Hannes Heinel

Binding of Bexarotene to the Amyloid Precursor Protein Transmembrane Domain in Liposomes Alters its α -Helical Conformation but Inhibits γ -Secretase Non-Selectively

C. Sanders, H. Scheidt, D. Huster, 2018 .

Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.

D. Huster, B. Luy, D. Langosch, 2019, Biophysical journal.

Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage

D. Huster, B. Luy, D. Langosch, 2018, bioRxiv.

Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage

D. Huster, B. Luy, D. Langosch, 2018, bioRxiv.

Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes.

C. Sanders, H. Scheidt, D. Huster, 2018, ACS chemical neuroscience.

Stabilization / destabilization of the APP transmembrane domain by mutations in the di-glycine hinge alter helical structure and dynamics, and impair cleavage by !- secretase

D. Huster, B. Luy, Alexander Vogel, 2018 .