Mai Yagi

Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives.

R. Tanimura, Yuji Sugawara, K. Kawai, 2017, Bioorganic & medicinal chemistry letters.

Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases.

M. Yamada, Y. Kato, H. Kigoshi, 2014, Bioorganic & medicinal chemistry letters.

Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension.

M. Yamada, Y. Kato, Takumi Aoki, 2013, Bioorganic & medicinal chemistry letters.

Discovery of potent α1L-adrenoceptor agonists: Design and synthesis of bicyclic derivatives.

Tsubasa Okano, Y. Yoshizawa, Ryoji Hayashi, 2015, Bioorganic & Medicinal Chemistry Letters.

HIS-388, a Novel Orally Active and Long-Acting 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, Ameliorates Insulin Sensitivity and Glucose Intolerance in Diet-Induced Obesity and Nongenetic Type 2 Diabetic Murine Models

S. Okazaki, Takehiro Takahashi, K. Kawai, 2014, The Journal of Pharmacology and Experimental Therapeutics.

HIS-388, a Novel Orally Active and Long-Acting 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, Ameliorates Insulin Sensitivity and Glucose Intolerance in Diet-Induced Obesity and Nongenetic Type 2 Diabetic Murine Models

S. Okazaki, M. Kainoh, Takehiro Takahashi, 2014, The Journal of Pharmacology and Experimental Therapeutics.