Aixin Yu

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Thymic Development Maturation of Regulatory T Cells during IL-2R Signaling Is Essential for Functional

T. Malek, Michael J. Dee, Aixin Yu, 2013 .

The Basis of Distinctive IL-2– and IL-15–Dependent Signaling: Weak CD122-Dependent Signaling Favors CD8+ T Central-Memory Cell Survival but Not T Effector-Memory Cell Development

T. Malek, Michael J. Dee, I. Castro, 2011, The Journal of Immunology.

CD 122-Dependent Signaling Favors CD 8 Dependent Signaling : Weak − and IL-15 − The Basis of Distinctive IL-2

T. Malek, I. Castro, Aixin Yu, 2011 .

Differentiated T Regulatory Cells Terminally + Development of Klrg1 IL-2 Receptor Signaling Is Essential for the

T. Malek, E. Podack, Guoyan Cheng, 2012 .

Broad Programming by IL-2 Receptor Signaling for Extended Growth to Multiple Cytokines and Functional Maturation of Antigen-Activated T Cells1

T. Malek, E. Codias, P. Scibelli, 2001, The Journal of Immunology.

Antigen-Activated T Cells Cytokines and Functional Maturation of Signaling for Extended Growth to Multiple Broad Programming by IL-2 Receptor Lichtenheld

T. Malek, E. Codias, P. Scibelli, 2001 .

Efficient Induction of Primary and Secondary T Cell-Dependent Immune Responses In Vivo in the Absence of Functional IL-2 and IL-15 Receptors1

T. Malek, C. Bergmann, R. Levy, 2003, The Journal of Immunology.

Receptorsin the Absence of Functional IL-2 and IL-15 Vivo T Cell-Dependent Immune Responses In Efficient Induction of Primary and Secondary

T. Malek, C. Bergmann, R. Levy, 2002 .

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.

T. Malek, V. Vincek, P. Scibelli, 2002, Immunity.

IL-2R Signaling Is Essential for Functional Maturation of Regulatory T Cells during Thymic Development

T. Malek, Michael J. Dee, Guoyan Cheng, 2013, The Journal of Immunology.

T‐cell tolerance and the multi‐functional role of IL‐2R signaling in T‐regulatory cells

T. Malek, Guoyan Cheng, Aixin Yu, 2011, Immunological reviews.

IL-2 Receptor Signaling Is Essential for the Development of Klrg1+ Terminally Differentiated T Regulatory Cells

T. Malek, E. Podack, Matthew S Tsai, 2012, The Journal of Immunology.

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

Paul D. Morton, T. Malek, C. Moraes, 2016, Cell Death and Differentiation.

Efficient Internalization of IL-2 Depends on the Distal Portion of the Cytoplasmic Tail of the IL-2R Common γ-Chain and a Lymphoid Cell Environment1

T. Malek, A. Yu, C. Y. Choi, 2000, The Journal of Immunology.

Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells1

T. Malek, A. Bayer, A. Yu, 2007, The Journal of Immunology.

Developmental Progression and Interrelationship of Central and Effector Regulatory T Cell Subsets

T. Malek, Michael J. Dee, Jing Yang, 2016, The Journal of Immunology.

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

D. Klatzmann, A. Hartemann, T. Malek, 2015, Journal of autoimmunity.

A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.

Linjiang Zhu, T. Malek, N. Altman, 2009, Immunity.

Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period

T. Malek, D. Adeegbe, A. Bayer, 2005, The Journal of experimental medicine.

Normal Lymphoid Homeostasis and Lack of Lethal Autoimmunity in Mice Containing Mature T Cells with Severely Impaired IL-2 Receptors1

T. Malek, A. Yu, B. O. Porter, 2000, The Journal of Immunology.

IL-2 Family of Cytokines in T Regulatory Cell Development and Homeostasis

Linjiang Zhu, T. Malek, D. Adeegbe, 2008, Journal of Clinical Immunology.

Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes

D. Klatzmann, T. Malek, A. Pugliese, 2015, Diabetes.

Distinct Activation Signals Determine whether IL-21 Induces B Cell Costimulation, Growth Arrest, or Bim-Dependent Apoptosis1

T. Malek, R. Carrio, Haoli Jin, 2004, The Journal of Immunology.

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T 1 D patients Running head : dose-dependent low dose IL-2 immunoregulation

D. Klatzmann, A. Hartemann, T. Malek, 2017 .

Dynamic transcriptional activity and chromatin remodeling of regulatory T cells after varied duration of interleukin-2 receptor signaling

X. Chen, T. Malek, Zhen Gao, 2022, Nature Immunology.

Dynamic transcriptional activity and chromatin remodeling of regulatory T cells after varied duration of interleukin-2 receptor signaling

T. Malek, Zhen Gao, Yuguang Ban, 2022, Nature immunology.

Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms

M. Struthers, Liping Yu, T. Malek, 2020, Diabetes.

IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells

A. Yamniuk, M. Struthers, T. Malek, 2018, The Journal of Immunology.

Growth Arrest , or Bim-Dependent Apoptosis whether IL-21 Induces B Cell Costimulation , Distinct Activation Signals Determine

T. Malek, R. Carrio, Haoli Jin, 2004 .

The Proteasome Regulates Receptor-mediated Endocytosis of Interleukin-2*

T. Malek, A. Yu, Aixin Yu, 2001, The Journal of Biological Chemistry.

CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells

T. Malek, Ying Ding, G. Tsokos, 2019, The Journal of Immunology.

Quantitative assessment concerning the contribution of IL-2Rbeta for superantigen-mediated T cell responses in vivo.

T. Malek, D. Adeegbe, C. Rolle, 2006, International immunology.

Selective Availability of IL-2 Is a Major Determinant Controlling the Production of CD4+CD25+Foxp3+ T Regulatory Cells1

T. Malek, A. Yu, Aixin Yu, 2006, The Journal of Immunology.

The Lower Limit of Regulatory CD4+ Foxp3+ TCRβ Repertoire Diversity Required To Control Autoimmunity

T. Malek, D. Adeegbe, C. Dwyer, 2017, The Journal of Immunology.

during the neonatal period

T. Malek, D. Adeegbe, A. Bayer, 2005 .

Differentiated T Regulatory Cells Terminally + Development of Klrg 1 IL-2 Receptor Signaling Is Essential for the Podack

T. Malek, E. Podack, Matthew S Tsai, 2012 .

This information is current as Receptors Mature T Cells with Severely Impaired IL-2 Lethal Autoimmunity in Mice Containing Normal Lymphoid Homeostasis and Lack of Scibelli and Aixin

T. Malek, B. O. Porter, E. Codias, 2000 .

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

D. Klatzmann, A. Hartemann, T. Malek, 2015, Journal of autoimmunity.

Persistent IL-2R signaling by IL-2/CD25 fusion protein controls diabetes in NOD mice by multiple mechanisms

M. Struthers, Liping Yu, T. Malek, 2020 .

IL-2 Receptor Signaling Is Essential for the Development of Klrg1+ Terminally Differentiated T Regulatory Cells

T. Malek, E. Podack, Matthew S Tsai, 2012, The Journal of Immunology.

Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period

T. Malek, D. Adeegbe, A. Bayer, 2005, The Journal of experimental medicine.

This information is current as Regulatory Cells T + Foxp 3 + CD 25 + Peripheral CD 4 Function of the IL-2 R for Thymic and

T. Malek, A. Bayer, Aixin Yu, 2007 .

This information is current as Control Autoimmunity Repertoire Diversity Required To β TCR + Foxp 3 + The Lower Limit of Regulatory CD 4

T. Malek, D. Adeegbe, Michael J. Dee, 2017 .