D. J. Sall

发表

Abstract 2819: Identification and characterization of a novel smoothened antagonist for the treatment of cancer with deregulated hedgehog signaling

P. Hipskind, Hong Gao, K. Credille, 2011 .

Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere.

M. J. Fisher, T. Lindstrom, J. Morin, 2000, Bioorganic & medicinal chemistry letters.

Fused Bicyclic Gly-Asp β-Turn Mimics with Specific Affinity for GPIIb-IIIa

M. J. Fisher, T. Lindstrom, M. Martinelli, 1999 .

Potent benzimidazolone based human β3-adrenergic receptor agonists

M. Heiman, F. Tinsley, A. Kriauciunas, 2006 .

Potent oxindole based human β3 adrenergic receptor agonists

M. Heiman, F. Tinsley, A. Kriauciunas, 2007 .

Characterization of the interaction between human alpha-thrombin and methyl 3-(2-methyl-1-oxopropoxy)[1]benzothieno[3,2-b]furan-2-carboxylate (LY806303) using electrospray mass spectrometry and tandem mass spectrometry.

D. J. Sall, R. Kaiser, 1993, Journal of medicinal chemistry.

D-phenylglycinol-derived non-covalent factor Xa inhibitors: effect of non-peptidic S4 linkage elements on affinity and anticoagulant activity.

T. Craft, V. Klimkowski, N. Y. Chirgadze, 2007, Bioorganic & medicinal chemistry letters.

1,2-Disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors.

R. W. Harper, M. J. Fisher, K. Takeuchi, 2000, Bioorganic & medicinal chemistry letters.

Reduction of Ketones to Alkenes

A. Chamberlin, D. J. Sall, 1991 .

Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 5. Potency, efficacy, and pharmacokinetic properties of modified C-3 side chain derivatives.

R. W. Harper, N. Chirgadze, M. J. Fisher, 2000, Journal of medicinal chemistry.

Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation.

R. W. Harper, N. Chirgadze, S. Briggs, 1997, Journal of medicinal chemistry.

Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists.

J. Wikel, J. Morin, J. Mccowan, 1997, Journal of medicinal chemistry.

Solid phase chemistry approach to the SAR development of a novel class of active site-directed thrombin inhibitors

M. G. Johnson, M. P. Lynch, J. Mccowan, 1999 .

1,2-Disubstituted Indole, Azaindole, and Benzimidazole Derivatives Possessing Amine Moiety: A Novel Series of Thrombin Inhibitors.

R. W. Harper, M. J. Fisher, Minsheng Zhang, 2001 .

Binding requirements of phenolic phenylethylamines in the benzonorbornene skeleton at the active site of phenylethanolamine N-methyltransferase.

G. L. Grunewald, T. Reitz, D. J. Sall, 1986, Journal of medicinal chemistry.

Conformationally defined adrenergic agents. 8. Synthesis of conformationally defined analogs of norfenfluramine. A highly stereospecific synthesis of amines from alcohols in the benzobicyclo[2.2.1]heptene system

M. Pleiss, W. Seibel, G. L. Grunewald, 1983 .

Enantioselective total synthesis of 9S-dihydroerythronolide A seco acid

S. Reich, A. Chamberlin, M. Dezube, 1989 .

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S2) binding site.

J. Wikel, N. Chirgadze, S. Briggs, 1998, Bioorganic & medicinal chemistry letters.

CONFORMATIONALLY DEFINED ADRENERGIC AGENTS. 8. SYNTHESIS OF CONFORMATIONALLY DEFINED ANALOGS OF NORFENFLURAMINE. A HIGHLY STEREOSPECIFIC SYNTHESIS OF AMINES FROM ALCOHOLS IN THE BENZOBICYCLO(2.2.1)HEPTENE SYSTEM

M. Pleiss, W. Seibel, G. L. Grunewald, 1983 .

Chapter 11. Future Antithrombotic Therapy

D. Sall, J. Jakubowski, Gerald F. Smith, 1992 .

Characterization of LY806303 as a potent and selective inhibitor of thrombin

D. R. Berry, T. Craft, D. Gifford-Moore, 1992 .

Platelet glycoprotein IIb–IIIa receptor (GPIIb–IIIa) antagonists derived from amidinoindoles

D. R. Berry, J. Mccowan, J. A. Jakubowski, 1996 .

Conformational preference for the binding of biaryl substrates and inhibitors to the active site of phenylethanolamine N-methyltransferase.

J. Monn, G. L. Grunewald, D. J. Sall, 1988, Journal of medicinal chemistry.

Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors.

J. Mccowan, J. A. Jakubowski, K. Ruterbories, 1997, Journal of medicinal chemistry.

Dibasic benzo[B]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restricted C3-side chain of hydroxybenzo[B]thiophenes.

K. Takeuchi, J. Mccowan, D. Gifford-Moore, 1999, Bioorganic & medicinal chemistry letters.

Modern phenotypic drug discovery is a viable, neoclassic pharma strategy.

D. Sall, Jonathan A. Lee, C. Moxham, 2012, Journal of medicinal chemistry.

Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916

J. F. Schindler, M. Kalos, D. Clawson, 2018, Experimental and Molecular Therapeutics.

The crystal structures of human α‐thrombin complexed with active site‐directed diamino benzo[b] thiophene derivatives: A binding mode for a structurally novel class of inhibitors

M. Zhang, N. Chirgadze, D. Sall, 2008, Protein science : a publication of the Protein Society.

Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines.

J. Monn, G. L. Grunewald, D. J. Sall, 1988, Journal of medicinal chemistry.

Modern phenotypic drug discovery is a viable, neoclassic pharma strategy.

Jonathan A. Lee, C. Moxham, M. Uhlik, 2012, Journal of medicinal chemistry.

Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4" side chain.

J. Wikel, N. Chirgadze, D. Gifford-Moore, 1999, Bioorganic & medicinal chemistry letters.

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy.

R. W. Harper, A. Smith, N. Chirgadze, 1999, Bioorganic & medicinal chemistry letters.

Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site.

G. L. Grunewald, D. J. Sall, 1987, Journal of medicinal chemistry.

The crystal structure of human α‐thrombin complexed with LY178550, a nonpeptidyl, active site‐directed inhibitor

N. Chirgadze, D. Sall, S. Briggs, 1997, Protein science : a publication of the Protein Society.