Edward A Arnold

发表

HSV-1 exploits host heterochromatin for egress

S. Ramachandran, Hannah C. Lewis, D. C. Avgousti, 2022, bioRxiv.

Sialylated Receptor Setting Influences Mycoplasma pneumoniae Attachment and Gliding Motility

J. Locklin, D. C. Krause, Caitlin R. Williams, 2018, Molecular microbiology.

Molecular Modeling and Biochemical Characterization Reveal the Mechanism of Hepatitis B Virus Polymerase Resistance to Lamivudine (3TC) and Emtricitabine (FTC)

S. Sarafianos, C. Gibbs, Huiling Yang, 2001, Journal of Virology.

Human Rhinovirus Type 14:Human Immunodeficiency Virus Type 1 (HIV-1) V3 Loop Chimeras from a Combinatorial Library Induce Potent Neutralizing Antibody Responses against HIV-1

P. Lewi, A. A. Chen, G. F. Arnold, 1998, Journal of Virology.

Selective Excision of AZTMP by Drug-Resistant Human Immunodeficiency Virus Reverse Transcriptase

S. Sarafianos, P. Boyer, S. Hughes, 2001, Journal of Virology.

Molecular dynamics of HIV‐1 reverse transcriptase indicates increased flexibility upon DNA binding

J. Madura, Jianping Ding, J. Lukin, 2001, Proteins.

Identification of a pharmacophore for nucleoside analog inhibitors directed at HIV‐1 reverse transcriptase

D. Kristol, M. Modak, P. Yadav, 1994, Journal of molecular recognition : JMR.

Mutations in the 5 (cid:2) End of the Human Immunodeﬁciency Virus Type 1 Polypurine Tract Affect RNase H Cleavage Speciﬁcity and Virus Titer

S. Sarafianos, S. Hughes, J. G. Julias, 2003 .

RNase H Cleavage of the 5 (cid:2) End of the Human Immunodeﬁciency Virus Type 1 Genome

S. Sarafianos, S. Hughes, Honghai Gao, 2001 .

Adenovirus protein VII binds the A-box of HMGB1 to repress interferon responses

Monica S. Guo, Mia R Brinkley, Edward A Arnold, 2023, bioRxiv.

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

A. D. Clark, Jianping Ding, Roger L. Williams, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase.

A. D. Clark, Jianping Ding, R. Raag, 1995, Biochemistry.

HSV-1 exploits host heterochromatin for nuclear egress

S. Ramachandran, Hannah C. Lewis, J. Bosse, 2023, The Journal of cell biology.

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.

A. D. Clark, Jianping Ding, S. Sarafianos, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

E. Arnold, T. Shirasaka, M. Alcaide, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance.

Jianping Ding, R. Pauwels, P. Boyer, 1994, Journal of molecular biology.

The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.

A. D. Clark, Jianping Ding, P. Boyer, 2001, Journal of molecular biology.

The atomic structure of Mengo virus at 3.0 A resolution.

G. Vriend, G. Vriend, M. Rossmann, 1987, Science.

Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase.

S. Sarafianos, P. Boyer, S. Hughes, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance.

A. D. Clark, Jianping Ding, S. Hughes, 1998, Journal of molecular biology.

Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.

A. D. Clark, Jianping Ding, R. Pauwels, 1996, Journal of molecular biology.

Protein-nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer.

Jianping Ding, S. Hughes, E. Arnold, 1997, Biopolymers.

Mutational analysis of the fingers and palm subdomains of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase.

P. Boyer, P. Clark, S. Hughes, 1994, Journal of molecular biology.

Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.

P. Boyer, S. Hughes, E. Arnold, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Crystal structure of Myxococcus xanthus nucleoside diphosphate kinase and its interaction with a nucleotide substrate at 2.0 A resolution.

S. Inouye, M. Inouye, Roger L. Williams, 1994, Journal of molecular biology.

Effects of mutations in the polymerase domain on the polymerase, RNase H and strand transfer activities of human immunodeficiency virus type 1 reverse transcriptase.

P. Boyer, S. Hughes, E. Arnold, 1998, Journal of molecular biology.

HIV reverse transcriptase structure-function relationships.

E. Arnold, A. Jacobo-Molina, E Arnold, 1991, Biochemistry.

Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.

R. Pauwels, E. Arnold, F. Daeyaert, 2001, Bioorganic & medicinal chemistry letters.

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.

R. Pauwels, E. Arnold, F. Daeyaert, 2001, Bioorganic & medicinal chemistry letters.

Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms.

A. D. Clark, Jianping Ding, E. Arnold, 1996, Structure.

Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5-A resolution.

A. D. Clark, P. Clark, S. Hughes, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Structures of DNA and RNA polymerases and their interactions with nucleic acid substrates.

S. Hughes, E. Arnold, J. Ding, 1995, Current opinion in structural biology.

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

E. Arnold, R. Kirsch, Y. Hsiou, 1996, Proceedings of the National Academy of Sciences of the United States of America.

The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

S. Sarafianos, P. Boyer, S. Hughes, 2000, Journal of molecular biology.

Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site.

S. Sarafianos, P. Boyer, S. Hughes, 1999, Chemistry & biology.