C. Burgey

发表

Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain.

D. Henze, S. Grauer, A. Palani, 2021, Journal of medicinal chemistry.

Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine.

H. Selnick, M. Fraley, D. Gauvreau, 2015, Bioorganic & medicinal chemistry letters.

Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine.

A. W. Shaw, Y. S. Tang, S. Kane, 2009, European journal of pharmacology.

Pharmacological Characterization of MK-0974 [N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of

A. W. Shaw, J. Vacca, Victor K. Johnston, 2008, Journal of Pharmacology and Experimental Therapeutics.

Active CGRP Receptor Antagonist for the Treatment of Migraine

A. W. Shaw, J. Vacca, S. Graham, 2007 .

Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor

E. Hostetler, C. Regan, M. Fraley, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

D. Henze, C. Regan, Yuxing Li, 2022, Channels.

Caprolactams as potent CGRP receptor antagonists for the treatment of migraine.

A. W. Shaw, S. Graham, R. Z. Rutledge, 2007, Bioorganic & medicinal chemistry letters.

Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine.

J. Vacca, S. Graham, R. Z. Rutledge, 2006, Bioorganic & medicinal chemistry letters.

Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).

A. W. Shaw, J. Vacca, Victor K. Johnston, 2007, Journal of medicinal chemistry.

C2-SYMMETRIC COPPER(II) COMPLEXES AS CHIRAL LEWIS ACIDS. ENANTIOSELECTIVE CATALYSIS OF THE GLYOXYLATE-ENE REACTION

Nick A. Paras, Davidr . Evans, N. Paras, 1998 .

Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization.

Lawrence C Kuo, Berta Strulovici, Daniel R McMasters, 2005, Bioorganic & medicinal chemistry letters.

P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold.

Youwei Yan, L. Kuo, J. Vacca, 2005, Bioorganic & medicinal chemistry letters.

Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides.

Youwei Yan, L. Kuo, J. Vacca, 2003, Bioorganic & medicinal chemistry letters.

Carbohydrates to carbocycles: synthesis of the densely functionalized carbocyclic core of tetrodotoxin by radical cyclization of an anhydro sugar precursor

G. Vite, R. Alonso, B. Fraser-Reid, 1993 .

Copper-facilitated Suzuki reactions: application to 2-heterocyclic boronates.

S. Stauffer, S. Dreher, H. Kurihara, 2009, Organic letters.

Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.

Daniel R McMasters, James C Barrow, W. M. Sanders, 2003, Journal of medicinal chemistry.

C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Scope and Mechanism of Catalytic Enantioselective Aldol Additions of Enolsilanes to (Benzyloxy)acetaldehyde

Davidr . Evans, M. Kozlowski, R. Staples, 1999 .

C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Catalytic Enantioselective Carbonyl−Ene Reactions with Glyoxylate and Pyruvate Esters

Davidr . Evans, Steven W. Tregay, T. Vojkovský, 2000 .

Reversal in enantioselectivity of tert-butyl versus phenyl-substituted bis(oxazoline) copper(II) catalyzed hetero Diels-Alder and ene reactions. Crystallographic and mechanistic studies

Davidr . Evans, K. Campos, Jeffrey S. Johnson, 1999 .

Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.

A. W. Shaw, J. Vacca, H. Selnick, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of the (3R,6S)-3-amino-6-(2,3-difluorophenyl)azepan-2-one of telcagepant (MK-0974), a calcitonin gene-related peptide receptor antagonist for the treatment of migraine headache.

A. W. Shaw, J. Vacca, S. Graham, 2008, Organic letters.

Calcitonin gene-related peptide receptor antagonists for the treatment of migraine.

T. Williams, C. Salvatore, C. Burgey, 2009, Progress in medicinal chemistry.

C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Scope and Mechanism of the Catalytic Enantioselective Aldol Additions of Enolsilanes to Pyruvate Esters

Davidr . Evans, M. Kozlowski, Steven W. Tregay, 1999 .

C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Scope and Mechanism of Catalytic Enantioselective Aldol Additions of Enolsilanes to (Benzyloxy)acetaldehyde.

Davidr . Evans, M. Kozlowski, R. Staples, 1999 .

Expanding the scope of the Cu assisted Suzuki–Miyaura reaction

Christopher K. Prier, B. Crowley, C. Burgey, 2011 .

C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Catalytic Enantioselective Carbonyl—Ene Reactions with Glyoxylate and Pyruvate Esters.

Davidr . Evans, N. Paras, Steven W. Tregay, 2000 .

Carbohydrates to densely functionalized carbocycles: 'armed and disarmed' effects in an approach to tetrodotoxin

B. Fraser-Reid, R. Vollerthun, C. Burgey, 1998 .

Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.

K. K. Nanda, D. Henze, Suzie Yeh, 2011, Bioorganic & medicinal chemistry letters.

In vitro metabolism of a thrombin inhibitor and quantitation of metabolically generated cyanide.

C. Gibson, B. Wong, C. Lin, 2005, Journal of pharmaceutical and biomedical analysis.

A novel and efficient synthesis of 2,5-substituted 1,2,4-triazol-3-ones

C. Burgey, James Z. Deng, 2005 .

Translational Pharmacokinetic–Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose

D. Henze, C. Gibson, R. Kraus, 2021, Frontiers in Pharmacology.

Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate

D. Henze, C. Gibson, Yuxing Li, 2020, Pharmaceutical Research.

Mechanism of inhibition of human leucocyte elastase by beta-lactams. 2. Stability, reactivation kinetics, and products of beta-lactam-derived E-I complexes.

D. Underwood, R. Chabin, A. Maycock, 1995, Biochemistry.

Mechanism of inhibition of human leucocyte elastase by beta-lactams. 3. Use of electrospray ionization mass spectrometry and two-dimensional NMR techniques to identify beta-lactam-derived E-I complexes.

D. Underwood, M. Maccoss, R. Chabin, 1995, Biochemistry.

Lead Optimization of Cathepsin K Inhibitors for the Treatment of Osteoarthritis.

K. K. Nanda, B. Ma, G. Wesolowski, 2022, Bioorganic & medicinal chemistry letters.

Nav1.7 target modulation and efficacy can be measured in nonhuman primate assays

D. Henze, Yuxing Li, R. Kraus, 2021, Science Translational Medicine.

Decahydroquinoline amides as highly selective CB2 agonists: role of selectivity on in vivo efficacy in a rodent model of analgesia.

D. Henze, Suzie Yeh, G. Hartman, 2011, Bioorganic & medicinal chemistry letters.

Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.

T. Baillie, P. Pearson, B. Wong, 2003, Chemical research in toxicology.

Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.

J. Vacca, T. Williams, Sean Yu, 2009, Bioorganic & medicinal chemistry letters.

Armed/disarmed effects in the solvolysis of caged 1,6-anhydro pyranoses

B. Fraser-Reid, R. Vollerthun, C. Burgey, 1994 .