G. Leclerc

发表

Adrenergic receptor subtypes

J. Schwartz, B. Rouot, G. Leclerc, 1981 .

Postjunctional α-adrenoceptors

J. Schwartz, J. Ehrhardt, N. Decker, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

New α, β and y semicarbazone and thiosemicarbazone 1,3-dithiolanes as radioprotectors. Anticonvulsant activity

C. Ribuot, M. Fatôme, J. Laval, 1996 .

Synthesis and vasodilator effects of 3- and 7-sulfonylurea-1,2,4-benzothiadiazin-1,1-dioxides on rat aorta.

G. Faury, J. Verdetti, S. Khelili, 1995, Bioorganic & medicinal chemistry.

Synthesis and beta-adrenergic blocking activity of new aliphatic oxime ethers.

J. Schwartz, G. Leclerc, N. Bieth, 1980, Journal of medicinal chemistry.

Synthesis and biological evaluation of new arylthiophene analogs of DuP 753

P. Dodey, P. Renaut, G. Leclerc, 1995 .

New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties.

P. Faure, S. Collins, E. Nicolle, 2002, Bioorganic & medicinal chemistry letters.

Selective reduction of aromatic / aliphatic nitro groups by sodium sulfide.

G. Leclerc, D. Huber, G. Andermann, 1988 .

Preparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2-butylamino)-4H- and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers.

M. Fillet, B. Pirotte, L. Dupont, 1999, Bioorganic & medicinal chemistry.

Synthesis and pharmacological properties of "soft drug" derivatives related to perhexiline.

J Schwartz, J. Schwartz, G Marciniak, 1988, Journal of medicinal chemistry.

New thiazolo[3,2-a]pyrimidine derivatives, synthesis and structure-activity relationships

G. Leclerc, E. Jeanneau‐Nicolle, M. Benoit‐Guyod, 1992 .

Synthesis and immunomodulating activity of 1-amino-2-thiohydantoin derivatives

M. Blanc, A. Boucherle, G. Leclerc, 1992 .

One-Pot Synthesis of Thiazolidino [3,2-a] Pyrimidine Derivatives

G. Leclerc, E. Jeanneau‐Nicolle, M. Benoit‐Guyod, 1991 .

Short and enantioselective syntheses of (R)- and (S)-2-hydroxymethyl-1,4-benzodioxan

A. Delgado, G. Leclerc, Mariane Lobato, 1988 .

Synthesis and beta-adrenergic blocking activity of new aliphatic and alicyclic oxime ethers.

J. Schwartz, M. Bouzoubaa, N. Decker, 1984, Journal of medicinal chemistry.

Design, syntheses, and activity of new 3-[(sulfonylaryl)-amino]-1,4-benzodiazepin-2-one derivatives as α-thrombin inhibitors

M. Murcko, J. Baldwin, S. D. Lewis, 1998 .

Synthesis of new azepanedione oximes

I. Pitta, G. Leclerc, M. Péra, 2003 .

New calcium antagonists: synthesis, X-ray analysis, and smooth muscle relaxing effect of 3-[O-(benzyl-substituted)-oximino-ethers]-hexahydroazepin-2,3- diones.

P. Devillier, G. Bessard, D. Tranqui, 1999, Bioorganic & medicinal chemistry.

New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.

J. Schwartz, A. Delgado, N. Decker, 1989, Journal of medicinal chemistry.

An efficient and inexpensive resolution of the potent dopaminergic substance 3-(3-Hydroxyphenyl)-N-(1-propyl)-piperidine (±)-3-PPP

J. Neumeyer, H. Law, G. Leclerc, 1991 .

Syntheses and molecular structures of 3-N, N-di-n-propylamino-2-chromanones as new analogues of dopamine.

E. Nicolle, C. Coulombeau, G. Leclerc, 1995, Bioorganic & medicinal chemistry.

New β-adrenoceptor-blocking agents derived from dicyclopropyl ketone oxime: influence of amino substituents on in vivo activity

M. Bouzoubaa, M. Blanc, A. Bouzoubaa, 1994 .

Synthesis and beta-adrenergic blocking activity of a novel class of aromatic oxime ethers.

C. Wermuth, A. Mann, J. Schwartz, 1977, Journal of medicinal chemistry.

New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent beta-adrenergic blocking properties.

M. Bouzoubaa, S. Rakhit, G. Leclerc, 1985, Journal of medicinal chemistry.

Comparison of crystallographic and quantum mechanical analysis with biological data on clonidine and some related analogues.

C. Wermuth, J. Leger, B. Rouot, 1982, Molecular pharmacology.

Clonidine and related analogues. Quantitative correlations.

C. Wermuth, B. Rouot, G. Leclerc, 1976, Journal of medicinal chemistry.

Synthesis of the New Heterocyclic Hydroxy Compounds 4-Hydroxyisoxazolidine, 3-Hydroxymethylisoxazolidine, 3-Hydroxymethylhexahydro-1,2-oxazine, and 4-Hydroxy hexahydro-1,2-oxazepine

N. Amlaiky, G. Leclerc, 1982 .

A convenient synthesis of cis‐4‐(sulfomethyl)‐piperidine‐2‐carboxylic acid: NMR assignment

G. Leclerc, A. E. Hadri, 1993 .

Computer assisted pharmacophore search in a series of non steroidal cardiotonics

J. Schwartz, Gerard Leclerc, G. Marciniak, 1986 .

The use of lithium borohydride for deprotecting acetylated alcohols and phenols in the presence of N-acetylated guanidines

G. Leclerc, D. Huber, G. Andermann, 1986 .

Synthesis of 4-N,N-dialkylaminoethyl-2-indolones as potential dopamine agonists

G. Leclerc, M. Benoit‐Guyod, A. Namil, 1995 .

Synthesis of 4‐N,N‐Dialkylaminoethyl‐2‐indolones as Potential Dopamine Agonists.

G. Leclerc, M. Benoit‐Guyod, A. Namil, 1996 .

A Convenient Synthesis of cis‐4‐(Sulfomethyl)‐piperidine‐2‐carboxylic Acid: NMR Assignment.

G. Leclerc, A. E. Hadri, 1993 .

STUDIES ON SOME para‐SUBSTITUTED CLONIDINE DERIVATIVES THAT EXHIBIT AN α‐ADRENOCEPTOR STIMULANT ACTIVITY

C. Wermuth, J. Schwartz, B. Rouot, 1980, British journal of pharmacology.

X-ray crystal structure and computer modelling of 1,2,3-tris(4-quinolyl)cyclopropane

G. Tamagnan, D. Tranqui, G. Leclerc, 1997 .

New γ-thiazolidine-1,3-dithiolanes as radioprotectors

M. Fatôme, J. Laval, G. Taillandier, 1994 .

New N-ethanethiol pyrroles as radioprotectors

M. Fatôme, J. Laval, G. Taillandier, 1993 .

An efficient synthesis of chlorinated imidazoles through tert-butyldimethylsilyloxy derivatives

P. Dodey, P. Renaut, G. Leclerc, 1994 .

An Efficient Synthesis of Chlorinated Imidazoles Through tert‐ Butyldimethylsilyloxy Derivatives.

P. Dodey, P. Renaut, G. Leclerc, 1995 .

Study of two alkylating derivatives: the p-isothiocyanato- and the p-methylisothiocyanato-clonidine.

J. Schwartz, B. Rouot, N. Decker, 1983, European journal of pharmacology.

Postjunctional a-adrenoceptors 9 1 and ~ 2 subtypes in rat vasculature in vitro and in vivo

J. Schwartz, J. Ehrhardt, N. Decker, 2022 .

Synthesis and irreversible beta-adrenergic blockade with a bromoacetamido derivative of betaxolol.

N. Amlaiky, G. Leclerc, 1985, Journal of pharmaceutical sciences.

Synthesis and Irreversible β-Adrenergic Blockade with a Bromoacetamido Derivative of Betaxolol.

N. Amlaiky, G. Leclerc, 1986 .

Postjunctional alpha-adrenoceptors. Alpha 1 and alpha 2 subtypes in rat vasculature in vitro and in vivo.

J. Schwartz, J. Ehrhardt, N. Decker, 1984, Naunyn-Schmiedeberg's archives of pharmacology.

Synthesis and configuration of 4-alkyl-2-methyl-3,4-diphenyl-1,2-thiazetidine 1,1-dioxide

J. Ehrhardt, G. Leclerc, Evelyne Grander, 2009 .

The 3,4-dimethoxybenzyl group: A protective group for new 2-imino-imidazolidine derivates

J. Ehrhardt, G. Leclerc, D. Huber, 1987 .

Synthesis of 1‐hydroxy‐2H,5H‐dihydroisoxazolo[5,4‐c]quinoline. A novel heterocyclic ring system

B. Ruhland, G. Leclerc, 1989 .

AN IMPROVED SYNTHESIS OF 4-HYDROXY AND 4′-METHOXYBIPHENYL-2-CARBOXYLIC ACIDS

P. Dodey, P. Renaut, G. Leclerc, 1995 .

Second-Generation KATP Channel Openers

Raimund Mannhold, R. Mannhold, Gerard Leclerc, 2005 .

Second-generation K(ATP) channel openers.

R. Mannhold, G. Leclerc, 2005, Mini reviews in medicinal chemistry.

Syntheses, activity and modeling studies of 3- and 4-(sulfo- and sulfonamidoalkyl)pyridine and piperidine-2-carboxylic acid derivatives as analogs of NMDA receptor antagonists.

P. Maldivi, J. Rocher, A. El Hadri, 1995, Bioorganic & medicinal chemistry.

Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors.

D. Tranqui, G. Leclerc, B. Szymonski, 1998, Journal of Medicinal Chemistry.

X-ray analysis and computer assisted molecular modelling in beta-adrenergic blocking agents

J. Leger, M. Bouzoubaa, S. Rakhit, 1986 .

Cardiotonic agents. 2. Synthesis and structure-activity relationships in a new class of 6-, 7-, and 8-pyridyl-2(1H)-quinolone derivatives.

J. Schwartz, N. Decker, G. Leclerc, 1986, Journal of Medicinal Chemistry.

Cardiotonic Agents. Part 2. Synthesis and Structure-Activity Relationships in a New Class of 6-, 7-, and 8-Pyridyl-2(1H)-quinolone Derivatives.

J. Schwartz, N. Decker, G. Leclerc, 1987 .

Synthesis and cardiovascular activity of a new series of cyclohexylaralkylamine derivatives related to perhexiline.

J. Schwartz, N. Decker, G. Leclerc, 1982, Journal of medicinal chemistry.