J. Newitt

发表

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.

L. Mueller, S. Sheriff, David K. Williams, 2006, Bioorganic & medicinal chemistry letters.

Development and Fit-for-Purpose Validation of a Soluble Human Programmed Death-1 Protein Assay

Robert J. Neely, S. Piccoli, V. Lafont, 2015, The AAPS Journal.

Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.

J. Barrish, D. Xie, N. Murugesan, 2020, ACS medicinal chemistry letters.

Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor.

J. Sack, Chunhong Yan, S. E. Kiefer, 2015, Acta crystallographica. Section F, Structural biology communications.

Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.

A. Doweyko, James Lin, J. Wityak, 2010, Journal of medicinal chemistry.

The Crystal Structure of Abl Kinase with BMS-354825, a Dual SRC/ABL Kinase Inhibitor.

J. Tokarski, K. Kish, H. Klei, 2004 .

Inhibition of the conversion of 3T3 fibroblast clones to adipocytes by dehydroepiandrosterone and related anticarcinogenic steroids.

G. Gordon, L. Shantz, P. Talalay, 1986, Cancer research.

The Discovery of BMS-737 as a Potent, CYP17 Lyase-Selective Inhibitor for the Treatment of Castration-Resistant Prostate Cancer.

J. Tokarski, A. Fura, L. Jayaraman, 2022, Bioorganic & medicinal chemistry letters.

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer.

A. Doweyko, G. Trainor, A. Fura, 2016, ACS medicinal chemistry letters.

A Mutation in the Escherichia coli secY Gene That Produces Distinct Effects on Inner Membrane Protein Insertion and Protein Export*

H. Bernstein, J. Newitt, 1998, The Journal of Biological Chemistry.

Inhibition of the conversion of 3T3 fibroblast clones to adipocytes by dehydroepiandrosterone and related anticarcinogenic steroids.

G. Gordon, L. Shantz, P. Talalay, 1986, Cancer research.

Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.

J. Macor, K. Kish, E. Baldwin, 2015, Bioorganic & medicinal chemistry letters.

Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.

John Dodd, John S Tokarski, Arthur M Doweyko, 2008, Journal of medicinal chemistry.

Structural basis for the high-affinity binding of pyrrolotriazine inhibitors of p38 MAP kinase.

K. Kish, D. Xie, J. Sack, 2008, Acta Crystallographica Section D: Biological Crystallography.

Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.

Wayne Vaccaro, Steven Sheriff, Neil Burford, 2006, Bioorganic & medicinal chemistry letters.

The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode.

A. Doweyko, Sidney Pitt, M. Witmer, 2013, Bioorganic & medicinal chemistry letters.

Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects.

Wayne Vaccaro, Luciano Mueller, K. Constantine, 2008, Journal of medicinal chemistry.

The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants.

M. Wittekind, J. Tokarski, K. Kish, 2006, Cancer research.

The E. coli Signal Recognition Particle Is Required for the Insertion of a Subset of Inner Membrane Proteins

J. A. Newitt, H. Bernstein, N. Ulbrandt, 1997, Cell.

Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

Micah T. Nelp, J. Groves, J. Hunt, 2018, Proceedings of the National Academy of Sciences.

Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors.

A. Doweyko, Sidney Pitt, G. Schieven, 2010, Bioorganic & medicinal chemistry letters.

The Structure of Multiple Polypeptide Domains Determines the Signal Recognition Particle Targeting Requirement ofEscherichia coli Inner Membrane Proteins

J. A. Newitt, H. Bernstein, N. Ulbrandt, 1999, Journal of bacteriology.

5-amino-pyrazoles as potent and selective p38α inhibitors.

A. Doweyko, R. Moquin, K. McIntyre, 2010, Bioorganic & medicinal chemistry letters.

Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.

A. Doweyko, K. McIntyre, D. Shuster, 2011, Bioorganic & medicinal chemistry letters.

Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening.

L. Mueller, D. Cheney, W. Metzler, 2015, Journal of medicinal chemistry.

Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity.

D. Xie, S. Sheriff, Chunhong Yan, 2016, Acta crystallographica. Section D, Structural biology.

A highly conserved nucleotide in the Alu domain of SRP RNA mediates translation arrest through high affinity binding to SRP9/14.

Kelvin Hsu, R. Maraia, H. Bernstein, 1997, Nucleic acids research.

Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).

D. Xie, S. Sheriff, D. Lipovšek, 2020, Acta crystallographica. Section F, Structural biology communications.

Assessing compound binding to the Eg5 motor domain using a thermal shift assay.

M. Doyle, V. Goldfarb, W. Metzler, 2009, Analytical biochemistry.

Synthesis and Biological Evaluation of Biaryl Alkyl Ethers as Inhibitors of IDO1.

Xin Li, J. Hunt, L. Jayaraman, 2023, Bioorganic & medicinal chemistry letters.

The N-domain of the signal recognition particle 54-kDa subunit promotes efficient signal sequence binding.

J. A. Newitt, H. Bernstein, J. Newitt, 1997, European journal of biochemistry.

The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.

A. Doweyko, K. McIntyre, D. Shuster, 2008, Bioorganic & medicinal chemistry letters.

Development and Fit-for-Purpose Validation of a Soluble Human Programmed Death-1 Protein Assay

Robert J. Neely, S. Piccoli, V. Lafont, 2015, The AAPS Journal.

Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor.

J. Sack, Chunhong Yan, S. E. Kiefer, 2015, Acta crystallographica. Section F, Structural biology communications.

Native Mass Spectrometry and Gas-Phase Fragmentation Provide Rapid and In-Depth Topological Characterization of a PROTAC Ternary Complex

M. Gross, J. A. Newitt, A. Balog, 2021, Cell chemical biology.

Orthosteric STING inhibition elucidates molecular correction of SAVI STING

A. Dyckman, J. Newitt, Luciano Mueller, 2024, bioRxiv.