal of Biological Chemistry.

Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth

A. Magis, C. Morrison, V. Golubovskaya, 2013, BMC Cancer.

Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities.

A. Magis, V. Golubovskaya, W. Cance, 2013, Anti-cancer agents in medicinal chemistry.

Gene Expression Profiling Identifies Important Genes Affected by R2 Compound Disrupting FAK and P53 Complex

Song Liu, J. Conroy, Dan Wang, 2014, Cancers.

Focal adhesion kinase regulates expression of thioredoxin-interacting protein (TXNIP) in cancer cells.

V. Golubovskaya, Grace Huang, B. Ho, 2014, Anti-cancer agents in medicinal chemistry.

Abstract C191: Preclinical investigation of the antitumor efficacy in lung cancer of Y15, a novel focal adhesion kinase inhibitor.

V. Golubovskaya, W. Cance, Huanjie Shao, 2011 .